Search Results - "Bunck, Mirjam"

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice by Marsch, Rudolph, Foeller, Elisabeth, Rammes, Gerhard, Bunck, Mirjam, Kössl, Manfred, Holsboer, Florian, Zieglgänsberger, Walter, Landgraf, Rainer, Lutz, Beat, Wotjak, Carsten T

“…The transient receptor potential vanilloid type 1 channel (TRPV1) (formerly called vanilloid receptor VR1) is known for its key role of functions in sensory…”
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Proteomics and Metabolomics Analysis of a Trait Anxiety Mouse Model Reveals Divergent Mitochondrial Pathways by Filiou, Michaela D, Zhang, Yaoyang, Teplytska, Larysa, Reckow, Stefan, Gormanns, Philipp, Maccarrone, Giuseppina, Frank, Elisabeth, Kessler, Melanie S, Hambsch, Boris, Nussbaumer, Markus, Bunck, Mirjam, Ludwig, Tonia, Yassouridis, Alexander, Holsboer, Florian, Landgraf, Rainer, Turck, Christoph W

“…Background Although anxiety disorders are the most prevalent psychiatric disorders, no molecular biomarkers exist for their premorbid diagnosis, accurate…”
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Mice selected for high versus low stress reactivity: A new animal model for affective disorders by Touma, Chadi, Bunck, Mirjam, Glasl, Lisa, Nussbaumer, Markus, Palme, Rupert, Stein, Hendrik, Wolferstätter, Michael, Zeh, Ramona, Zimbelmann, Marina, Holsboer, Florian, Landgraf, Rainer

“…Summary Affective disorders such as major depression are among the most prevalent and costly diseases of the central nervous system, but the underlying…”
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Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety by Muigg, Patrik, Scheiber, Sandra, Salchner, Peter, Bunck, Mirjam, Landgraf, Rainer, Singewald, Nicolas

“…There is evidence for a disturbed perception and processing of emotional information in pathological anxiety. Using a rat model of trait anxiety generated by…”
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Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I by Landgraf, Rainer, Keßler, Melanie S., Bunck, Mirjam, Murgatroyd, Chris, Spengler, Dietmar, Zimbelmann, Marina, Nußbaumer, Markus, Czibere, Ludwig, Turck, Christoph W., Singewald, Nicolas, Rujescu, Dan, Frank, Elisabeth

“…Two animal models of trait anxiety, HAB/LAB rats and mice, are described, representing inborn extremes in anxiety-related behavior. The comprehensive…”
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Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions by Sartori, Simone B, Hauschild, Markus, Bunck, Mirjam, Gaburro, Stefano, Landgraf, Rainer, Singewald, Nicolas

“…The propensity to develop an anxiety disorder is thought to be determined by genetic and environmental factors. Here we investigated the relationship between a…”
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Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety by Kromer, Simone A, Kessler, Melanie S, Milfay, Dale, Birg, Isabel N, Bunck, Mirjam, Czibere, Ludwig, Panhuysen, Markus, Putz, Benno, Deussing, Jan M, Holsboer, Florian, Landgraf, Rainer, Turck, Christoph W

“…For >15 generations, CD1 mice have been selectively and bidirectionally bred for either high-anxiety-related behavior (HAB-M) or low-anxiety-related behavior…”
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Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies by Frank, Elisabeth, Kessler, Melanie S, Filiou, Michaela D, Zhang, Yaoyang, Maccarrone, Giuseppina, Reckow, Stefan, Bunck, Mirjam, Heumann, Hermann, Turck, Christoph W, Landgraf, Rainer, Hambsch, Boris

“…The identification of differentially regulated proteins in animal models of psychiatric diseases is essential for a comprehensive analysis of associated…”
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Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice by Czibere, Ludwig, Baur, Laura A, Wittmann, Anke, Gemmeke, Katja, Steiner, Andrea, Weber, Peter, Pütz, Benno, Ahmad, Nafees, Bunck, Mirjam, Graf, Cornelia, Widner, Regina, Kühne, Claudia, Panhuysen, Markus, Hambsch, Boris, Rieder, Gabriele, Reinheckel, Thomas, Peters, Christoph, Holsboer, Florian, Landgraf, Rainer, Deussing, Jan M

“…Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim…”
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Impaired Repression at a Vasopressin Promoter Polymorphism Underlies Overexpression of Vasopressin in a Rat Model of Trait Anxiety by Murgatroyd, Chris, Wigger, Alexandra, Frank, Elisabeth, Singewald, Nicolas, Bunck, Mirjam, Holsboer, Florian, Landgraf, Rainer, Spengler, Dietmar

“…Two inbred rat lines have been developed that show either high (HAB) or low (LAB) anxiety-related behavior. The behavioral phenotype correlates with arginine…”
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Co-segregation of hyperactivity, active coping styles, and cognitive dysfunction in mice selectively bred for low levels of anxiety by Yen, Yi-Chun, Anderzhanova, Elmira, Bunck, Mirjam, Schuller, Julia, Landgraf, Rainer, Wotjak, Carsten T

