Search Results - "Bull, Shelley B"

Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer by Ponzo, Marisa G, Lesurf, Robert, Petkiewicz, Stephanie, O'Malley, Frances P, Pinnaduwage, Dushanthi, Andrulis, Irene L, Bull, Shelley B, Chughtai, Naila, Zuo, Dongmei, Souleimanova, Margarita, Germain, David, Omeroglu, Atilla, Cardiff, Robert D, Hallett, Michael, Park, Morag

“…Elevated MET receptor tyrosine kinase correlates with poor outcome in breast cancer, yet the reasons for this are poorly understood. We thus generated a…”
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Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes by PEZZOLESI, Marcus G, POZNIK, G. David, WAGGOTT, Daryl, MERCHANT, Michael L, KROLEWSKI, Bozena, MIREA, Lucia, WANIC, Krzysztof, KATAVETIN, Pisut, KURE, Masahiko, WOLKOW, Pawel, DUNN, Jonathon S, SMILES, Adam, MYCHALECKYJ, Josyf C, WALKER, William H, BORIGHT, Andrew P, BULL, Shelley B, DORIA, Alessandro, ROGUS, John J, RICH, Stephen S, WARRAM, James H, KROLEWSKI, Andrzej S, PATERSON, Andrew D, BARATI, Michelle T, KLEIN, Jon B, NG, Daniel P. K, PLACHA, Grzegorz, CANANI, Luis H, BOCHENSKI, Jacek

“…Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes Marcus G. Pezzolesi 1 , G. David Poznik 1 , Josyf C. Mychaleckyj…”
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Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation by Wunder, Jay S., Lee, Minji J., Nam, Junghyun, Lau, Beatrice Y., Dickson, Brendan C., Pinnaduwage, Dushanthi, Bull, Shelley B., Ferguson, Peter C., Seto, Andrew, Gokgoz, Nalan, Andrulis, Irene L.

“…Immune checkpoint proteins, such as PD-L1 and PD-1, are important in several cancers; however, their role in osteosarcoma (OSA) and soft tissue sarcoma (STS)…”
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Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival by Lee, Minji, Tayyari, Farnoosh, Pinnaduwage, Dushanthi, Bayani, Jane, Bartlett, John M S, Mulligan, Anna Marie, Bull, Shelley B, Andrulis, Irene L

“…We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological…”
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Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification by Faye, Laura L, Machiela, Mitchell J, Kraft, Peter, Bull, Shelley B, Sun, Lei

“…Next generation sequencing has dramatically increased our ability to localize disease-causing variants by providing base-pair level information at costs…”
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Insights From Mixture Cure Modeling of Molecular Markers for Prognosis in Breast Cancer by YILMAZ, Yildiz E, LAWLESS, Jerald F, ANDRULIS, Irene L, BULL, Shelley B

“…With the ultimate aim of improving clinical management of breast cancer, investigators have sought to identify molecular genetic markers that stratify newly…”
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A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose by PATERSON, Andrew D, WAGGOTT, Daryl, BELOW, Jennifer E, NICOLAE, Dan, COX, Nancy J, CANTY, Angelo J, LEI SUN, BULL, Shelley B, BORIGHT, Andrew P, MOHSEN HOSSEINI, S, ENQING SHEN, SYLVESTRE, Marie-Pierre, WONG, Isidro, BHARAJ, Bhupinder, CLEARY, Patricia A, LACHIN, John M

“…A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose Andrew D. Paterson…”
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Statistical power in COVID-19 case-control host genomic study design by Lin, Yu-Chung, Brooks, Jennifer D, Bull, Shelley B, Gagnon, France, Greenwood, Celia M T, Hung, Rayjean J, Lawless, Jerald, Paterson, Andrew D, Sun, Lei, Strug, Lisa J

“…The identification of genetic variation that directly impacts infection susceptibility to SARS-CoV-2 and disease severity of COVID-19 is an important step…”
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Penalized maximum likelihood inference under the mixture cure model in sparse data by Xu, Changchang, Bull, Shelley B.

