Search Results - "Buon, Leutz"

Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma by Talluri, Srikanth, Samur, Mehmet K., Buon, Leutz, Kumar, Subodh, Potluri, Lakshmi B., Shi, Jialan, Prabhala, Rao H., Shammas, Masood A., Munshi, Nikhil C.

“…Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in…”
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RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid Tumors by Liao, Chengcheng, Talluri, Srikanth, Zhao, Jiangning, Mu, Shidai, Kumar, Subodh, Shi, Jialan, Buon, Leutz, Munshi, Nikhil C, Shammas, Masood A

“…In normal cells, homologous recombination (HR) is tightly regulated and plays an important role in the maintenance of genomic integrity and stability through…”
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Identification and validation of ecto-5' nucleotidase as an immunotherapeutic target in multiple myeloma by Ray, Arghya, Song, Yan, Du, Ting, Buon, Leutz, Tai, Yu-Tzu, Chauhan, Dharminder, Anderson, Kenneth C.

“…Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces…”
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Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma by Kumar, Subodh, Buon, Leutz, Talluri, Srikanth, Roncador, Marco, Liao, Chengcheng, Zhao, Jiangning, Shi, Jialan, Chakraborty, Chandraditya, Gonzalez, Gabriel, Tai, Yu-Tzu, Prabhala, Rao, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.

“…Esophageal adenocarcinoma (EAC) is associated with a marked genomic instability, which underlies disease progression and development of resistance to…”
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Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib by OOI, Melissa G, HAYDEN, Patrick J, BUON, Leutz, CLYNES, Martin, O'GORMAN, Peter, RICHARDSON, Paul G, MITSIADES, Constantine S, ANDERSON, Kenneth C, MITSIADES, Nicholas, KOTOULA, Vassiliki, MCMILLIN, Douglas W, CHARALAMBOUS, Elpida, DASKALAKI, Emily, RAJE, Noopur S, MUNSHI, Nikhil C, CHAUHAN, Dharminder, HIDESHIMA, Teru

“…Purpose: p53 is inactivated in many human malignancies through missense mutations or overexpression of the human homologue of Mdm2 (Hdm2), an E3 ubiquitin…”
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Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma by Alagpulinsa, David A., Kumar, Subodh, Talluri, Srikanth, Nanjappa, Purushothama, Buon, Leutz, Chakraborty, Chandraditya, Samur, Mehmet K., Szalat, Raphael, Shammas, Masood A., Munshi, Nikhil C.

“…•UBE2T is frequently amplified and/or overexpressed and is required for homologous recombination activity in multiple myeloma cells.•UBE2T is a potential…”
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Biology and Prognostic Implications of Bone Marrow Plasmacytoid Dendritic Cells in Multiple Myeloma Pathogenesis By Single-Cell RNA Sequencing by Ray, Arghya, Buon, Leutz, DU, Ting, Wan, Xueping, Chauhan, Dharminder, Anderson, Kenneth C.

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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia by Bhatt, Shruti, Pioso, Marissa S., Olesinski, Elyse Anne, Yilma, Binyam, Ryan, Jeremy A., Mashaka, Thelma, Leutz, Buon, Adamia, Sophia, Zhu, Haoling, Kuang, Yanan, Mogili, Abhishek, Louissaint, Abner, Bohl, Stephan R., Kim, Annette S., Mehta, Anita K., Sanghavi, Sneha, Wang, Youzhen, Morris, Erick, Halilovic, Ensar, Paweletz, Cloud P., Weinstock, David M., Garcia, Jacqueline S., Letai, Anthony

“…Acquired resistance to BH3 mimetic antagonists of BCL-2 and MCL-1 is an important clinical problem. Using acute myelogenous leukemia (AML) patient-derived…”
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Flap Structure-Specific Endonuclease 1 Coordinates with a Helicase (ASCC3) to Drive Genomic Instability, Proliferation and Poor Clinical Outcome in Myeloma by Liao, Chengcheng, Talluri, Srikanth, Mu, Shidai, Kumar, Subodh, Potluri, Lakshmi B., Shi, Jialan, Buon, Leutz, Shammas, Masood A., Munshi, Nikhil C

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P-281 Novel Whole-Genome DNA-Damage Functional Screen Identifies Drivers of DNA Damage in Multiple Myeloma by Talluri, Srikanth, Buon, Leutz, Zhao, Jiangning, Meglino, Daniel, Chakraborty, Chandraditya, Liao, Chengcheng, Samur, Mehmet, Shammas, Masood, Munshi, Nikhil

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Interaction of Plasmacytoid Dendritic Cells and Myeloma Cells Trigger Tumor Promoting Transcriptional Changes in Multiple Myeloma Cells by Ray, Arghya, Buon, Leutz, Song, Yan, Chauhan, Dharminder, Anderson, Kenneth C.

