Search Results - "Bungay, P. J."

Functional Coupling of Endogenous Serotonin (5‐HT1B) and Calcitonin (C1a) Receptors in CHO Cells to a Cyclic AMP‐Responsive Luciferase Reporter Gene by George, S. E., Bungay, P. J., Naylor, L. H.

“…: A cyclic AMP‐responsive reporter cell line has been established through the stable expression of a luciferase reporter plasmid in Chinese hamster ovary (CHO)…”
Get full text

A role for transglutaminase in glucose-stimulated insulin release from the pancreatic beta-cell by Bungay, P J, Owen, R A, Coutts, I C, Griffin, M

“…Preincubation of rat islets of Langerhans with the potent inhibitors of islet transglutaminase activity, monodansylcadaverine (30-100 microM) and…”
Get full text

The inhibition of glucose-stimulated insulin secretion by primary amines. A role for transglutaminase in the secretory mechanism by Bungay, P J, Potter, J M, Griffin, M

“…Rat pancreatic islets contain a Ca2+-activated and thiol-dependent transglutaminase (EC 2.3.2.13) comparable in activity with that found in rat liver, lung and…”
Get full text

Alterations in the distribution and activity of transglutaminase during tumour growth and metastasis by Barnes, R N, Bungay, P J, Elliott, B M, Walton, P L, Griffin, M

“…Transglutaminase activity and subcellular distribution have been examined in both normal and tumour tissue. Subcellular fractionation of rat liver demonstrated…”
Get more information

Transglutaminase-catalysed cross-linking of proteins phosphorylated in the intact glucose-stimulated pancreatic beta-cell by Owen, R A, Bungay, P J, Hussain, M, Griffin, M

“…Incubation of intact islets in the presence of [32P]Pi and stimulatory levels of glucose followed by separation of phosphorylated islet proteins by…”
Get more information

Activation of transglutaminase at calcium levels consistent with a role for this enzyme as a calcium receptor protein by Hand, D, Bungay, P J, Elliott, B M, Griffin, M

“…The sensitivity of tissue transglutaminase to activation by Ca2+ and other cellular factors was investigated using the enzyme purified from rat liver. The…”
Get more information

A role for polyamines in stimulus-secretion coupling in the pancreatic beta-cell by Bungay, P J, Potter, J M, Griffin, M

“…Measurement of the content of polyamines in pancreatic islets indicated that no significant change in their concentration took place during glucose-stimulated…”
Get more information

Functional analysis of the D2L dopamine receptor expressed in a cAMP-responsive luciferase reporter cell line by GEORGE, S. E, BUNGAY, P. J, NAYLOR, L. H

“…A Chinese hamster ovary (CHO) cell line expressing the firefly luciferase gene under the control of six cAMP response elements (CREs) was stably transfected…”
Get full text

Partial agonism at serotonin 5-HT1B and dopamine D2L receptors using a luciferase reporter gene assay by KEMP, D. M, GEORGE, S. E, BUNGAY, P. J, NAYLOR, L. H

“…We have used a luciferase reporter gene assay to study the functional responses of two G-protein-coupled receptors in Chinese hamster ovary (CHO) cells. The…”
Get full text

The use of a biotin-labelled amine to identify endogenous substrates of transglutaminase in pancreatic islets by Smethurst, P A, Bungay, P J, Griffin, M

Get more information

Identification of the endogenous substrates of the pancreatic islet transglutaminase by Lindsay, M, Bungay, P J, Griffin, M

Get more information

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain by Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S

“…Hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), are…”
Get full text

Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands by Knoechel, Thorsten R, Tucker, Alec D, Robinson, Colin M, Phillips, Chris, Taylor, Wendy, Bungay, Peter J, Kasten, Shane A, Roche, Thomas E, Brown, David G

“…Pyruvate dehydrogenase kinase (PDHK) regulates the activity of the pyruvate dehydrogenase multienzyme complex. PDHK inhibition provides a route for therapeutic…”
Get full text

Functional Analysis of the D 2L Dopamine Receptor Expressed in a cAMP-Responsive Luciferase Reporter Cell Line by George, Samantha E, Bungay, Peter J, Naylor, Louise H

“…A Chinese hamster ovary (CHO) cell line expressing the firefly luciferase gene under the control of six cAMP response elements (CREs) was stably transfected…”
Get full text

The effect of ICER on screening methods involving CRE-mediated reporter gene expression by Kemp, Daniel M, George, Samantha E, Kent, Toby C, Bungay, Peter J, Naylor, Louise H

“…We describe a mechanism whereby increasing levels of cAMP in Chinese hamster ovary (CHO) and other cell lines lead to a significant repression in cAMP response…”
Get more information

Calmodulin involvement in Ca2(+)-induced insulin release from electropermeabilized islets of Langerhans by Smethurst, P A, Bungay, P J, Mireylees, S E, Griffin, M

Get more information

Transglutaminase involvement in the secretion of insulin from electropermeabilised rat islets of Langerhans by Lindsay, M A, Bungay, P J, Griffin, M

“…Ca(2+)-Induced insulin release from electropermeabilised islets is inhibited by the transglutaminase inhibitors monodansylcadaverine, glycine methylester,…”
Get more information

The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317 by Terrett, Nicholas K., Bojanic, Dejan, Brown, David, Bungay, Peter J., Gardner, Mark, Gordon, David W., Mayers, Carolyn J., Steele, John

“…A combinatorial library of 30,752 compounds has been synthesised from a set of 32 natural and unnatural amino acids. The library was designed to include the…”
Get full text