Search Results - "Bunker, D."

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN by Sievers, Quinlan L, Petzold, Georg, Bunker, Richard D, Renneville, Aline, Słabicki, Mikołaj, Liddicoat, Brian J, Abdulrahman, Wassim, Mikkelsen, Tarjei, Ebert, Benjamin L, Thomä, Nicolas H

“…The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros…”
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Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks by Schmitges, Frank W., Prusty, Archana B., Faty, Mahamadou, Stützer, Alexandra, Lingaraju, Gondichatnahalli M., Aiwazian, Jonathan, Sack, Ragna, Hess, Daniel, Li, Ling, Zhou, Shaolian, Bunker, Richard D., Wirth, Urs, Bouwmeester, Tewis, Bauer, Andreas, Ly-Hartig, Nga, Zhao, Kehao, Chan, Homan, Gu, Justin, Gut, Heinz, Fischle, Wolfgang, Müller, Jürg, Thomä, Nicolas H.

“…The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2…”
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Mechanisms of OCT4-SOX2 motif readout on nucleosomes by Michael, Alicia K, Grand, Ralph S, Isbel, Luke, Cavadini, Simone, Kozicka, Zuzanna, Kempf, Georg, Bunker, Richard D, Schenk, Andreas D, Graff-Meyer, Alexandra, Pathare, Ganesh R, Weiss, Joscha, Matsumoto, Syota, Burger, Lukas, Schübeler, Dirk, Thomä, Nicolas H

“…Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs…”
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p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions by Harton, Marie D, Koh, Woo Seuk, Bunker, Amie D, Singh, Abhyudai, Batchelor, Eric

“…The p53 tumor suppressor regulates distinct responses to cellular stresses. Although different stresses generate different p53 dynamics, the mechanisms by…”
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Crystal structure of the human COP9 signalosome by Lingaraju, Gondichatnahalli M., Bunker, Richard D., Cavadini, Simone, Hess, Daniel, Hassiepen, Ulrich, Renatus, Martin, Fischer, Eric S., Thomä, Nicolas H.

“…Ubiquitination is a crucial cellular signalling process, and is controlled on multiple levels. Cullin–RING E3 ubiquitin ligases (CRLs) are regulated by the…”
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Population Structure of German Cockroaches (Blattodea: Ectobiidae) in an Urban Environment Based on Single Nucleotide Polymorphisms by Fan, X., Wang, C., Bunker, D. E.

“…German cockroaches (Blattella germanica L.) harbor and disperse medically important pathogens and are a source of allergens that impact human health and…”
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Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions by Shi, Tianlai, Bunker, Richard D., Mattarocci, Stefano, Ribeyre, Cyril, Faty, Mahamadou, Gut, Heinz, Scrima, Andrea, Rass, Ulrich, Rubin, Seth M., Shore, David, Thomä, Nicolas H.

“…Yeast telomeres comprise irregular TG1-3 DNA repeats bound by the general transcription factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a…”
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No evidence of impediment by three common classes of prescription drugs to post-stroke aphasia recovery in a retrospective longitudinal sample by Stockbridge, Melissa D, Keser, Zafer, Bunker, Lisa D, Hillis, Argye E

“…A number of pharmaceuticals have been identified as potential adjuvants to speech language therapy following stroke, but it is also important to consider which…”
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Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization by Chiu, Elaine, Hijnen, Marcel, Bunker, Richard D., Boudes, Marion, Rajendran, Chitra, Aizel, Kaheina, Oliéric, Vincent, Schulze-Briese, Clemens, Mitsuhashi, Wataru, Young, Vivienne, Ward, Vernon K., Bergoin, Max, Metcalf, Peter, Coulibaly, Fasséli

“…The great benefits that chemical pesticides have brought to agriculture are partly offset by widespread environmental damage to nontarget species and threats…”
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The transcriptional response to tumorigenic polarity loss in Drosophila by Bunker, Brandon D, Nellimoottil, Tittu T, Boileau, Ryan M, Classen, Anne K, Bilder, David