“…Introduction We have previously shown that increased numbers of plasmacytoid dendritic cells (pDCs) in bone marrow (BM) of multiple myeloma (MM) patients…”
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Multi-Level Control of Myeloma Cell Proliferation and Genomic Instability By the PDZ Binding Kinase (PBK) by Shi, Lai, Talluri, Srikanth, Kumar, Subodh, Zhao, Jiangning, Liao, Chengcheng, Buon, Leutz, Shi, DeYao, Mu, Shidai, Potluri, Lakshmi B., Chakraborty, Chandraditya, Shi, Jialan, Samur, Mehmet K., Shammas, Masood A., Munshi, Nikhil C

“…Genomic instability and cell proliferation play important roles in the development and progression of cancer. We identified a six-gene kinase signature that…”
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P-071: Exonuclease 1 co-operates with a pyrimidine synthetase to drive growth and genomic instability in multiple myeloma by Mu, Shidai, Talluri, Srikanth, Zhao, Jiangning, Buon, Leutz, Samur, Mehmet, Shammas, Masood, Munshi, Nikhil

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P-216 The PBK-FOXM1 axis disrupts the DREAM transcriptional repressor complex, contributing to the growth and genomic instability of myeloma by Shi, Lai, Talluri, Srikanth, Kumar, Subodh, Zhao, Jiangning, Potluri, Laksmi, Liao, Chengcheng, Buon, Leutz, Chakraborty, Chandraditya, Shammas, Masood, Munshi, Nikhil

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Plasmacytoid Dendritic Cells Trigger Contact-Dependent Tumor Promoting Genetic Alterations in Multiple Myeloma Cells by Ray, Arghya, Buon, Leutz, Song, Yan, Chauhan, Dharminder, Anderson, Kenneth C.

“…Introduction We identified an integral role of bone marrow (BM) plasmacytoid dendritic cells (pDCs) in multiple myeloma (MM) pathogenesis. Specifically, we…”
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Abstract NG14: Reduction in mitochondrial priming drives resistance to targeted therapy in acute myeloid leukemia by Bhatt, Shruti, Piosos, Marissa S., Olesinski, Elyse A., Yilma, Binyam G., Ryan, Jeremy A., Mashaka, Thelma, Leutz, Buon, Adamia, Sophia, Weinstock, David M., Garcia, Jacqueline S., Letai, Anthony

“…Relapse is the leading cause of treatment failure in acute myeloid leukemia (AML) patients. FDA approval of 8 targeted therapies in the past two years has…”
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ABL1 kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma by Kumar, Subodh, Talluri, Srikanth, Zhao, Jiangning, Liao, Chengcheng, Potluri, Lakshmi B., Buon, Leutz, Mu, Shidai, Shi, Jialan, Chakraborty, Chandraditya, Tai, Yu-Tzu, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.

“…•Elevated ABL1 kinase contributes to growth and dysregulation of HR and genome stability in myeloma.•Our data suggest that nilotinib, clinically approved ABL1…”
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Elevated APE1 Dysregulates Homologous Recombination and Cell Cycle Driving Genomic Evolution, Tumorigenesis, and Chemoresistance in Esophageal Adenocarcinoma by Kumar, Subodh, Zhao, Jiangning, Talluri, Srikanth, Buon, Leutz, Mu, Shidai, Potluri, Lakshmi B., Liao, Chengcheng, Shi, Jialan, Chakraborty, Chandraditya, Gonzalez, Gabriel B., Tai, Yu-Tzu, Patel, Jaymin, Pal, Jagannath, Mashimo, Hiroshi, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.

“…The purpose of this study was to identify drivers of genomic evolution in esophageal adenocarcinoma (EAC) and other solid tumors. An integrated genomics…”
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Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma by Potluri, Lakshmi B., Talluri, Srikanth, Buon, Leutz, Samur, Mehmet K., Aktas-Samur, Anil, Shi, Jialan, Chakraborty, Chandraditya, Kumar, Subodh, Prabhala, Rao, Shammas, Masood A., Munshi, Nikhil C.

“…Multiple myeloma (MM) is a genomically heterogenous malignancy characterized by a number of copy number alterations (CNA). Moreover, there is a clear evolution…”
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Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma by Liao, Chengcheng, Talluri, Srikanth, Kumar, Subodh, Buon, Leutz, Zhao, Jiangning, Potluri, Lakshmi B., Prabhala, Rao, Shammas, Masood A., Munshi, Nikhil C.

“…Multiple myeloma (MM) cells demonstrate significant genomic instability with acquisition of new genomic events over time. In an effort to decipher the pathways…”
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