Search Results - "Bunger, Rolf"

Metabolomics and Receiver Operating Characteristic Analysis: A Promising Approach for Sepsis Diagnosis by Bünger, Rolf, Mallet, Robert T.

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Identifying Circulating and Lung Tissue Cytokines Associated with Thoracic Irradiation and AEOL 10150 Treatment in a Nonhuman Primate Model by Cui, Wanchang, Hankey, Kim G., Zhang, Pei, Bolduc, David L., Bünger, Rolf, Xiao, Mang, Farese, Ann M., MacVittie, Thomas J.

“…Inflammatory cytokines have been suggested to play important roles in radiation-induced lung injury (RILI). Identifying significantly changed circulating and…”
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Pyruvate-enriched resuscitation for shock by Mallet, Robert T, Olivencia-Yurvati, Albert H, Bünger, Rolf

“…This commentary addresses the recent retraction of an article which reported favorable outcomes in septic patients treated with intravenous pyruvate. The…”
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Urine Interleukin-18 (IL-18) as a Biomarker of Total-Body Irradiation: A Preliminary Study in Nonhuman Primates by Xiao, Mang, Bolduc, David L., Li, XiangHong, Cui, Wanchang, Hieber, Kevin P., Bünger, Rolf, Ossetrova, Natalia I.

“…We have reported that circulating IL-18 can be used as a radiation biomarker in mice, minipigs and nonhuman primates (NHPs, Macaca mulatta). Here, we report…”
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MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG by Bolduc, David L, Bünger, Rolf, Moroni, Maria, Blakely, William F

“…Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create…”
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Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes by Romberg, Birgit, Metselaar, Josbert M., Baranyi, Lajos, Snel, Cor J., Bünger, Rolf, Hennink, Wim E., Szebeni, Janos, Storm, Gert

“…Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats…”
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Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state by Bassenge, E, Sommer, O, Schwemmer, M, Bünger, R

“…Myocardial ischemia-reperfusion is associated with bursts of reactive oxygen species (ROS) such as superoxide radicals (O(2)(-).). Membrane-associated NADH…”
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Adenosine enhances cytosolic phosphorylation potential and ventricular contractility in stunned guinea pig heart: receptor-mediated and metabolic protection by Schulze, Karsten, Duschek, Conrad, Lasley, Robert D, Bunger, Rolf

“…1 Abteilung für Kardiologie und Pneumologie, Campus Benjamin Franklin, Charité Berlin, Berlin, Germany; 2 Department of Physiology, Wayne State University…”
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Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application by Mallet, Robert T, Olivencia-Yurvati, Albert H, Bünger, Rolf

“…Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium’s high demand for oxygen and energy substrates leaves it acutely…”
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Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome by Szebeni, János, MD, PhD, DSc, Bedőcs, Péter, MD, Rozsnyay, Zoltán, MSc, PhD, Weiszhár, Zsóka, MSc, Urbanics, Rudolf, MD, PhD, Rosivall, László, MD, PhD, DSc, Cohen, Rivka, PhD, Garbuzenko, Olga, PhD, Báthori, György, MD, PhD, Tóth, Miklós, MD, PhD, DSc, Bünger, Rolf, MD, PhD, Barenholz, Yechezkel, PhD

“…Abstract Hypersensitivity reactions to liposomal drugs, often observed with Doxil and AmBisome, can arise from activation of the complement (C) system by…”
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A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines by Szebeni, János, Bedőcs, Péter, Csukás, Domokos, Rosivall, László, Bünger, Rolf, Urbanics, Rudolf

“…Intravenous administration of low (milligram) doses of nanoparticulate materials in pigs can lead to acute cardiopulmonary, hemodynamic, hematological,…”
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Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: A porcine model by Szebeni, János, Bedőcs, Péter, Urbanics, Rudolf, Bünger, Rolf, Rosivall, László, Tóth, Miklós, Barenholz, Yechezkel

“…PEGylated liposomal doxorubicin (Doxil) has been used in cancer chemotherapy for 16years. Clinical experience shows that it can cause mild-to-severe…”
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Pyruvate improves cerebral metabolism during hemorrhagic shock by Mongan, P D, Capacchione, J, Fontana, J L, West, S, Bünger, R

“…Pyruvate (PYR) improves cellular and organ function hypoxia and ischemia by stabilizing the reduced nicotinamide adenine dinucleotide redox state and cytosolic…”
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Intravenous pyruvate prolongs survival during hemorrhagic shock in swine by Mongan, P D, Fontana, J L, Chen, R, Bünger, R

“…Pyruvate improves cellular and organ function during hypoxia and ischemia and stabilizes the NADH redox state and cytosolic ATP phosphorylation potential. In…”
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The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium by Kristo, Gentian, Yoshimura, Yukihiro, Niu, Jianli, Keith, Byron J, Mentzer, Jr, Robert M, Bünger, Rolf, Lasley, Robert D

“…The intermediary metabolite pyruvate has been shown to exert significant beneficial effects in in vitro models of myocardial oxidative stress and…”
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Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice by Bhattacharya, Pratip, Chekmenev, Eduard Y., Reynolds, Wanda F., Wagner, Shawn, Zacharias, Niki, Chan, Henry R., Bünger, Rolf, Ross, Brian D.

“…MR techniques using hyperpolarized 13C have successfully produced examples of angiography and intermediary metabolic imaging, but, to date, no receptor imaging…”
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Porcine-specific hemoglobin saturation measurements by Serianni, Richard, Barash, Jed, Bentley, Timothy, Sharma, Pushpa, Fontana, John L, Via, Darin, Duhm, Jochen, Bunger, Rolf, Mongan, Paul D

“…Departments of 1  Anesthesiology and 4  Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; 2…”
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Profound Normovolemic Hemodilution: Hemostatic Effects in Patients and in a Porcine Model by McLoughlin, Thomas M., Fontana, John L., Alving, Barbara, Mongan, Paul D., Bunger, Rolf

“…Previous systematic investigations of the hemostatic effects of normovolemic hemodilution (NHD) have not explored the influence of hematocrits less than 20% in…”
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Animal Models of Complement-Mediated Hypersensitivity Reactions to Liposomes and Other Lipid-Based Nanoparticles by Szebeni, János, Alving, Carl R., Rosivall, László, Bünger, Rolf, Baranyi, Lajos, Bedöcs, Péter, Tóth, Miklós, Barenholz, Yezheckel

“…Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions…”
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Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function by Szebeni, János, Baranyi, Lajos, Sávay, Sándor, Bodó, Michael, Milosevits, János, Alving, Carl R, Bünger, Rolf

“…Cardiac anaphylaxis is a severe, life-threatening manifestation of acute hypersensitivity reactions to allergens and drugs. Earlier studies highlighted an…”
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