Search Results - "Bunting, Kevin D."

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained by KO, Jennifer S, RAYMAN, Patricia, IRELAND, Joanna, SWAIDANI, Shadi, GEQIANG LI, BUNTING, Kevin D, RINI, Brian, FINKE, James H, COHEN, Peter A

“…The antiangiogenic drug sunitinib is a receptor tyrosine kinase inhibitor with significant, yet not curative, therapeutic effects in metastatic renal cell…”
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The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential by Mi, Tian, Wang, Zhengqi, Bunting, Kevin D

“…Reactive oxygen species (ROS) are now recognized as important second messengers with roles in many aspects of signaling during leukemogenesis. They serve as…”
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Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement by Wang, Zhengqi, Li, Geqiang, Tse, William, Bunting, Kevin D.

“…Currently, there is a major need in hematopoietic stem cell (HSC) transplantation to develop reduced-intensity regimens that do not cause DNA damage and…”
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STAT5 signaling in normal and pathologic hematopoiesis by Bunting, Kevin D

“…Hematopoietic development is highly dependent upon cytokine/receptor initiated signaling pathways. Of those activated in hematopoietic cells, the Janus kinase…”
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Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism by Liu, Xia, Zheng, Hong, Yu, Wen-Mei, Cooper, Todd M., Bunting, Kevin D., Qu, Cheng-Kui

“…The difficulty in maintaining the reconstituting capabilities of hematopoietic stem cells (HSCs) in culture outside of the bone marrow microenvironment has…”
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Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence by Qing, Yulan, Wang, Zhengqi, Bunting, Kevin D., Gerson, Stanton L.

“…DNA repair is essential for hematopoietic stem cell (HSC) maintenance. Ku70 is a key component of the nonhomologous end-joining pathway, which is the major…”
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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis by Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Mali, Raghuveer Singh, Martin, Holly, Kobayashi, Michihiro, Vemula, Sasidhar, Canela, Victor H., Waskow, Emily R., Visconte, Valeria, Tiu, Ramon V., Smith, Catherine C., Shah, Neil, Bunting, Kevin D., Boswell, H. Scott, Liu, Yan, Chan, Rebecca J., Kapur, Reuben

“…Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms…”
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Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells by Metts, Jonathan, Bradley, Heath L., Wang, Zhengqi, Shah, Neil P., Kapur, Reuben, Arbiser, Jack L., Bunting, Kevin D.

“…Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid…”
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A novel IL-25 signaling pathway through STAT5 by Wu, Ling, Zepp, Jarod A, Qian, Wen, Martin, Bradley N, Ouyang, Wenjun, Yin, Weiguo, Bunting, Kevin D, Aronica, Mark, Erzurum, Serpil, Li, Xiaoxia

“…IL-25 is a member of the IL-17 family of cytokines that promotes Th2 cell-mediated inflammatory responses. IL-25 signals through a heterodimeric receptor…”
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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype by Sorrentino, Brian P, Zhou, Sheng, Schuetz, John D, Bunting, Kevin D, Colapietro, Anne-Marie, Sampath, Janardhan, Morris, John J, Lagutina, Irina, Grosveld, Gerard C, Osawa, Mitsujiro, Nakauchi, Hiromitsu

“…Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed…”
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A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells by Xu, Dan, Wang, Siying, Yu, Wen-Mei, Chan, Gordon, Araki, Toshiyuki, Bunting, Kevin D., Neel, Benjamin G., Qu, Cheng-Kui

“…Germline and somatic gain-of-function mutations in tyrosine phosphatase PTPN11 (SHP-2) are associated with juvenile myelomonocytic leukemia (JMML), a…”
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Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT by Mali, Raghuveer Singh, Ma, Peilin, Zeng, Li-Fan, Martin, Holly, Ramdas, Baskar, He, Yantao, Sims, Emily, Nabinger, Sarah, Ghosh, Joydeep, Sharma, Namit, Munugalavadla, Veerendra, Chatterjee, Anindya, Li, Shuo, Sandusky, George, Craig, Andrew W., Bunting, Kevin D., Feng, Gen-Sheng, Chan, Rebecca J., Zhang, Zhong-Yin, Kapur, Reuben

“…Intracellular mechanism(s) that contribute to promiscuous signaling via oncogenic KIT in systemic mastocytosis and acute myelogenous leukemia are poorly…”
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STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease by Li, Geqiang, Miskimen, Kristy L., Wang, Zhengqi, Xie, Xiu Yan, Brenzovich, Jennifer, Ryan, John J., Tse, William, Moriggl, Richard, Bunting, Kevin D.

“…Phosphorylated signal transducer and activator of transcription 5 (STAT5) is a biomarker and potential molecular target for hematologic malignancies. We have…”
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Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 + T-Cell Activation by Wang, Zhengqi, Vaughan, Tamisha Y, Zhu, Wandi, Chen, Yuhong, Fu, Guoping, Medrzycki, Magdalena, Nishio, Hikaru, Bunting, Silvia T, Hankey-Giblin, Pamela A, Nusrat, Asma, Parkos, Charles A, Wang, Demin, Wen, Renren, Bunting, Kevin D

“…Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8 T-cells, but little is…”
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Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway by Fernando, Josephine, Faber, Travis W, Pullen, Nicholas A, Falanga, Yves T, Kolawole, Elizabeth Motunrayo, Oskeritzian, Carole A, Barnstein, Brian O, Bandara, Geethani, Li, Geqiang, Schwartz, Lawrence B, Spiegel, Sarah, Straus, David B, Conrad, Daniel H, Bunting, Kevin D, Ryan, John J

“…We previously demonstrated that TGF-β1 suppresses IgE-mediated signaling in human and mouse mast cells in vitro, an effect that correlated with decreased…”
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Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation by Friedbichler, Katrin, Kerenyi, Marc A., Kovacic, Boris, Li, Geqiang, Hoelbl, Andrea, Yahiaoui, Saliha, Sexl, Veronika, Müllner, Ernst W., Fajmann, Sabine, Cerny-Reiterer, Sabine, Valent, Peter, Beug, Hartmut, Gouilleux, Fabrice, Bunting, Kevin D., Moriggl, Richard

“…Stat5 transcription factors are essential gene regulators promoting proliferation, survival, and differentiation of all hematopoietic cell types. Mutations or…”
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Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia by Wang, Zhengqi, Mi, Tian, Bradley, Heath L., Metts, Jonathan, Sabnis, Himalee, Zhu, Wandi, Arbiser, Jack, Bunting, Kevin D.

“…Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are…”
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Cited2 is required for normal hematopoiesis in the murine fetal liver by Chen, Yu, Haviernik, Peter, Bunting, Kevin D., Yang, Yu-Chung

“…Cited2 (cAMP-responsive elementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]–rich tail 2) is a newly…”
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Multiple Apoptotic Defects in Hematopoietic Cells from Mice Lacking Lipocalin 24p3 by Liu, Zhuoming, Yang, Amy, Wang, Zhengqi, Bunting, Kevin D., Davuluri, Gangarao, Green, Michael R., Devireddy, Laxminarayana R.

“…The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis, iron trafficking, development and innate immunity…”
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Stat5 Expression Is Required for IgE-Mediated Mast Cell Function by Barnstein, Brian O, Li, Geqiang, Wang, Zhengqi, Kennedy, Sarah, Chalfant, Charles, Nakajima, Hiroshi, Bunting, Kevin D, Ryan, John J

“…The mast cell (MC) inflammatory response is now linked not only to atopy, but also to arthritis, multiple sclerosis, heart disease, and resistance to bacterial…”
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