Search Results - "Bunting, T."
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Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Published in Nature (London) (10-11-2016)“…Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic…”
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Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 + T-Cell Activation
Published in Frontiers in immunology (18-03-2019)“…Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8 T-cells, but little is…”
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Utility of Fluorescence In Situ Hybridization Panel for Myelodysplastic Syndrome in Evaluation of Cytopenia in a Pediatric Hospital: A 5-Year Retrospective Review and Utilization Management
Published in Laboratory medicine (01-08-2017)“…Abstract Background MDS FISH was routinely ordered together with chromosome analysis for patients with cytopenia in our hospital. The utility of MDS FISH in…”
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Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia
Published in Pediatric blood & cancer (01-09-2016)“…Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a subtype of T‐acute lymphoblastic leukemia (T‐ALL) arising from a primitive precursor. We…”
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Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site
Published in Journal of thrombosis and haemostasis (01-12-2013)“…Summary Background Ectodomain shedding of glycoprotein Ibα (GPIbα), a proteolytic event in which metalloprotease ADAM17 cleaves the Gly464‐Val465 bond and…”
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Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
Published in Case reports in hematology (08-09-2019)“…Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique…”
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Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement
Published in International journal of hematology (16-09-2024)“…Splenic marginal zone lymphoma (SMZL) is one of the most common B-cell lymphomas that affect the spleen. We report a case with splenomegaly and lymphocytosis…”
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Density Gradients in Canadian Metropolitan Regions, 1971-96: Differential Patterns of Central Area and Suburban Growth and Change
Published in Urban studies (Edinburgh, Scotland) (01-12-2002)“…This paper demonstrates that over the 25-year period, 1971-96, the majority of Canadian cities have undergone transition towards an increasingly decentralised…”
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Single-platelet nanomechanics measured by high-throughput cytometry
Published in Nature materials (01-02-2017)“…A high-throughput hydrogel-based platelet-contraction cytometer is able to quantify single-platelet contraction forces and may function as a clinical…”
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“Russell-like” bodies in Philadelphia chromosome–positive B-lymphoblastic leukemia
Published in Blood (17-04-2014)Get full text
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Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis
Published in Oncotarget (06-10-2015)“…Despite being an attractive molecular target for both lymphoid and myeloid leukemias characterized by activated tyrosine kinases, the molecular and…”
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A variant c‐KIT mutation, D816H, fundamental to the sequential development of an ovarian mixed germ cell tumor and systemic mastocytosis with chronic myelomonocytic leukemia
Published in Pediatric blood & cancer (01-04-2017)“…An activating point mutation of the c‐KIT tyrosine kinase receptor gene, D816H, has been described in germ cell tumors (GCTs). We report an adolescent…”
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ICCS Women in Cytometry—Impact 10 years later: A call to promote gender equity
Published in Cytometry. Part B, Clinical cytometry (01-05-2021)Get full text
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Case study interpretation—New Orleans: Case 1
Published in Cytometry. Part B, Clinical cytometry (01-09-2013)Get full text
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Disposable platform provides visual and color-based point-of-care anemia self-testing
Published in The Journal of clinical investigation (01-10-2014)“…Anemia, or low blood hemoglobin (Hgb) levels, afflicts 2 billion people worldwide. Currently, Hgb levels are typically measured from blood samples using…”
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Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model
Published in Blood (22-08-2013)“…Exposure to nonself red blood cell (RBC) antigens, either from transfusion or pregnancy, may result in alloimmunization and incompatible RBC clearance. First…”
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AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis
Published in Oncotarget (21-08-2015)“…AF1q is an MLL fusion partner that was identified from acute myeloid leukemia (AML) patients with t (1; 11) (q21; q23) chromosomal abnormality. The function of…”
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Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia
Published in Journal of translational medicine (12-06-2014)“…Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR…”
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Regulation of Insulin-Like Growth Factor I (IGF-I) Gene Expression in Brain of Transgenic Mice Expressing an IGF-I-Luciferase Fusion Gene
Published in Endocrinology (Philadelphia) (01-12-1997)“…Abstract Insulin-like growth factor I (IGF-I) plays an important role in the development and function of the central nervous system (CNS). Little is known,…”
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