“…Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains…”
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Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser by Gati, Cornelius, Oberthuer, Dominik, Yefanov, Oleksandr, Bunker, Richard D., Stellato, Francesco, Chiu, Elaine, Yeh, Shin-Mei, Aquila, Andrew, Basu, Shibom, Bean, Richard, Beyerlein, Kenneth R., Botha, Sabine, Boutet, Sébastien, DePonte, Daniel P., Doak, R. Bruce, Fromme, Raimund, Galli, Lorenzo, Grotjohann, Ingo, James, Daniel R., Kupitz, Christopher, Lomb, Lukas, Messerschmidt, Marc, Nass, Karol, Rendek, Kimberly, Shoeman, Robert L., Wang, Dingjie, Weierstall, Uwe, White, Thomas A., Williams, Garth J., Zatsepin, Nadia A., Fromme, Petra, Spence, John C. H., Goldie, Kenneth N., Jehle, Johannes A., Metcalf, Peter, Barty, Anton, Chapman, Henry N.

“…To understand how molecules function in biological systems, new methods are required to obtain atomic resolution structures from biological material under…”
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A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling by Bilder, David, Vaccari, Thomas, Bunker, Brandon D, Classen, Anne-Kathrin, Harvey, Kieran F

“…A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points…”
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A novel framework to generate plant functional groups for ecological modelling by Calbi, M., Boenisch, G., Boulangeat, I., Bunker, D., Catford, J.A., Changenet, A., Culshaw, V., Dias, A.S., Hauck, T., Joschinski, J., Kattge, J., Mimet, A., Pianta, M., Poschlod, P., Weisser, W.W., Roccotiello, E.

“…•We propose a novel framework to generate Plant Functional Groups (PFGs) for ecological modelling.•We devised a workflow that ecompasses data preparation,…”
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Hyperintense vessels on imaging account for neurological function independent of lesion volume in acute ischemic stroke by Bunker, Lisa D., Walker, Alexandra, Meier, Erin, Goldberg, Emily, Leigh, Richard, Hillis, Argye E.

“…•Studies have revealed variable significance of FLAIR hyperintense vessels (FHV).•We found number and location of FHV are associated with functional…”
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functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography by Bunker, Richard D, Mandal, Kalyaneswar, Bashiri, Ghader, Chaston, Jessica J, Pentelute, Bradley L, Lott, J Shaun, Kent, Stephen B H, Baker, Edward N

“…Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from…”
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Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction by Bunker, Kevin D, Sach, Neal W, Huang, Qinhua, Richardson, Paul F

“…The reaction of [1.1.1]propellane with di-tert-butyl azodicarboxylate and phenylsilane in the presence of Mn(dpm)3 to give di-tert-butyl…”
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Crystal Structure of the Minor Pilin FctB Reveals Determinants of Group A Streptococcal Pilus Anchoring by Linke, Christian, Young, Paul G., Kang, Hae Joo, Bunker, Richard D., Middleditch, Martin J., Caradoc-Davies, Tom T., Proft, Thomas, Baker, Edward N.

“…Cell surface pili are polymeric protein assemblies that enable bacteria to adhere to surfaces and to specific host tissues. The pili expressed by Gram-positive…”
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Open surgical release for frozen shoulder: Surgical findings and results of the release by Omari, Abdullah, Bunker, Timothy D.

“…Over a 5-year period, 75 shoulders that met Codman's criteria for primary frozen shoulder were treated. Nine patients improved with nonoperative treatment, and…”
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The influence of an all-female healthcare environment on mentorship and empowerment of female healthcare professionals by Munabi, Naikhoba C O, Auslander, Allyn, Xepoleas, Meredith D, Bunker, Libby D, Vangsness, Kella L, Koualla, Sara, Magee, Kathy S, Magee, 3rd, William P, Yao, Caroline A

“…Low- and middle-income countries (LMICs) have the greatest need for additional healthcare providers, and women outside the workforce help address the need…”
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Arthroscopic capsular release for idiopathic frozen shoulder with intra-articular injection and a controlled manipulation by Smith, C D, Hamer, P, Bunker, T D

“…The aim of this prospective study was to assess the immediate and long-term effectiveness of arthroscopic capsular release in a large cohort of patients with a…”
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