Search Results - "Bullough, Jeremy"

Pharmacologic activation of PKM2 slows lung tumor xenograft growth by Parnell, K Mark, Foulks, Jason M, Nix, Rebecca N, Clifford, Adrianne, Bullough, Jeremy, Luo, Bai, Senina, Anna, Vollmer, David, Liu, Jihua, McCarthy, Virgil, Xu, Yong, Saunders, Michael, Liu, Xiao-Hui, Pearce, Scott, Wright, Kevin, O'Reilly, Marc, McCullar, Michael V, Ho, Koc-Kan, Kanner, Steven B

“…Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may…”
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Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2) by Xu, Yong, Liu, Xiao-Hui, Saunders, Michael, Pearce, Scott, Foulks, Jason M., Parnell, K. Mark, Clifford, Adrianne, Nix, Rebecca N., Bullough, Jeremy, Hendrickson, Thomas F., Wright, Kevin, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan

“…Activators of the pyruvate kinase M2 (PKM2) are currently attracting significant interest as potential anticancer therapies. They may achieve a novel…”
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Abstract B143: PKM2 metabolic activator slows lung cancer xenograft growth by Parnell, K. Mark, Foulks, Jason M., Clifford, Adrianne, Bullough, Jeremy, Luo, Bai, Vollmer, David, Liu, Jihua, McCarthy, Virgil, Shaffer, Matthew, Senina, Anna, Liu, Xiao-Hui, Pearce, Scott, Xu, Yong, Saunders, Michael, Ho, Kan, McCullar, Michael V., Kanner, Steven B.

“…Tumor cells primarily utilize aerobic glycolysis, rather than oxidative phosphorylation, to metabolize glucose (the Warburg effect). The M2 splice form of…”
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