Search Results - "Bultot, Laurent"

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration by Mounier, Rémi, Théret, Marine, Arnold, Ludovic, Cuvellier, Sylvain, Bultot, Laurent, Göransson, Olga, Sanz, Nieves, Ferry, Arnaud, Sakamoto, Kei, Foretz, Marc, Viollet, Benoit, Chazaud, Bénédicte

“…Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present…”
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AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation by Gélinas, Roselle, Mailleux, Florence, Dontaine, Justine, Bultot, Laurent, Demeulder, Bénédicte, Ginion, Audrey, Daskalopoulos, Evangelos P., Esfahani, Hrag, Dubois-Deruy, Emilie, Lauzier, Benjamin, Gauthier, Chantal, Olson, Aaron K., Bouchard, Bertrand, Des Rosiers, Christine, Viollet, Benoit, Sakamoto, Kei, Balligand, Jean-Luc, Vanoverschelde, Jean-Louis, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc

“…AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte…”
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AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis by Theret, Marine, Gsaier, Linda, Schaffer, Bethany, Juban, Gaëtan, Ben Larbi, Sabrina, Weiss‐Gayet, Michèle, Bultot, Laurent, Collodet, Caterina, Foretz, Marc, Desplanches, Dominique, Sanz, Pascual, Zang, Zizhao, Yang, Lin, Vial, Guillaume, Viollet, Benoit, Sakamoto, Kei, Brunet, Anne, Chazaud, Bénédicte, Mounier, Rémi

“…Control of stem cell fate to either enter terminal differentiation versus returning to quiescence (self‐renewal) is crucial for tissue repair. Here, we showed…”
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New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans by Ferté, Laura, Marino, Alice, Battault, Sylvain, Bultot, Laurent, Van Steenbergen, Anne, Bol, Anne, Cumps, Julien, Ginion, Audrey, Koepsell, Hermann, Dumoutier, Laure, Hue, Louis, Horman, Sandrine, Bertrand, Luc, Beauloye, Christophe

“…Although sodium glucose cotransporter 1 (SGLT1) has been identified as one of the major SGLT isoforms expressed in the heart, its exact role remains elusive…”
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Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662 by Ducommun, Serge, Ford, Rebecca J, Bultot, Laurent, Deak, Maria, Bertrand, Luc, Kemp, Bruce E, Steinberg, Gregory R, Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Activation of AMPK provides beneficial outcomes in…”
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Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle by Bultot, Laurent, Jensen, Thomas E, Lai, Yu-Chiang, Madsen, Agnete L B, Collodet, Caterina, Kviklyte, Samanta, Deak, Maria, Yavari, Arash, Foretz, Marc, Ghaffari, Sahar, Bellahcene, Mohamed, Ashrafian, Houman, Rider, Mark H, Richter, Erik A, Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) plays diverse roles and coordinates complex metabolic pathways for maintenance of energy homeostasis. This could be…”
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The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart by Dontaine, Justine, Bouali, Asma, Daussin, Frederic, Bultot, Laurent, Vertommen, Didier, Martin, Manon, Rathagirishnan, Raahulan, Cuillerier, Alexanne, Horman, Sandrine, Beauloye, Christophe, Gatto, Laurent, Lauzier, Benjamin, Bertrand, Luc, Burelle, Yan

“…Protein O-GlcNAcylation is increasingly recognized as an important cellular regulatory mechanism, in multiple organs including the heart. However, the…”
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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli by Novellasdemunt, Laura, Bultot, Laurent, Manzano, Anna, Ventura, Francesc, Rosa, Jose Luis, Vertommen, Didier, Rider, Mark H, Navarro-Sabate, Àurea, Bartrons, Ramon

“…PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose 2,6-bisphosphate), a key…”
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AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes by Gélinas, Roselle, Dontaine, Justine, Horman, Sandrine, Beauloye, Christophe, Bultot, Laurent, Bertrand, Luc

