Search Results - "Bulloch, Michaela S"
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Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential
Published in mSphere (24-08-2023)“…Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its…”
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Is the AT-rich DNA of malaria parasites a drug target?
Published in Trends in pharmacological sciences (Regular ed.) (01-04-2022)“…A recent antimalarial screen by Alder and colleagues has uncovered a natural product, PDE-I2, with DNA-binding and schizonticidal activity against Plasmodium…”
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Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum
Published in PLoS pathogens (06-09-2024)“…Glycophosphatidylinositol (GPI) anchors are the predominant glycoconjugate in Plasmodium parasites, enabling modified proteins to associate with biological…”
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Journal Article