Search Results - "Bulloch, Esther M. M."

Poly-γ-glutamylation of biomolecules by Bashiri, Ghader, Bulloch, Esther M. M., Bramley, William R., Davidson, Madison, Stuteley, Stephanie M., Young, Paul G., Harris, Paul W. R., Naqvi, Muhammad S. H., Middleditch, Martin J., Schmitz, Michael, Chang, Wei-Chen, Baker, Edward N., Squire, Christopher J.

“…Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F 420 . Despite decades of…”
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Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis by Chi, Gamma, Manos-Turvey, Alexandra, O’Connor, Patrick D, Johnston, Jodie M, Evans, Genevieve L, Baker, Edward N, Payne, Richard J, Lott, J. Shaun, Bulloch, Esther M. M

“…MbtI is the salicylate synthase that catalyzes the first committed step in the synthesis of the iron chelating compound mycobactin in Mycobacterium…”
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The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition by Castell, Alina, Short, Francesca L, Evans, Genevieve L, Cookson, Tammie V. M, Bulloch, Esther M. M, Joseph, Dmitri D. A, Lee, Clare E, Parker, Emily J, Baker, Edward N, Lott, J. Shaun

“…Anthranilate phosphoribosyltransferase (AnPRT, EC 2.4.2.18) is a homodimeric enzyme that catalyzes the reaction between 5′-phosphoribosyl 1′-pyrophosphate…”
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Protein domain definition should allow for conditional disorder by Yegambaram, Kavestri, Bulloch, Esther M.M., Kingston, Richard L.

“…: Proteins are often classified in a binary fashion as either structured or disordered. However this approach has several deficits. Firstly, protein folding is…”
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Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis by Cookson, Tammie V M, Castell, Alina, Bulloch, Esther M M, Evans, Genevieve L, Short, Francesca L, Baker, Edward N, Lott, J Shaun, Parker, Emily J

“…AnPRT (anthranilate phosphoribosyltransferase), required for the biosynthesis of tryptophan, is essential for the virulence of Mycobacterium tuberculosis…”
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Transient Dimerization of Human MxA Promotes GTP Hydrolysis, Resulting in a Mechanical Power Stroke by Rennie, Martin L., McKelvie, Siri A., Bulloch, Esther M.M., Kingston, Richard L.

“…Myxovirus resistance (Mx) proteins restrict replication of numerous viruses. They are closely related to membrane-remodeling fission GTPases, such as dynamin…”
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Identification of Histone Demethylases in Saccharomyces cerevisiae by Tu, Shengjiang, Bulloch, Esther M.M., Yang, Lanhao, Ren, Chen, Huang, Wei-Chieh, Hsu, Pang-Hung, Chen, Chein-Hung, Liao, Chung-Lin, Yu, Hui-Ming, Lo, Wan-Sheng, Freitas, Michael A., Tsai, Ming-Daw

“…Based on the prediction that histone lysine demethylases may contain the JmjC domain, we examined the methylation patterns of five knock-out strains (ecm5Δ,…”
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Structural Analysis of the Menangle Virus P Protein Reveals a Soft Boundary between Ordered and Disordered Regions by Webby, Melissa N, Herr, Nicole, Bulloch, Esther M M, Schmitz, Michael, Keown, Jeremy R, Goldstone, David C, Kingston, Richard L

“…The paramyxoviral phosphoprotein (P protein) is the non-catalytic subunit of the viral RNA polymerase, and coordinates many of the molecular interactions…”
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Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms by Jirgis, Ehab N.M., Bashiri, Ghader, Bulloch, Esther M.M., Johnston, Jodie M., Baker, Edward N.

“…Menaquinone (MQ) is an essential component of the respiratory chains of many pathogenic organisms, including Mycobacterium tuberculosis (Mtb). The first…”
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Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI) by Manos-Turvey, Alexandra, Bulloch, Esther M. M., Rutledge, Peter J., Baker, Edward N., Lott, J. Shaun, Payne, Richard J.

