Search Results - "Bullock, MR"

A Double-Blind, Placebo-Controlled Study of the Safety, Tolerability and Pharmacokinetics of CP-101,606 in Patients with a Mild or Moderate Traumatic Brain Injury by MERCHANT, RANDALL E., BULLOCK, M. ROSS, CARMACK, CYNTHIA A., SHAH, AJIT K., WILNER, KEITH D., KO, GRANT, WILLIAMS, STEPHEN A.

“…CP‐101,606 is a postsynaptic antagonist of the glutamate‐mediated NR2B subunit of the N‐methyl‐d‐aspartate (NMDA) receptor. When administered intravenously…”
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An Open-Label Study of CP-101,606 in Subjects with a Severe Traumatic Head Injury or Spontaneous Intracerebral Hemorrhage by BULLOCK, M. ROSS, MERCHANT, RANDALL E., CARMACK, CYNTHIA A., DOPPENBERG, EGON, SHAH, AJIT K., WILNER, KEITH D., KO, GRANT, WILLIAMS, STEPHEN A.

“…CP‐101,606 is a postsynaptic antagonist of N‐methyl‐d‐aspartate (NMDA) receptors bearing the NR2B subunit. When administered intravenously (i.v.), it decreases…”
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Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries by MARMAROU, Anthony, SIGNORETTI, Stefano, FATOUROS, Panos P, PORTELLA, Gina, AYGOK, Gunes A, BULLOCK, M. Ross

“…The edema associated with brain swelling after traumatic brain injury (TBI) has been thought to be vasogenic in origin, but the results of previous laboratory…”
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Normobaric hyperoxia-induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study by TOLIAS, Christos M, REINERT, Michael, SEILER, Rolf, GILMAN, Charlotte, SCHARF, Alexander, BULLOCK, M. Ross

“…The effect of normobaric hyperoxia (fraction of inspired O2 [FIO2] concentration 100%) in the treatment of patients with traumatic brain injury (TBI) remains…”
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Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury by Kleindienst, Andrea, McGinn, Melissa J, Harvey, Harlan B, Colello, Raymond J, Hamm, Robert J, Bullock, M Ross

“…Evidence of injury-induced neurogenesis in the adult hippocampus suggests that an endogenous repair mechanism exists for cognitive dysfunction following…”
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Brain oxygenation and energy metabolism: part I-biological function and pathophysiology by Zauner, Alois, Daugherty, Wilson P, Bullock, M Ross, Warner, David S

“…CONTINUOUS OXYGEN DELIVERY and CO(2) clearance are paramount in the maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic…”
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Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system by Chirumamilla, S, Sun, D, Bullock, M R, Colello, R J

“…Recent studies indicate the existence of progenitor cells and their potential for neurogenesis in the subventricular zone (SVZ) and the hippocampus of the…”
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Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury by Rice, A.C, Khaldi, A, Harvey, H.B, Salman, N.J, White, F, Fillmore, H, Bullock, M.R

“…Recent studies have identified endogenous neural stem cells in adult rodent brains. The present study characterizes the early response of mitotically active…”
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Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats by DAUGHERTY, Wilson P, LEVASSEUR, Joseph E, DONG SUN, ROCKSWOLD, Gaylan L, BULLOCK, M. Ross

“…In the current study, the authors examined the effects of hyperbaric O2 (HBO) following fluid-percussion brain injury and its implications on brain tissue…”
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Cell proliferation and neuronal differentiation in the dentate gyrus in juvenile and adult rats following traumatic brain injury by Sun, Dong, Colello, Raymond J, Daugherty, Wilson P, Kwon, Taek H, McGinn, Melissa J, Harvey, H Ben, Bullock, M Ross

“…It is well known that the cognitive functions of juveniles recover to a greater extent than adult patients following traumatic brain injury (TBI). The exact…”
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Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies by Bullock, M R, Lyeth, B G, Muizelaar, J P

“…Laboratory studies have identified numerous potential therapeutic interventions that might have clinical application for the treatment of human traumatic brain…”
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Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats by Alessandri, Beat, Rice, Ann C, Levasseur, Joseph, DeFord, Michelle, Hamm, Robert J, Bullock, M Ross

“…Traumatic brain injury (TBI) triggers a complex pathophysiological cascade, leading to cell death. A major factor in the pathogenesis of TBI is neuronal…”
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Cerebral acid-base homeostasis after severe traumatic brain injury by CLAUSEN, Tobias, KHALDI, Ahmad, ZAUNER, Alois, REINERT, Michael, DOPPENBERG, Egon, MENZEL, Matthias, SOUKUP, Jens, ALVES, Oscar Luis, BULLOCK, M. Ross

“…Brain tissue acidosis is known to mediate neuronal death. Therefore the authors measured the main parameters of cerebral acid-base homeostasis, as well as…”
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Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients by MARMAROU, A, FATOUROS, P. P, BULLOCK, M. R, YOUNG, H. F, BARZO, P, PORTELLA, G, YOSHIHARA, M, TSUJI, O, YAMAMOTO, T, LAINE, F, SIGNORETTI, S, WARD, J. D

“…The pathogenesis of traumatic brain swelling remains unclear. The generally held view is that brain swelling is caused primarily by vascular engorgement and…”
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Lactate administration attenuates cognitive deficits following traumatic brain injury by Rice, Ann C, Zsoldos, Robert, Chen, Tao, Wilson, Margaret S, Alessandri, B, Hamm, Robert J, Ross Bullock, M

“…Moderately head injured patients often suffer long term neurological sequelae. There is no therapy for brain trauma and current treatments aim only to minimize…”
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Neurogenic fever after traumatic brain injury: an epidemiological study by Thompson, H J, Pinto-Martin, J, Bullock, M R

“…Objectives: To determine the incidence of neurogenic fever (NF) in a population of patients in the acute phase following severe traumatic brain injury (TBI);…”
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Isolation of neuronal progenitor cells from the adult human neocortex by Richardson, R M, Holloway, K L, Bullock, M R, Broaddus, W C, Fillmore, H L

“…The reliability of harvesting neuronal progenitor cells (NPCs) from the adult human neocortex has not been established, with respect to preparing autologous…”
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Guidelines for the management of severe head injury. Introduction

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Chronic ethanol consumption transiently reduces adult neural progenitor cell proliferation by Rice, Ann C., Bullock, M.Ross, Shelton, Keith L.

“…Adult neural stem/progenitor cells proliferate throughout the life of the animal in the subependymal zone and the subgranular zone of the dentate gyrus (DG)…”
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Hyperoxia: good or bad? by Bullock, M Ross

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