Search Results - "Bume, Desta"

Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene by Yang, Mo, Carter, Sakereh, Parmar, Shaifaly, Bume, Desta D, Calabrese, David R, Liang, Xiao, Yazdani, Kamyar, Xu, Man, Liu, Zhihui, Thiele, Carol J, Schneekloth, John S

“…Abstract The MYCN gene encodes the transcription factor N-Myc, a driver of neuroblastoma (NB). Targeting G-quadruplexes (G4s) with small molecules is…”
Get full text

A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites by Balaratnam, Sumirtha, Rhodes, Curran, Bume, Desta Doro, Connelly, Colleen, Lai, Christopher C., Kelley, James A., Yazdani, Kamyar, Homan, Philip J., Incarnato, Danny, Numata, Tomoyuki, Schneekloth Jr, John S.

“…The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small…”
Get full text

Catalyzed and Promoted Aliphatic Fluorination by Bume, Desta Doro, Harry, Stefan Andrew, Lectka, Thomas, Pitts, Cody Ross

“…In the last six years, the direct functionalization of aliphatic C–H (and C–C) bonds through user-friendly, radical-based fluorination reactions has emerged as…”
Get full text

Direct, visible light-sensitized benzylic C H fluorination of peptides using dibenzosuberenone: selectivity for phenylalanine-like residues by Bume, Desta Doro, Pitts, Cody Ross, Jokhai, Rayyan Trebonias, Lectka, Thomas

“…A visible light-sensitized benzylic sp super(3) C--H fluorination protocol using dibenzosuberenone (5 mol %) and Selectfluor super( registered ) is optimized…”
Get full text

Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives by Pitts, Cody Ross, Bume, Desta Doro, Harry, Stefan Andrew, Siegler, Maxime A, Lectka, Thomas

“…In the realm of aliphatic fluorination, the problem of reactivity has been very successfully addressed in recent years. In contrast, the associated problem of…”
Get full text

Tandem C-C Bond Cleavage of ­Cyclopropanols and Oxidative Aromatization by Manganese(IV) Oxide in a Direct C-H to C-C Functionalization of Heteroaromatics by Bume, Desta Doro, Pitts, Cody Ross, Lectka, Thomas

“…We report a direct C–H to C–C bond functionalization of electron‐deficient heteroaromatics enabled by mild C–C bond cleavage of cyclopropanols as a new route…”
Get full text

Sensitized Aliphatic Fluorination Directed by Terpenoidal Enones: A “Visible Light” Approach by Bume, Desta Doro, Harry, Stefan Andrew, Pitts, Cody Ross, Lectka, Thomas

“…In our continued effort to address the challenges of selective sp3 C–H fluorination on complex molecules, we report a sensitized aliphatic fluorination…”
Get full text

Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression by Parmar, Shaifaly, Bume, Desta Doro, Connelly, Colleen M., Boer, Robert E., Prestwood, Peri R., Wang, Zhen, Labuhn, Henning, Sinnadurai, Krishshanthi, Feri, Adeline, Ouellet, Jimmy, Homan, Philip, Numata, Tomoyuki, Schneekloth, John S.

“…Riboswitches are structured RNA elements that regulate gene expression upon binding to small molecule ligands. Understanding the mechanisms by which small…”
Get full text

Unstrained C-C bond activation and directed fluorination through photocatalytically-generated radical cations by Pitts, Cody Ross, Bloom, Michelle Sheanne, Bume, Desta Doro, Zhang, Qinze Arthur, Lectka, Thomas

“…Expanding the repertoire of controlled radical fluorination techniques, we present a photosensitized unstrained C-C bond activation/directed monofluorination…”
Get full text

Ketones as directing groups in photocatalytic sp3 C-H fluorination by Bume, Desta Doro, Pitts, Cody Ross, Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N, Siegler, Maxime A, Lectka, Thomas

“…The ubiquitous ketone carbonyl group generally deactivates substrates toward radical-based fluorinations, especially sites closest to it. Herein, ketones are…”
Get full text

Site-Selective Approach to [beta]-Fluorination: Photocatalyzed Ring Opening of Cyclopropanols by Bloom, Steven, Bume, Desta Doro, Pitts, Cody Ross, Lectka, Thomas