“…We established mouse models of extremes in trait anxiety, which are based on selective breeding for low vs. normal vs. high open-arm exploration on the…”
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A hypomorphic vasopressin allele prevents anxiety-related behavior by Bunck, Mirjam, Czibere, Ludwig, Horvath, Charlotte, Graf, Cornelia, Frank, Elisabeth, Kessler, Melanie S, Murgatroyd, Chris, Müller-Myhsok, Bertram, Gonik, Mariya, Weber, Peter, Pütz, Benno, Muigg, Patrik, Panhuysen, Markus, Singewald, Nicolas, Bettecken, Thomas, Deussing, Jan M, Holsboer, Florian, Spengler, Dietmar, Landgraf, Rainer

“…To investigate neurobiological correlates of trait anxiety, CD1 mice were selectively bred for extremes in anxiety-related behavior, with high (HAB) and low…”
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Protein Biomarkers in a Mouse Model of Extremes in Trait Anxiety by Ditzen, Claudia, Jastorff, Archana M., Kessler, Melanie S., Bunck, Mirjam, Teplytska, Larysa, Erhardt, Angelika, Krömer, Simone A., Varadarajulu, Jeeva, Targosz, Bianca-Sabrina, Sayan-Ayata, Eser F., Holsboer, Florian, Landgraf, Rainer, Turck, Christoph W.

“…Brain proteome analysis of mice selectively bred for either high or low anxiety-related behavior revealed quantitative and qualitative protein expression…”
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The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety by Gonik, Mariya, Frank, Elisabeth, Keßler, Melanie S, Czamara, Darina, Bunck, Mirjam, Yen, Yi-Chun, Pütz, Benno, Holsboer, Florian, Bettecken, Thomas, Landgraf, Rainer, Müller-Myhsok, Bertram, Touma, Chadi, Czibere, Ludwig

“…The hypothalamic-pituitary-adrenal (HPA) axis is essential to control physiological stress responses in mammals. Its dysfunction is related to several mental…”
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Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior by Sotnikov, Sergey, Wittmann, Anke, Bunck, Mirjam, Bauer, Sabrina, Deussing, Jan, Schmidt, Mathias, Touma, Chadi, Landgraf, Rainer, Czibere, Ludwig

“…Summary Depression and anxiety disorders are often characterized by altered hypothalamic–pituitary–adrenal (HPA) axis re-/activity. However, the presence of a…”
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Maternal care differs in mice bred for high vs. low trait anxiety: Impact of brain vasopressin and cross-fostering by Kessler, Melanie S., Bosch, Oliver J., Bunck, Mirjam, Landgraf, Rainer, Neumann, Inga D.

“…Brain arginine vasopressin (AVP) not only regulates male social behavior and emotionality, but also promotes maternal behavior, as has been shown in rats. In…”
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Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2 by Deussing, Jan M, Breu, Johannes, Kühne, Claudia, Kallnik, Magdalena, Bunck, Mirjam, Glasl, Lisa, Yen, Yi-Chun, Schmidt, Mathias V, Zurmühlen, Regine, Vogl, Annette M, Gailus-Durner, Valérie, Fuchs, Helmut, Hölter, Sabine M, Wotjak, Carsten T, Landgraf, Rainer, de Angelis, Martin Hrabé, Holsboer, Florian, Wurst, Wolfgang

“…Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and urocortin 2, the other…”
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Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety by Yen, Yi-Chun, Mauch, Christoph P., Dahlhoff, Maik, Micale, Vincenzo, Bunck, Mirjam, Sartori, Simone B., Singewald, Nicolas, Landgraf, Rainer, Wotjak, Carsten T.

“…► Mice with high trait anxiety (HAB) developed higher levels of conditioned fear. ► This was associated with changes in phosphorylation of AKT in the amygdala…”
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Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice by Keßler, Melanie S., Murgatroyd, Chris, Bunck, Mirjam, Czibere, Ludwig, Frank, Elisabeth, Jacob, Wolfgang, Horvath, Charlotte, Muigg, Patrik, Holsboer, Florian, Singewald, Nicolas, Spengler, Dietmar, Landgraf, Rainer

“…Following secretion from the posterior pituitary, the neuropeptide vasopressin (AVP) stimulates the kidney to retain water, and when released centrally it can…”
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Stable Isotope Metabolic Labeling with a Novel .sup.15N-Enriched Bacteria Diet for Improved Proteomic Analyses of Mouse Models for Psychopathologies by Frank, Elisabeth, Kessler, Melanie S, Filiou, Michaela D, Zhang, Yaoyang, Maccarrone, Giuseppina, Reckow, Stefan, Bunck, Mirjam, Heumann, Hermann, Turck, Christoph W, Landgraf, Rainer, Hambsch, Boris

“…The identification of differentially regulated proteins in animal models of psychiatric diseases is essential for a comprehensive analysis of associated…”
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