“…Mycobacterium tuberculosis salicylate synthase (MbtI), a member of the chorismate‐utilizing enzyme family, catalyses the first committed step in the…”
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Removal of the C-Terminal Regulatory Domain of α-Isopropylmalate Synthase Disrupts Functional Substrate Binding by Huisman, Frances H. A, Koon, Nayden, Bulloch, Esther M. M, Baker, Heather M, Baker, Edward N, Squire, Christopher J, Parker, Emily J

“…α-Isopropylmalate synthase (α-IPMS) catalyzes the metal-dependent aldol reaction between α-ketoisovalerate (α-KIV) and acetyl-coenzyme A (AcCoA) to give…”
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Structure and function of GlmU from Mycobacterium tuberculosis by Zhang, Zhening, Bulloch, Esther M. M., Bunker, Richard D., Baker, Edward N., Squire, Christopher J.

“…Antibiotic resistance is a major issue in the treatment of infectious diseases such as tuberculosis. Existing antibiotics target only a few cellular pathways…”
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Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis by Evans, Genevieve L., Gamage, Swarna A., Bulloch, Esther M. M., Baker, Edward N., Denny, William A., Lott, J. Shaun

“…The emergence of extensively drug‐resistant strains of Mycobacterium tuberculosis (Mtb) highlights the need for new therapeutics to treat tuberculosis. We are…”
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A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket by Chai, Ai-Fen, Bulloch, Esther M. M., Evans, Genevieve L., Lott, J. Shaun, Baker, Edward N., Johnston, Jodie M.

“…Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Access to iron in host macrophages depends on iron‐chelating siderophores called…”
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Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation by Johnston, Jodie M, Bulloch, Esther MM

“…•Menaquinones (MKs) are involved in bacterial electron transport and adaptation.•The Men pathway is the most predominant of two bacterial pathways to make…”
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Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy by Yang, Lanhao, Tu, Shengjiang, Ren, Chen, Bulloch, Esther M.M., Liao, Chung-Lin, Tsai, Ming-Daw, Freitas, Michael A.

“…Methylation and acetylation of lysines are crucial posttranslational modifications that regulate gene transcription and have been shown to be misregulated in…”
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Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site by Manos-Turvey, Alexandra, Cergol, Katie M, Salam, Noeris K, Bulloch, Esther M M, Chi, Gamma, Pang, Angel, Britton, Warwick J, West, Nicholas P, Baker, Edward N, Lott, J Shaun, Payne, Richard J

“…Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the biosynthesis of mycobactin T, an iron-chelating siderophore…”
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Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway by Stanborough, Tamsyn, Ho, Ngoc Anh Thu, Bulloch, Esther M M, Bashiri, Ghader, Dawes, Stephanie S, Akazong, Etheline W, Titterington, James, Allison, Timothy M, Jiao, Wanting, Johnston, Jodie M

“…Menaquinones (MKs) are electron carriers in bacterial respiratory chains. In ( ), MKs are essential for aerobic and anaerobic respiration. As MKs are…”
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Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis by Bashiri, Ghader, Nigon, Laura V., Jirgis, Ehab N.M., Ho, Ngoc Anh Thu, Stanborough, Tamsyn, Dawes, Stephanie S., Baker, Edward N., Bulloch, Esther M.M., Johnston, Jodie M.

“…Menaquinone (vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including the human pathogen Mycobacterium…”
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Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex by Bashiri, Ghader, Johnston, Jodie M., Evans, Genevieve L., Bulloch, Esther M. M., Goldstone, David C., Jirgis, Ehab N. M., Kleinboelting, Silke, Castell, Alina, Ramsay, Rochelle J., Manos-Turvey, Alexandra, Payne, Richard J., Lott, J. Shaun, Baker, Edward N.

“…The tryptophan‐biosynthesis pathway is essential for Mycobacterium tuberculosis (Mtb) to cause disease, but not all of the enzymes that catalyse this pathway…”
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