Search Results - "Bunch, Thomas"

High‐power short duration and low‐power long duration in atrial fibrillation ablation: A meta‐analysis by Kewcharoen, Jakrin, Techorueangwiwat, Chol, Kanitsoraphan, Chanavuth, Leesutipornchai, Thiratest, Akoum, Nazem, Bunch, Thomas J., Navaravong, Leenhapong

“…Background Multiple strategies have advocation for power titration and catheter movement during atrial fibrillation (AF) ablation. Comparative favoring…”
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Effects of electrical biostimulation and silver ions on porcine fibroblast cells by Zhao, Yuanfeng, Bunch, Thomas D, Isom, S Clay

“…The medical applications of electrical biostimulation and silver ions have been evaluated in laboratory experiments and clinical studies for more than two…”
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Mortality benefit with AF ablation: Impact of normal sinus rhythm seen in CABANA and EAST AFnet by Crawford, Michael, Steinberg, Benjamin A., Ranjan, Ravi, Konstantinidis, Klitos, Navaravong, Leenhapong, Bunch, Thomas J.

“…Atrial fibrillation (AF) is significantly associated with morbidity and mortality and erodes the quality and quantity of life. It is standard of care to treat…”
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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET by Kanassatega, Rhye-Samuel, Bunch, Thomas A., Lepak, Victoria C., Wang, Christopher, Colson, Brett A.

“…Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-associated protein of the sarcomere and a potential therapeutic target for treating contractile…”
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Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling by HASSOUNAH, Nadia B, BUNCH, Thomas A, MCDERMOTT, Kimberly M

“…Abnormal Hedgehog (Hh) pathway activity has been reported in many cancers, including basal cell carcinomas, medulloblastomas, rhabdomyosarcomas, glioblastomas,…”
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Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long‐term outcomes in patients with and without structural heart disease by Sessions, Andrew J., May, Heidi T., Crandall, Brian G., Day, John D., Cutler, Michael J., Groh, Christopher A., Navaravong, Leenapong, Ranjan, Ravi, Steinberg, Benjamin A., J. Bunch, Thomas

“…Introduction Atrial Fibrillation (AF) is a common arrhythmia often comorbid with systolic or diastolic heart failure (HF). Catheter ablation is a more…”
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Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity by Bunch, Thomas A.

“…Integrin αIIbβ3 affinity regulation by talin binding to the cytoplasmic tail of β3 is a generally accepted model for explaining activation of this integrin in…”
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Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system by Fan, Zhiqiang, Li, Wei, Lee, Sang R, Meng, Qinggang, Shi, Bi, Bunch, Thomas D, White, Kenneth L, Kong, Il-Keun, Wang, Zhongde

“…The golden Syrian hamster is the model of choice or the only rodent model for studying many human diseases. However, the lack of gene targeting tools in…”
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Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation by Dvornikov, Alexey V, Bunch, Thomas A, Lepak, Victoria C, Colson, Brett A

“…Cardiac muscle contraction is regulated by Ca2+-induced structural changes of the thin filaments to permit myosin cross-bridge cycling driven by ATP hydrolysis…”
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Catheter ablation for atrial fibrillation in the elderly >75 years old: Systematic review and meta‐analysis by Prasitlumkum, Narut, Tokavanich, Nithi, Trongtorsak, Angkawipa, Cheungpasitporn, Wisit, Kewcharoen, Jakrin, Chokesuwattanaskul, Ronpichai, Akoum, Nazem, Jared Bunch, Thomas, Navaravong, Leenhapong

“…Introduction Atrial fibrillation (AF) ablation is increasingly performed worldwide. As comfort with AF ablation increases, the procedure is increasingly used…”
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Comprehensive analysis of same day discharge after atrial fibrillation ablation: Clinical, cost, and patient reported outcomes by Zenger, Brian, Torre, Michael, Zhang, Yue, Boo, Leeming, Jamshidian, Farid, Young, Jeff, Bunch, Thomas J., Steinberg, Benjamin A.

“…Background Same day discharge (SDD) following atrial fibrillation (AF) ablation procedure has emerged as routine practice, and primarily driven by operator…”
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In-situ characterization of porcine fibroblasts in response to silver ions by Raman spectroscopy and liquid scanning transmission electron microscopy by Zhao, Yuanfeng, Zhang, Wei, Van Devener, Brian, Bunch, Thomas D., Zhou, Anhong, Isom, S. Clay

“…Since silver ion is known for its antimicrobial function, most of the research has focused mainly on toxicity effects rather than the role of silver ion in…”
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Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations by Wong, Fiona L, Bunch, Thomas A, Lepak, Victoria C, Steedman, Allison L, Colson, Brett A

“…N-terminal cardiac myosin-binding protein C (cMyBP-C) domains (C0-C2) bind to thick (myosin) and thin (actin) filaments to coordinate contraction and…”
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Human cardiac myosin–binding protein C restricts actin structural dynamics in a cooperative and phosphorylation-sensitive manner by Bunch, Thomas A., Kanassatega, Rhye-Samuel, Lepak, Victoria C., Colson, Brett A.

“…Cardiac myosin–binding protein C (cMyBP-C) is a thick filament-associated protein that influences actin-myosin interactions. cMyBP-C alters myofilament…”
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Economics and outcomes of sotalol in‐patient dosing approaches in patients with atrial fibrillation by Varela, Daniel L., Burnham, Tyson S., May, Heidi, Bair, Tami, Steinberg, Benjamin A., Muhlestein, Joseph, Anderson, Jeffrey, Knowlton, Kirk, Bunch, Thomas

“…Introduction There exists variability in the administration of in‐patient sotalol therapy for symptomatic atrial fibrillation (AF). The impact of this…”
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Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen by Bunch, Thomas A., Guhathakurta, Piyali, Lepak, Victoria C., Thompson, Andrew R., Kanassatega, Rhye-Samuel, Wilson, Anna, Thomas, David D., Colson, Brett A.

“…Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by…”
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Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin by Guhathakurta, Piyali, Bunch, Thomas A., Thompson, Andrew, Lepak, Victoria C., Carter, Anna L., Thomas, Jennifer J., Colson, Brett A., Thomas, David D.

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A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin by Bunch, Thomas A, Lepak, Victoria C, Bortz, Kellan M, Colson, Brett A

“…Binding properties of actin-binding proteins are typically evaluated by cosedimentation assays. However, this method is time-consuming, involves multiple…”
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Drug discovery for heart failure targeting myosin-binding protein C by Bunch, Thomas A., Guhathakurta, Piyali, Thompson, Andrew R., Lepak, Victoria C., Carter, Anna L., Thomas, Jennifer J., Thomas, David D., Colson, Brett A.

“…Cardiac MyBP-C (cMyBP-C) interacts with actin and myosin to fine-tune cardiac muscle contractility. Phosphorylation of cMyBP-C, which reduces the binding of…”
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Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer by Hassounah, Nadia B, Nunez, Martha, Fordyce, Colleen, Roe, Denise, Nagle, Ray, Bunch, Thomas, McDermott, Kimberly M

“…Primary cilia are chemosensors that play a dual role to either activate or repress Hedgehog signaling, depending on presence or absence of ligand,…”
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