“…Introduction When a study sample includes a large proportion of long‐term survivors, mixture cure (MC) models that separately assess biomarker associations…”
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Integrating epigenetic, genetic, and phenotypic data to uncover gene-region associations with triglycerides in the GOLDN study by Romanescu, Razvan G, Espin-Garcia, Osvaldo, Ma, Jin, Bull, Shelley B

“…There has been significant interest in investigating genome-wide and epigenome-wide associations with lipids. Testing at the gene or region level may improve…”
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Prognostic Effect of Basal-Like Breast Cancers Is Time Dependent: Evidence from Tissue Microarray Studies on a Lymph Node–Negative Cohort by MULLIGAN, Anna Marie, PINNADUWAGE, Dushanthi, BULL, Shelley B, O'MALLEY, Frances P, ANDRULIS, Irene L

“…Purpose: To determine whether data obtained from tissue microarrays (TMA) of a prospectively accrued node-negative breast cancer cohort are prognostically…”
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Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors by Bane, Anita L, Pinnaduwage, Dushanthi, Colby, Sarah, Bull, Shelley B, O'Malley, Frances P, Andrulis, Irene L

“…Background BRCA1- and BRCA2-associated tumors appear to have distinct molecular signatures. BRCA1-associated tumors are predominantly basal-like cancers,…”
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A 2-step strategy for detecting pleiotropic effects on multiple longitudinal traits by Wang, Weiqiang, Feng, Zeny, Bull, Shelley B, Wang, Zuoheng

“…Genetic pleiotropy refers to the situation in which a single gene influences multiple traits and so it is considered as a major factor that underlies genetic…”
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Gene-based multiple regression association testing for combined examination of common and low frequency variants in quantitative trait analysis by Yoo, Yun Joo, Sun, Lei, Bull, Shelley B

“…Multi-marker methods for genetic association analysis can be performed for common and low frequency SNPs to improve power. Regression models are an intuitive…”
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TP53 Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study by WUNDER, Jay S, GOKGOZ, Nalan, MALKIN, David, MANGHAM, D. C, ROCK, Michael J, BELL, Robert S, ANDRULIS, Irene L, PARKES, Robert, BULL, Shelley B, ESKANDARIAN, Sasha, DAVIS, Aileen M, BEAUCHAMP, Chris P, CONRAD, Ernest U, GRIMER, Robert J, HEALEY, John H

“…Mutations of the TP53 gene have been associated with resistance to chemotherapy as well as poor prognosis in many different malignancies. This is the first…”
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CK8/18 expression, the basal phenotype, and family history in identifying BRCA1‐associated breast cancer in the Ontario site of the Breast Cancer Family Registry by Mulligan, Anna Marie, Pinnaduwage, Dushanthi, Bane, Anita L., Bull, Shelley B., O'Malley, Frances P., Andrulis, Irene L.

“…BACKGROUND. BRCA1‐associated breast cancer had been shown to be morphologically and genetically distinct from sporadic cancers. The aim of this study was to…”
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gpart: human genome partitioning and visualization of high-density SNP data by identifying haplotype blocks by Kim, Sun Ah, Brossard, Myriam, Roshandel, Delnaz, Paterson, Andrew D, Bull, Shelley B, Yoo, Yun Joo

“…Abstract Summary For the analysis of high-throughput genomic data produced by next-generation sequencing (NGS) technologies, researchers need to identify…”
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Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression by Brossard, Myriam, Paterson, Andrew D, Espin-Garcia, Osvaldo, Craiu, Radu V, Bull, Shelley B

“…Abstract When quantitative longitudinal traits are risk factors for disease progression and subject to random biological variation, joint model analysis of…”
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Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis by Eder, Lihi, Chandran, Vinod, Pellet, Fawnda, Shanmugarajah, Sutha, Rosen, Cheryl F, Bull, Shelley B, Gladman, Dafna D

“…Aim Genes that differentiate patients with psoriatic arthritis (PsA) from those with cutaneous psoriasis (PsC) may serve as markers for the development of PsA…”
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A new haplotype block detection method for dense genome sequencing data based on interval graph modeling of clusters of highly correlated SNPs by Kim, Sun Ah, Cho, Chang-Sung, Kim, Suh-Ryung, Bull, Shelley B, Yoo, Yun Joo

“…Abstract Motivation Linkage disequilibrium (LD) block construction is required for research in population genetics and genetic epidemiology, including…”
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