Search Results - "Bullock, Peter L."

Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes by LeCluyse, Edward L., Bullock, Peter L., Parkinson, Andrew

“…The use of in vitro and in vivo systems to evaluate hepatic drug uptake and metabolism, microsomal cytochrome P450 induction, drug interactions,…”
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Development and characterization of an open tubular column containing immobilized P-glycoprotein for rapid on-line screening for P-glycoprotein substrates by Moaddel, Ruin, Bullock, Peter L, Wainer, Irving W

“…Cellular membranes from a cell line expressing P-glycoprotein (Pgp(+)) and from a cell line that does not express Pgp (Pgp(−)) were immobilized on the surface…”
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Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability by Moaddel, Ruin, Hamid, Rachid, Patel, Sharvil, Bullock, Peter L., Wainer, Irving W.

“…The Caco-2 cell monolayer model was used to classify 13 compounds as P-glycoprotein ( Pgp) substrates or non-substrates. The apparent permeability coefficients…”
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Effects of Freezing, Thawing, and Storing Human Liver Microsomes on Cytochrome P450 Activity by Pearce, Robin E., McIntyre, Christin J., Madan, Ajay, Sanzgiri, Uma, Draper, Alison J., Bullock, Peter L., Cook, Dorn C., Burton, L.Alayne, Latham, Jason, Nevins, Cheryl, Parkinson, Andrew

“…The stability of cytochrome P450 enzymes, cytochrome b5, and NADPH–cytochrome c reductase was examined in (A) human liver samples frozen in liquid nitrogen and…”
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Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes by GUNS, Emma S, BULLOCK, Peter L, REIMER, Mark L. J, DIXON, Ross, BALLY, Marcel, MAYER, Lawrence D

“…The novel substituted imidazole compound, OC144-093 exhibits potent biological activity in vitro and in vivo for reversal of P-glycoprotein (PgP) based…”
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Detection of cytochrome P4501A in several species using antibody against a synthetic peptide derived from rainbow trout cytochrome P4501A1 by Lin, Song, Bullock, Peter L., Addison, Richard F., Bandiera, Stelvio M.

“…Induction of cytochrome P4501A (CYP1A) is being used increasingly as a biomarker to indicate exposure of organisms to environmental contaminants such as some…”
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Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column : Comparison of chromatographic results with Caco-2 permeability: Immobilization and Applications of Functional Proteins, Nucleic Acids and Cells at Solid Interface by MOADDEL, Ruin, HAMID, Rachid, PATEL, Sharvil, BULLOCK, Peter L, WAINER, Irving W

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Cultured rat hepatocytes by LeCluyse, E L, Bullock, P L, Parkinson, A, Hochman, J H

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