Search Results - "Bunn, H F"

Oxygen sensing and molecular adaptation to hypoxia by Bunn, H F, Poyton, R O

“…This review focuses on the molecular stratagems utilized by bacteria, yeast, and mammals in their adaptation to hypoxia. Among this broad range of organisms,…”
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Pathogenesis and Treatment of Sickle Cell Disease by Bunn, H. Franklin

“…In 1949, the discovery that sickle hemoglobin (α 2 βS 2 ) has an abnormal electrophoretic mobility prompted Linus Pauling and his colleagues to christen sickle…”
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Regulation of the erythropoietin gene by EBERT, B. L, BUNN, H. F

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Induction of Fetal Hemoglobin in Sickle Cell Disease by Bunn, H. Franklin

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In Vivo and In Vitro Regulation of Erythropoietin mRNA: Measurement by Competitive Polymerase Chain Reaction by Fandrey, Joachim, Bunn, H. Franklin

“…The regulation of erythropoietin (Epo) production was investigated by competitive polymerase chain reaction, a highly sensitive and accurate means of measuring…”
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Classification of the disorders of hemoglobin by Forget, Bernard G, Bunn, H Franklin

“…Over the years, study of the disorders of hemoglobin has served as a paradigm for gaining insights into the cellular and molecular biology, as well as the…”
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Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements by BLANCHARD, K. L, ACQUAVIVA, A. M, GALSON, D. L, BUNN, H. F

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Clonality in Myeloproliferative Disorders: Analysis by Means of the Polymerase Chain Reaction by Gilliland, D. Gary, Blanchard, Kerry L., Levy, Joanne, Perrin, Steven, Bunn, H. Franklin

“…The myeloproliferative syndromes are acquired disorders of hematopoiesis that provide insights into the transition from somatic cell mutation to neoplasia. The…”
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Erythropoietin Structure-Function Relationships: High Degree of Sequence Homology Among Mammals by Wen, Danyi, Boissel, Jean-Paul R., Tracy, Timothy E., Gruninger, Robert H., Mulcahy, Linda S., Czelusniak, John, Goodman, Morris, Bunn, H. Franklin

“…To investigate structure-function relationships of erythropoietin (Epo), we have obtained cDNA sequences that encode the mature Epo protein of a variety of…”
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Regulation of the Erythropoietin Gene: Evidence that the Oxygen Sensor is a Heme Protein by Goldberg, Mark A., Dunning, Susan P., Bunn, H. Franklin

“…Erythropoietin (Epo), the hormone that stimulates red blood cell production, is synthesized in the kidney and liver in response to hypoxia. The human hepatoma…”
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Erythropoietin mRNA Levels Are Governed by Both the Rate of Gene Transcription and Posttranscriptional Events by Goldberg, Mark A., Gaut, Christopher C., Bunn, H. Franklin

“…The human hepatoma cell line, Hep3B. synthesizes large quantities of erythropoietin (Epo) mRNA and protein in a regulated manner in response to hypoxia and…”
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Nonenzymatic glycosylation of human serum albumin alters its conformation and function by Shaklai, N, Garlick, R L, Bunn, H F

“…Approximately 10% of the albumin in normal human serum is modified by nonenzymatic glycosylation, primarily at the epsilon-amino group of lysine residue 525…”
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The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1 by Galson, Deborah L., Tsuchiya, Terumasa, Tendler, Drory S., Huang, L. Eric, Ren, Yan, Ogura, Toshihiko, Bunn, H. Franklin

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Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure by Boissel, J P, Lee, W R, Presnell, S R, Cohen, F E, Bunn, H F

“…On the basis of its primary sequence and the location of its disulfide bonds, we propose a structural model of the erythropoietic hormone erythropoietin (Epo)…”
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The Regulated Expression of Erythropoietin by Two Human Hepatoma Cell Lines by Goldberg, Mark A., Glass, G. Allison, Cunningham, James M., Bunn, H. Franklin

“…The development of a cell culture system that produces erythropoietin (Epo) in a regulated manner has been the focus of much effort. We have screened multiple…”
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Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin by Boissel, J P, Kasper, T J, Bunn, H F

“…The diversity of protein structure is significantly enhanced by cotranslational and posttranslational modifications. Structural features at the amino terminus…”
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Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit by Huang, L. Eric, Arany, Zoltan, Livingston, David M., Bunn, H. Franklin

“…Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for hypoxic induction of a number of physiologically important…”
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Signal transduction. How do cells sense oxygen? by Zhu, H, Bunn, H F

“…How do organisms sense the amount of oxygen in the environment and respond appropriately when the amount of oxygen decreases (a condition called hypoxia)? In…”
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Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein by RONDON, I. J, MACMILLAN, L. A, BECKMAN, B. S, GOLDBERG, M. A, SCHNEIDER, T, BUNN, H. F, MALTER, J. S

“…The mechanisms which control the production of erythropoietin (Epo) remain enigmatic. Recent data suggest that the half-time of Epo messenger RNA (mRNA) is…”
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Erythropoietin structure-function relationships. Identification of functionally important domains by Wen, D, Boissel, J P, Showers, M, Ruch, B C, Bunn, H F

“…In order to delineate functionally important domains in erythropoietin (Epo), we have prepared and tested a series of amino acid replacements at 51 conserved…”
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