“…The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. Its activation under energetic stress is known to activate energy-producing…”
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An O -GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat by Denis, Manon, Dupas, Thomas, Persello, Antoine, Dontaine, Justine, Bultot, Laurent, Betus, Charlotte, Pelé, Thomas, Dhot, Justine, Erraud, Angélique, Maillard, Anaïs, Montnach, Jérôme, Leroux, Aurélia A, Bigot-Corbel, Edith, Vertommen, Didier, Rivière, Matthieu, Lebreton, Jacques, Tessier, Arnaud, Waard, Michel De, Bertrand, Luc, Rozec, Bertrand, Lauzier, Benjamin

“…Sepsis in the young population, which is particularly at risk, is rarely studied. -GlcNAcylation is a post-translational modification involved in cell…”
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AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase by Bultot, Laurent, Guigas, Bruno, Von Wilamowitz-Moellendorff, Alexander, Maisin, Liliane, Vertommen, Didier, Hussain, Nusrat, Beullens, Monique, Guinovart, Joan J, Foretz, Marc, Viollet, Benoît, Sakamoto, Kei, Hue, Louis, Rider, Mark H

“…Recombinant muscle GYS1 (glycogen synthase 1) and recombinant liver GYS2 were phosphorylated by recombinant AMPK (AMP-activated protein kinase) in a…”
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The Regulation of Insulin-Stimulated Cardiac Glucose Transport via Protein Acetylation by Renguet, Edith, Bultot, Laurent, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc

“…Cellular catabolism is the cell capacity to generate energy from various substrates to sustain its function. To optimize this energy production, cells are able…”
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Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes by Peugnet, Victoriane, Chwastyniak, Maggy, Mulder, Paul, Lancel, Steve, Bultot, Laurent, Fourny, Natacha, Renguet, Edith, Bugger, Heiko, Beseme, Olivia, Loyens, Anne, Heyse, Wilfried, Richard, Vincent, Amouyel, Philippe, Bertrand, Luc, Pinet, Florence, Dubois-Deruy, Emilie

“…Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen…”
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The Salt-Inducible Kinases: Emerging Metabolic Regulators by Sakamoto, Kei, Bultot, Laurent, Göransson, Olga

“…The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that…”
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Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK by Hunter, Roger W., Foretz, Marc, Bultot, Laurent, Fullerton, Morgan D., Deak, Maria, Ross, Fiona A., Hawley, Simon A., Shpiro, Natalia, Viollet, Benoit, Barron, Denis, Kemp, Bruce E., Steinberg, Gregory R., Hardie, D. Grahame, Sakamoto, Kei

“…AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a…”
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AMPK alpha 1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration by Mounier, Remi, Theret, Marine, Arnold, Ludovic, Cuvellier, Sylvain, Bultot, Laurent, Goransson, Olga, Sanz, Nieves, Ferry, Arnaud, Sakamoto, Kei, etz, Marc, Viollet, Benoit, Chazaud, Benedicte

“…Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present…”
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Medium‐chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte‐neuron lactate and ketone body shuttle systems by Thevenet, Jonathan, De Marchi, Umberto, Domingo, Jaime Santo, Christinat, Nicolas, Bultot, Laurent, Lefebvre, Gregory, Sakamoto, Kei, Descombes, Patrick, Masoodi, Mojgan, Wiederkehr, Andreas

“…Medium‐chain triglycerides have been used as part of a ketogenic diet effective in reducing epileptic episodes. The health benefits of the derived medium‐chain…”
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Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport by De Loof, Marine, Renguet, Edith, Ginion, Audrey, Bouzin, Caroline, Horman, Sandrine, Beauloye, Christophe, Bertrand, Luc, Bultot, Laurent

“…Fatty acids (FAs) rapidly and efficiently reduce cardiac glucose uptake in the Randle cycle or glucose-FA cycle. This fine-tuned physiological regulation is…”
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Metformin improves infarct size in mice exposed to chronic intermittent hypoxia, a major feature of obstructive sleep apnea by Belaidi, Elise, Moulin, Sophie, Thomas, Amandine, Dontaine, Justine, Bultot, Laurent, Arnaud, Claire, Guigas, Bruno, Bertrand, Luc

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The metabolic overfueling-mediated protein acetylation greatly participates in the inhibition of cardiac glucose uptake by fatty acids by Bultot, Laurent, De Loof, Marine, Renguet, Edith, Ginion, Audrey, Horman, Sandrine, Beauloye, Christophe, Bertrand, Luc

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