Search Results - "Bultynck, G."

Bcl-2 proteins and calcium signaling: complexity beneath the surface by Vervliet, T, Parys, J B, Bultynck, G

“…Antiapoptotic Bcl-2-family members are well known for their ‘mitochondrial’ functions as critical neutralizers of proapoptotic Bcl-2-family members, including…”
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PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress by Verfaillie, T, Rubio, N, Garg, A D, Bultynck, G, Rizzuto, R, Decuypere, J-P, Piette, J, Linehan, C, Gupta, S, Samali, A, Agostinis, P

“…Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to…”
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Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl by Monaco, G, Decrock, E, Akl, H, Ponsaerts, R, Vervliet, T, Luyten, T, De Maeyer, M, Missiaen, L, Distelhorst, C W, De Smedt, H, Parys, J B, Leybaert, L, Bultynck, G

“…Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP 3 R) via its BH4 domain, thereby suppressing IP 3 R Ca 2+ -flux…”
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IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2 by Akl, H, Monaco, G, La Rovere, R, Welkenhuyzen, K, Kiviluoto, S, Vervliet, T, Molgó, J, Distelhorst, C W, Missiaen, L, Mikoshiba, K, Parys, J B, De Smedt, H, Bultynck, G

“…Disrupting inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R)/B-cell lymphoma 2 (Bcl-2) complexes using a cell-permeable peptide (stabilized TAT-fused IP 3…”
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A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome by Ahuja, K, Vandenabeele, M, Nami, F, Lefevere, E, Van Hoecke, J, Bergmans, S, Claes, M, Vervliet, T, Neyrinck, K, Burg, T, De Herdt, D, Bhaskar, P, Zhu, Y, Looser, Z J, Loncke, J, Gsell, W, Plaas, M, Agostinis, P, Swinnen, J V, Van Den Bosch, L, Bultynck, G, Saab, A S, Wolfs, E, Chai, Y C, Himmelreich, U, Verfaillie, C, Moons, L, De Groef, L

“…Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually…”
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Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease by Chernyuk, D., Callens, M., Polozova, M., Gordeev, A., Chigriai, M., Rakovskaya, A., Ilina, A., Pchitskaya, E., Van den Haute, C., Vervliet, T., Bultynck, G., Bezprozvanny, I.

“…Alzheimer's disease (AD) is the most common cause of dementia. An early feature of the AD pathology is the dysregulation of intracellular Ca2+ signaling in…”
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Polycystins and cellular Ca2+ signaling by Mekahli, D, Parys, Jan B, Bultynck, G, Missiaen, L, De Smedt, H

“…The cystic phenotype in autosomal dominant polycystic kidney disease is characterized by a profound dysfunction of many cellular signaling patterns, ultimately…”
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TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis by Rojas-Rivera, D, Armisén, R, Colombo, A, Martínez, G, Eguiguren, A L, Díaz, A, Kiviluoto, S, Rodríguez, D, Patron, M, Rizzuto, R, Bultynck, G, Concha, M L, Sierralta, J, Stutzin, A, Hetz, C

“…Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of…”
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BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival by Lisak, D, Schacht, T, Gawlitza, A, Albrecht, P, Aktas, O, Koop, B, Gliem, M, Hofstetter, H H, Zanger, K, Bultynck, G, Parys, J B, De Smedt, H, Kindler, T, Adams-Quack, P, Hahn, M, Waisman, A, Reed, J C, Hövelmeyer, N, Methner, A

“…The endoplasmic reticulum (ER) serves as the major intracellular Ca(2+) store and has a role in the synthesis and folding of proteins. BAX (BCL2-associated X…”
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BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival by Lisak, D, Schacht, T, Gawlitza, A, Albrecht, P, Aktas, O, Koop, B, Gliem, M, Hofstetter, H H, Zanger, K, Bultynck, G, Parys, J B, De Smedt, H, Kindler, T, Adams-Quack, P, Hahn, M, Waisman, A, Reed, J C, Hövelmeyer, N, Methner, A

