Search Results - "Bunney, Blynn G."

Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms by Bunney, Blynn G, Bunney, William E

“…A significant subset of both major depressive disorder and bipolar disorder patients rapidly (within 24 hours) and robustly improves with the chronotherapeutic…”
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A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex by Orozco-Solis, Ricardo, Montellier, Emilie, Aguilar-Arnal, Lorena, Sato, Shogo, Vawter, Marquis P, Bunney, Blynn G, Bunney, William E, Sassone-Corsi, Paolo

“…Abstract Background Conventional antidepressants usually require several weeks to achieve a full clinical response in patients with major depressive disorder…”
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Circadian patterns of gene expression in the human brain and disruption in major depressive disorder by Li, Jun Z., Bunney, Blynn G., Meng, Fan, Hagenauer, Megan H., Walsh, David M., Vawter, Marquis P., Evans, Simon J., Choudary, Prabhakara V., Cartagena, Preston, Barchas, Jack D., Schatzberg, Alan F., Jones, Edward G., Myers, Richard M., Watson, Stanley J., Akil, Huda, Bunney, William E.

“…A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock…”
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Post-mortem molecular profiling of three psychiatric disorders by Ramaker, Ryne C, Bowling, Kevin M, Lasseigne, Brittany N, Hagenauer, Megan H, Hardigan, Andrew A, Davis, Nicholas S, Gertz, Jason, Cartagena, Preston M, Walsh, David M, Vawter, Marquis P, Jones, Edward G, Schatzberg, Alan F, Barchas, Jack D, Watson, Stanley J, Bunney, Blynn G, Akil, Huda, Bunney, William E, Li, Jun Z, Cooper, Sara J, Myers, Richard M

“…Psychiatric disorders are multigenic diseases with complex etiology that contribute significantly to human morbidity and mortality. Although clinically…”
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Rapid-acting antidepressant strategies: mechanisms of action by Bunney, Blynn G., Bunney, William E.

“…Current antidepressants are ineffective in many depressed patients. Thus there is an urgent need to develop treatment strategies which have significantly…”
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A study of psychological pain in substance use disorder and its relationship to treatment outcome by Mee, Steven, Bunney, Blynn G, Fujimoto, Ken, Penner, John, Seward, Garrett, Crowfoot, Keeley, Bunney, William E, Reist, Christopher

“…Substance Use Disorder (SUD) is a major public health concern affecting an estimated 22.5 million individuals in the United States. The primary aim of this…”
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Assessment of psychological pain in suicidal veterans by Reist, Christopher, Mee, Steven, Fujimoto, Ken, Rajani, Vivek, Bunney, William E, Bunney, Blynn G

“…Psychological pain is a relatively understudied and potentially important construct in the evaluation of suicidal risk. Psychological pain also referred to as…”
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Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression by Bellet, Marina M, Vawter, Marquis P, Bunney, Blynn G, Bunney, William E, Sassone-Corsi, Paolo

“…Major mood disorders have been linked to abnormalities in circadian rhythms, leading to disturbances in sleep, mood, temperature, and hormonal levels. We…”
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Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination by Savva, Christina, Vlassakev, Ivan, Bunney, Blynn G., Bunney, William E., Massier, Lucas, Seldin, Marcus, Sassone-Corsi, Paolo, Petrus, Paul, Sato, Shogo

“…Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption of circadian rhythms increases the risk of developing both…”
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Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia by Medina, Adriana M., Hagenauer, Megan Hastings, Krolewski, David M., Hughes, Evan, Forrester, Liam Cannon Thew, Walsh, David M., Waselus, Maria, Richardson, Evelyn, Turner, Cortney A., Sequeira, P. Adolfo, Cartagena, Preston M., Thompson, Robert C., Vawter, Marquis P., Bunney, Blynn G., Myers, Richard M., Barchas, Jack D., Lee, Francis S., Schatzberg, Alan F., Bunney, William E., Akil, Huda, Watson, Stanley J.

