Search Results - "Bunn, Robert C."

Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis by Hughes, Corey B., Mussman, George M., Ray, Phil, Bunn, Robert C., Cornea, Virgilius, Thrailkill, Kathryn M., Fowlkes, John L., Popescu, Iuliana

“…Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect…”
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Matrix Metalloproteinase-2 Dysregulation in Type 1 Diabetes by Thrailkill, Kathryn M, Bunn, Robert C, Moreau, Cynthia S, Cockrell, Gael E, Simpson, Pippa M, Coleman, Hannah N, Frindik, J. Paul, Kemp, Stephen F, Fowlkes, John L

“…OBJECTIVE:--Dysregulation of matrix metalloproteinase (MMP)-2 may contribute pathologically to the development of diabetes complications, including diabetic…”
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Palmitate and insulin synergistically induce IL-6 expression in human monocytes by Bunn, Robert C, Cockrell, Gael E, Ou, Yang, Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Fowlkes, John L

“…Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and…”
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Cisplatin inhibits bone healing during distraction osteogenesis by Stine, Kimo C., Wahl, Elizabeth C., Liu, Lichu, Skinner, Robert A., VanderSchilden, Jacquelyn, Bunn, Robert C., Montgomery, Corey O., Suva, Larry J., Aronson, James, Becton, David L., Nicholas, Richard W., Swearingen, Christopher J., Lumpkin Jr, Charles K.

“…ABSTRACT Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of…”
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Bone Formation Is Impaired in a Model of Type 1 Diabetes by THRAILKILL, Kathryn M, LICHU LIU, ARONSON, James, LUMPKIN, Charles K, WAHL, Elizabeth C, BUNN, Robert C, PERRIEN, Daniel S, COCKRELL, Gael E, SKINNER, Robert A, HOGUE, William R, CARVER, Adam A, FOWLKES, John L

“…Bone Formation Is Impaired in a Model of Type 1 Diabetes Kathryn M. Thrailkill 1 , Lichu Liu 2 , Elizabeth C. Wahl 2 , Robert C. Bunn 1 , Daniel S. Perrien 3 4…”
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Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model by Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K

“…DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local…”
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Heterogeneity and altered β-cell identity in the TallyHo model of early-onset type 2 diabetes by McDonald, Sarah, Ray, Phil, Bunn, Robert C., Fowlkes, John L., Thrailkill, Kathryn M., Popescu, Iuliana

“…A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2…”
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Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97 by Klöcker, Nikolaj, Bunn, Robert C., Schnell, Eric, Caruana, Georgina, Bernstein, Alan, Nicoll, Roger A., Bredt, David S.

“…Postsynaptic targeting of the Drosophila tumour suppressor discs‐large (Dlg) critically depends on its SH3 and GK domains. Here, we asked whether these domains…”
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Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity by Stine, Kimo C., Wahl, Elizabeth C., Liu, Lichu, Skinner, Robert A., VanderSchilden, Jaclyn, Bunn, Robert C., Montgomery, Corey O., Aronson, James, Becton, David L., Nicholas, Richard W., Swearingen, Christopher J., Suva, Larry J., Lumpkin, Charles K.

“…ABSTRACT The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols…”
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Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus by Thrailkill, Kathryn M., Moreau, Cynthia S., Cockrell, Gael E., Jo, Chan-Hee, Bunn, Robert C., Morales-Pozzo, Alba E., Lumpkin, Charles K., Fowlkes, John L.

“…Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal injury, can bind matrix metalloproteinase-9 (MMP-9) and inhibit its degradation,…”
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Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Clark, Lindsey M, Ou, Yang, Isales, Carlos M, Badger, Thomas M, Ronis, Martin J, Sims, John, Lumpkin, Charles K

“…Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised…”
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GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP by Reed, Brent C, Cefalu, Christopher, Bellaire, Bryan H, Cardelli, James A, Louis, Thomas, Salamon, Joanna, Bloecher, Mari Anne, Bunn, Robert C

“…We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it…”
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Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms by Chetkovich, Dane M, Bunn, Robert C, Kuo, Sheng-Han, Kawasaki, Yoshimi, Kohwi, Minoree, Bredt, David S

“…Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein…”
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Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Ronis, Martin J.J, Lumpkin, Charles K

“…Abstract Distraction osteogenesis (DO) is a process which induces direct new bone formation as a result of mechanical distraction. Tumor necrosis factor-α…”
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A novel rat model for the study of deficits in bone formation in type-2 diabetes by Liu, Zhendong, Aronson, James, Wahl, Elizabeth C, Liu, Lichu, Perrien, Daniel S, Kern, Phillip A, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Cockrell, Gael E, Skinner, Robert A, Lumpkin, Jr, Charles K

“…There is evidence to suggest that impairment in bone formation and/or turnover is associated with the metabolic abnormalities characteristic of type-2 diabetes…”
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Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology by Thrailkill, Kathryn M, Moreau, Cindy S, Cockrell, Gael, Simpson, Pippa, Goel, Rajiv, North, Paula, Fowlkes, John L, Bunn, Robert C

“…Matrix metalloproteinases are a family of zinc-dependent proteinases which are involved in the breakdown and remodeling of extracellular matrix. As children…”
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Implications for matrix metalloproteinases as modulators of pediatric lung disease by Winkler, Margaret K, Foldes, Jane K, Bunn, Robert C, Fowlkes, John L

“…Matrix metalloproteinases (MMPs) are a large family (>20) of cation-dependent proteinases believed to be important modulators of normal human lung development…”
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Actinin-Associated LIM Protein-Deficient Mice Maintain Normal Development and Structure of Skeletal Muscle by Jo, Kiwon, Rutten, Bart, Bunn, Robert C., Bredt, David S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chronic ethanol exposure is associated with a local increase in TNF-α and decreased proliferation in the rat distraction gap by Perrien, Daniel S., Liu, Zhendong, Wahl, Elizabeth C., Bunn, Robert C., Skinner, Robert A., Aronson, James, Fowlkes, John, Badger, Thomas M., Lumpkin, Charles K.

“…Chronic alcohol consumption is a risk factor for osteoporosis and inhibits osseous repair and regeneration. We investigated the hypothesis that chronic ethanol…”
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C-terminal Mutations That Alter the Turnover Number for 3-O-Methylglucose Transport by GLUT1 and GLUT4 (∗) by Dauterive, Robin, Laroux, Stephen, Bunn, Robert C., Chaisson, Audra, Sanson, Trudy, Reed, Brent C.

“…Turnover numbers for 3-O-methylglucose transport by the homologous glucose transporters GLUT1 and GLUT4 were compared to those for truncated and chimeric…”
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