Search Results - "Buongervino, Samantha N"

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors by Foster, Jessica B, Griffin, Crystal, Rokita, Jo Lynne, Stern, Allison, Brimley, Cameron, Rathi, Komal, Lane, Maria V, Buongervino, Samantha N, Smith, Tiffany, Madsen, Peter J, Martinez, Daniel, Delaidelli, Alberto, Sorensen, Poul H, Wechsler-Reya, Robert J, Karikó, Katalin, Storm, Phillip B, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R

“…BackgroundPediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Glypican 2 (GPC2) is a cell…”
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GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies by Pascual-Pasto, Guillem, McIntyre, Brendan, Shraim, Rawan, Buongervino, Samantha N, Erbe, Amy K, Zhelev, Doncho V, Sadirova, Shakhnozakhon, Giudice, Anna M, Martinez, Daniel, Garcia-Gerique, Laura, Dimitrov, Dimiter S, Sondel, Paul M, Bosse, Kristopher R

“…BackgroundAntibody–drug conjugates (ADCs) that deliver cytotoxic drugs to tumor cells have emerged as an effective and safe anticancer therapy. ADCs may induce…”
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Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma by Bosse, Kristopher R, Giudice, Anna Maria, Lane, Maria V, McIntyre, Brendan, Schürch, Patrick M, Pascual-Pasto, Guillem, Buongervino, Samantha N, Suresh, Sriyaa, Fitzsimmons, Alana, Hyman, Adam, Gemino-Borromeo, Maria, Saggio, Jennifer, Berko, Esther R, Daniels, Alexander A, Stundon, Jennifer, Friedrichsen, Megan, Liu, Xin, Margolis, Matthew L, Li, Marilyn M, Tierno, Marni Brisson, Oxnard, Geoffrey R, Maris, John M, Mossé, Yael P

“…Neuroblastoma evolution, heterogeneity, and resistance remain inadequately defined, suggesting a role for circulating tumor DNA (ctDNA) sequencing. To define…”
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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope by Raman, Swetha, Buongervino, Samantha N, Lane, Maria V, Zhelev, Doncho V, Zhu, Zhongyu, Cui, Hong, Martinez, Benjamin, Martinez, Daniel, Wang, Yanping, Upton, Kristen, Patel, Khushbu, Rathi, Komal S, Navia, Carmen T, Harmon, Daniel B, Li, Yimei, Pawel, Bruce, Dimitrov, Dimiter S, Maris, John M, Julien, Jean-Philippe, Bosse, Kristopher R

“…Glypican 2 (GPC2) is a MYCN-regulated, differentially expressed cell-surface oncoprotein and target for immune-based therapies in neuroblastoma. Here, we build…”
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