“…The endoplasmic reticulum (ER) serves as the major intracellular Ca 2+ store and has a role in the synthesis and folding of proteins. BAX (BCL2-associated X…”
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Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis by Decrock, E, Krysko, D V, Vinken, M, Kaczmarek, A, Crispino, G, Bol, M, Wang, N, De Bock, M, De Vuyst, E, Naus, C C, Rogiers, V, Vandenabeele, P, Erneux, C, Mammano, F, Bultynck, G, Leybaert, L

“…Decades of research have indicated that gap junction channels contribute to the propagation of apoptosis between neighboring cells. Inositol…”
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Bax Inhibitor-1 is a novel IP3 receptor-interacting and -sensitizing protein by Kiviluoto, S, Schneider, L, Luyten, T, Vervliet, T, Missiaen, L, De Smedt, H, Parys, J B, Methner, A, Bultynck, G

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Differential Effects of Bitter Compounds on the Taste Transduction Channels TRPM5 and IP3 Receptor Type 3 by GEES, Maarten, ALPIZAR, Yeranddy A, LUYTEN, Tomas, PARYS, Jan B, NILIUS, Bernd, BULTYNCK, Geert, VOETS, Thomas, TALAVERA, Karel

“…Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a Ca(2+)-activated nonselective cation channel involved in the transduction of…”
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Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release by Mekahli, D, Sammels, E, Luyten, T, Welkenhuyzen, K, van den Heuvel, L.P, Levtchenko, E.N, Gijsbers, R, Bultynck, G, Parys, J.B, De Smedt, H, Missiaen, L

“…Abstract Autosomal dominant polycystic kidney disease is caused by loss-of-function mutations in the PKD1 or PKD2 genes encoding respectively polycystin-1 and…”
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Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor by Bultynck, G, De Smet, P, Rossi, D, Callewaert, G, Missiaen, L, Sorrentino, V, De Smedt, H, Parys, J B

“…We investigated the interaction of the 12 kDa FK506-binding protein (FKBP12) with two ryanodine-receptor isoforms (RyR1 and RyR3) and with two myo-inositol…”
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Pharmacology of inositol trisphosphate receptors by Bultynck, G, Sienaert, I, Parys, J B, Callewaert, G, De Smedt, H, Boens, N, Dehaen, W, Missiaen, L

“…In almost all cells, cytosolic Ca(2+) is a crucial intracellular messenger, regulating many cellular processes. In non-excitable as well as in some excitable…”
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Endoplasmic-reticulum calcium depletion and disease by Mekahli, Djalila, Bultynck, Geert, Parys, Jan B, De Smedt, Humbert, Missiaen, Ludwig

“…The endoplasmic reticulum (ER) as an intracellular Ca(2+) store not only sets up cytosolic Ca(2+) signals, but, among other functions, also assembles and folds…”
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HIF-1α metabolically controls collagen synthesis and modification in chondrocytes by Stegen, Steve, Laperre, Kjell, Eelen, Guy, Rinaldi, Gianmarco, Fraisl, Peter, Torrekens, Sophie, Van Looveren, Riet, Loopmans, Shauni, Bultynck, Geert, Vinckier, Stefan, Meersman, Filip, Maxwell, Patrick H., Rai, Jyoti, Weis, MaryAnn, Eyre, David R., Ghesquière, Bart, Fendt, Sarah-Maria, Carmeliet, Peter, Carmeliet, Geert

“…Endochondral ossification, an important process in vertebrate bone formation, is highly dependent on correct functioning of growth plate chondrocytes 1 …”
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Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics by Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

“…Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum…”
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Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells by Bultynck, G, De Smedt, H, Parys, J B, Callewaert, G, Missiaen, L

“…We have investigated how the immunosuppressant drug FK506 affected the basal Ca(2+) leak in permeabilized A7r5 cells. Non-mitochondrial Ca(2+) stores loaded to…”
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