“…The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes…”
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Microarray Technology: A Review of New Strategies to Discover Candidate Vulnerability Genes in Psychiatric Disorders by Bunney, William E., Bunney, Blynn G., Vawter, Marquis P., Tomita, Hiroaki, Li, Jun, Evans, Simon J., Choudary, Prabhakara V., Myers, Richard M., Jones, Edward G., Watson, Stanley J., Akil, Huda

“…OBJECTIVE: An international effort is in progress to discover candidate genes and pathways associated with psychiatric disorders, including two of the most…”
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Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock by Sato, Shogo, Bunney, Blynn G., Vawter, Marquis P., Bunney, William E., Sassone-Corsi, Paolo

“…•Homer1a, but not the long variant of the Homer1 gene, exhibits robust circadian oscillation in mouse brain.•Circadian oscillation of Homer1a gene is…”
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Multiomic profiling of transcription factor binding and function in human brain by Loupe, Jacob M., Anderson, Ashlyn G., Rizzardi, Lindsay F., Rodriguez-Nunez, Ivan, Moyers, Belle, Trausch-Lowther, Katie, Jain, Rashmi, Bunney, William E., Bunney, Blynn G., Cartagena, Preston, Sequeira, Adolfo, Watson, Stanley J., Akil, Huda, Cooper, Gregory M., Myers, Richard M.

“…Transcription factors (TFs) orchestrate gene expression programs crucial for brain function, but we lack detailed information about TF binding in human brain…”
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Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder by Wu, Joseph C, Kelsoe, John R, Schachat, Carol, Bunney, Blynn G, DeModena, Anna, Golshan, Shahrokh, Gillin, J. Christian, Potkin, Steven G, Bunney, William E

“…Background The development of a rapid-acting and sustainable treatment for bipolar disorder (BPD) depression has been a goal for decades. The most widely…”
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Effect of Clozapine and Adjunctive High-Dose Glycine in Treatment-Resistant Schizophrenia by Potkin, Steven G., Jin, Yi, Bunney, Blynn G., Costa, Jerome, Gulasekaram, Bala

“…OBJECTIVE: The focus of this study was the systematic evaluation of the clinical effects of glycine as an adjunct to the atypical antipsychotic clozapine in…”
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Allele specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs by Anderson, Ashlyn G, Moyers, Belle A, Loupe, Jacob M, Rodriguez-Nunez, Ivan, Felker, Stephanie A, Lawlor, James M J, Bunney, William E, Bunney, Blynn G, Cartagena, Preston M, Sequeira, Adolfo, Watson, Stanley, Akil, Huda, Mendenhall, Eric M, Cooper, Gregory M, Myers, Richard M

“…Transcription Factors (TFs) regulate gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic…”
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Assessment of psychological pain in major depressive episodes by Mee, Steven, Bunney, Blynn G, Bunney, William E, Hetrick, William, Potkin, Steven G, Reist, Christopher

“…Abstract Severe psychological or mental pain is defined as an experience of unbearable torment which can be associated with a psychiatric illness (e.g., major…”
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Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements by Anderson, Ashlyn G., Rogers, Brianne B., Loupe, Jacob M., Rodriguez-Nunez, Ivan, Roberts, Sydney C., White, Lauren M., Brazell, J. Nicholas, Bunney, William E., Bunney, Blynn G., Watson, Stanley J., Cochran, J. Nicholas, Myers, Richard M., Rizzardi, Lindsay F.

“…Cell type-specific transcriptional differences between brain tissues from donors with Alzheimer’s disease (AD) and unaffected controls have been well…”
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Usage of Therapeutic Sleep Deprivation: A Survey in Psychiatric Hospitals in Austria, Germany, and Switzerland by Winkler, Dietmar, Spies, Marie, Al-Resheg, Yasmin, Wu, Joseph C., Bunney, William E., Bunney, Blynn G., Kasper, Siegfried, Pjrek, Edda

“…Objective: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is used most often for depression. The aim of this study was to examine…”
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Psychological pain: A review of evidence by Mee, Steven, Bunney, Blynn G., Reist, Christopher, Potkin, Steve G., Bunney, William E.

“…This paper defines a symptom construct termed psychological pain and reviews clinical and neuroimaging evidence relevant to it. The psychological pain…”
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