“…To expand upon the recent pioneering reports of catalyzed sp3 CH fluorination methods, the next rational step is to focus on directing "radical-based…”
Get full text

Site-Selective Approach to β-Fluorination: Photocatalyzed Ring Opening of Cyclopropanols by Bloom, Steven, Bume, Desta Doro, Pitts, Cody Ross, Lectka, Thomas

“…To expand upon the recent pioneering reports of catalyzed sp3 CH fluorination methods, the next rational step is to focus on directing “radical‐based…”
Get full text

Fluorofunctionalization of CC Bonds with Selectfluor: Synthesis of β‑Fluoropiperazines through a Substrate-Guided Reactivity Switch by Capilato, Joseph N, Bume, Desta Doro, Lee, Wei Hao, Hoffenberg, Louis E. S, Jokhai, Rayyan Trebonias, Lectka, Thomas

“…The halofunctionalization of alkene substrates remains an essential tool for synthetic chemists. Herein, we report regioselective ammoniofluorination of…”
Get full text

Direct, visible light-sensitized benzylic CH fluorination of peptides using dibenzosuberenone: selectivity for phenylalanine-like residues by Bume, Desta Doro, Pitts, Cody Ross, Jokhai, Rayyan Trebonias, Lectka, Thomas

“…A visible light-sensitized benzylic sp3 CH fluorination protocol using dibenzosuberenone (5 mol %) and Selectfluor® is optimized for the direct…”
Get full text

Abstract P141: Preclinical characterization of LOX-24350, a highly potent and isoform-selective FGFR3 inhibitor by Ballard, Joshua A., Kercher, Timothy, Abraham, David, Brecht, Ryan, Brooks, Nathan A., Buckles, Thomas, Bume, Desta, Busha, David, Cedervall, Ernst Peder, Condroski, Kevin, Ebata, Kevin, Gharbi, Severine Isabelle, Hazlitt, Robert, Morales, Tony, Patel, Nisha, Podoll, Jessica, Urkalan, Kaveri, Villalain, Sandra Gomez, Walls, Shane, Watson, Faith, Yang, Peiyi, Brandhuber, Barbara J., Andrews, Steven W.

“…Alterations in the fibroblast growth factor receptors (FGFRs) have been identified as oncogenic drivers in many human cancers. Specifically, activating FGFR3…”
Get full text

Correction to Fluorofunctionalization of CC Bonds with Selectfluor: Synthesis of β‑Fluoropiperazines through a Substrate-Guided Reactivity Switch by Capilato, Joseph N, Bume, Desta Doro, Lee, Wei Hao, Hoffenberg, Louis E. S, Jokhai, Rayyan Trebonias, Lectka, Thomas

Get full text

Ketones as directing groups in photocatalytic sp3 C-H fluorinationElectronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02703f by Bume, Desta Doro, Pitts, Cody Ross, Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N, Siegler, Maxime A, Lectka, Thomas

“…The ubiquitous ketone carbonyl group generally deactivates substrates toward radical-based fluorinations, especially sites closest to it. Herein, ketones are…”
Get full text

Ketones as directing groups in photocatalytic sp3 C–H fluorination† †Electronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02703f by Bume, Desta Doro, Pitts, Cody Ross, Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N., Siegler, Maxime A., Lectka, Thomas

“…Visible light-sensitization allows conformationally rigid ketones to act as “directing groups” for aliphatic fluorination using Selectfluor, catalytic benzil,…”
Get full text

Ketones as directing groups in photocatalytic sp 3 C-H fluorination by Bume, Desta Doro, Pitts, Cody Ross, Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N, Siegler, Maxime A, Lectka, Thomas

“…The ubiquitous ketone carbonyl group generally deactivates substrates toward radical-based fluorinations, especially sites closest to it. Herein, ketones are…”
Get full text

Unstrained C-C bond activation and directed fluorination through photocatalytically-generated radical cationsElectronic supplementary information (ESI) available: NMR spectra and computational data. See DOI: 10.1039/c5sc01973g by Pitts, Cody Ross, Bloom, Michelle Sheanne, Bume, Desta Doro, Zhang, Qinze Arthur, Lectka, Thomas

“…Expanding the repertoire of controlled radical fluorination techniques, we present a photosensitized unstrained C-C bond activation/directed monofluorination…”
Get full text