Search Results - "Bull, Richard J."

Occurrence and formation of chloro- and bromo-benzoquinones during drinking water disinfection by Zhao, Yuli, Anichina, Janna, Lu, Xiufen, Bull, Richard J., Krasner, Stuart W., Hrudey, Steve E., Li, Xing-Fang

“…Consumption of chlorinated drinking water has shown somewhat consistent association with increased risk of bladder cancer in a series of epidemiological…”
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Potential carcinogenic hazards of non-regulated disinfection by-products: Haloquinones, halo-cyclopentene and cyclohexene derivatives, N -halamines, halonitriles, and heterocyclic amines by Bull, Richard J, Reckhow, David A, Li, Xingfang, Humpage, Andrew R, Joll, Cynthia, Hrudey, Steve E

“…Abstract Drinking water disinfectants react with natural organic material (NOM) present in source waters used for drinking water to produce a wide variety of…”
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Nongenotoxic mechanisms involved in bromate-induced cancer in rats by Bull, Richard J., Cotruvo, Joseph A.

“…Risk assessments for bromate (BrO3 −) in drinking water are based on linear extrapolation from the total incidence of tumors in male rats. The only genotoxic…”
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Cellular and molecular mechanisms of bromate-induced cytotoxicity in human and rat kidney cells by Zhang, Xiaoling, De Silva, Dilhara, Sun, Bin, Fisher, Jeffery, Bull, Richard J, Cotruvo, Joseph. A, Cummings, Brian. S

“…Abstract The mechanisms of bromate (BrO3− )-induced toxicity in Normal Rat Kidney (NRK) and human embryonic kidney 293 (HEK293) cells were investigated. BrO3−…”
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Drinking Water as a Proportion of Total Human Exposure to Volatile N-Nitrosamines by Hrudey, Steve E., Bull, Richard J., Cotruvo, Joseph A., Paoli, Greg, Wilson, Margaret

“…Some volatile N‐nitrosamines, primarily N‐nitrosodimethylamine (NDMA), are recognized as products of drinking water treatment at ng/L levels and as known…”
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Development of a rat and human PBPK model for bromate and estimation of human equivalent concentrations in drinking water by Campbell, Jerry L., Bull, Richard J., Clewell, Harvey J.

“…A physiologically based pharmacokinetic (PBPK) model was developed to described uptake, disposition and clearance of bromate in the rat using published…”
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Therapeutic dose as the point of departure in assessing potential health hazards from drugs in drinking water and recycled municipal wastewater by Bull, Richard J., Crook, James, Whittaker, Margaret, Cotruvo, Joseph A.

“…The detection of drugs in drinking water sources has raised questions related to safety. In the absence of regulatory or other official guidance, water…”
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Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors by Kulagowski, Janusz J, Blair, Wade, Bull, Richard J, Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K, Hewitt, Peter R, Liimatta, Marya, Hurley, Christopher A, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Bir Kohli, Pawan, Maxey, Robert J, Mendonca, Rohan, Mortara, Kyle, Murray, Jeremy, Narukulla, Raman, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Waszkowycz, Bohdan, Zak, Mark

“…A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as rheumatoid arthritis (RA), by specific targeting of the JAK1 pathway…”
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Re: Chowdhury et al. 2011. J. Hazard. Mater. Disinfection byproducts in Canadian provinces: Associated cancer risks and associated medical expenses. 187: 574–584 by Bull, Richard J., Cotruvo, Joseph A., Fawell, John, Hrudey, Steve E.

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The synergistic effect of sodium chlorite and bromochloroacetic acid on BrO3− -induced renal cell death by Zhang, Xiaoling, Bull, Richard J, Fisher, Jeffery, Cotruvo, Joseph A, Cummings, Brian S

“…Highlights ► Mixtures of water disinfection by-products (DPBs) enhanced renal cell death. ► Increased cell death correlated to increased DNA damage and changes…”
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Mode of Action of Liver Tumor Induction by Trichloroethylene and Its Metabolites, Trichloroacetate and Dichloroacetate by Bull, Richard J.

“…Trichloroethylene (TCE) induces liver cancer in mice but not in rats. Three metabolites of TCE may contribute-chloral hydrate (CH), dichloroacetate (DCA), and…”
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Changes in mRNA and protein expression in the renal cortex of male and female F344 rats treated with bromate by Kolisetty, Narendrababu, Delker, Don A., Muralidhara, Srinivasa, Bull, Richard J., Cotruvo, Joseph A., Fisher, Jeff W., Cummings, Brian S.

“…Bromate (BrO 3 − ), a by-product of ozonation of drinking water, induces nephrotoxicity in male rats at much lower doses than in female rats. This difference…”
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Risk stratification could reduce costs in primary prevention of cardiovascular disease by Dalton, Andrew R H, Bull, Richard J

“…England is rolling out a major primary prevention programme for cardiovascular disease, the NHS Health Check. 1 2 Only patients at high risk of diabetes need a…”
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Association of brominated proteins and changes in protein expression in the rat kidney with subcarcinogenic to carcinogenic doses of bromate by Kolisetty, Narendrababu, Bull, Richard J., Muralidhara, Srinivasa, Costyn, Leah J., Delker, Don A., Guo, Zhongxian, Cotruvo, Joseph A., Fisher, Jeffrey W., Cummings, Brian S.

“…The water disinfection byproduct bromate (BrO3−) produces cytotoxic and carcinogenic effects in rat kidneys. Our previous studies demonstrated that BrO3−…”
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Differences in Phenotype and Cell Replicative Behavior of Hepatic Tumors Induced by Dichloroacetate (DCA) and Trichloroacetate (TCA) by Stauber, Anja J, Bull, Richard J

“…Dichloroacetate (DCA) and trichloroacetate (TCA) are two hepatocarcinogenic by-products of water chlorination. To compare the effects of DCA and TCA on cell…”
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Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform by Staben, Steven T., Ndubaku, Chudi, Blaquiere, Nicole, Belvin, Marcia, Bull, Richard J., Dudley, Danette, Edgar, Kyle, Gray, Daniel, Heald, Robert, Heffron, Timothy P., Jones, Graham E., Jones, Mark, Kolesnikov, Aleks, Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy, McLean, Neville J., Nonomiya, Jim, Olivero, Alan G., Ord, Rachel, Pang, Jodie, Price, Stephen, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Wallin, Jeff, Wang, Lan, Wei, BinQing, Weismann, Christian, Wu, Ping

“…A series of suitable five-membered heterocyclic alternatives to thiophenes within a thienobenzoxepin class of PI3-kinase (PI3K) inhibitors was discovered…”
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The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD by Mete, Antonio, Bowers, Keith, Bull, Richard J., Coope, Helen, Donald, David K., Escott, Katherine J., Ford, Rhonan, Grime, Ken, Mather, Andrew, Ray, Nicholas C., Russell, Vince

“…The design and improvement of a novel series of muscarinic M3 receptor antagonists is described, leading to the identification of AZD8683, which was selected…”
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1 by Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, Adam, Johnson, Tony, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Maxey, Robert J., Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Ubhayakar, Savita, van Abbema, Anne, Ward, Stuart I., Waszkowycz, Bohdan, Zak, Mark

“…The identification of a novel fused triazolo-pyrrolopyridine scaffold, optimized derivatives of which display nanomolar inhibition of Janus kinase 1, is…”
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Absorption and disposition of bromate in F344 rats by Bull, Richard J, Kolisetty, Narendrababu, Zhang, Xiaoling, Muralidhara, Srinivasa, Quiñones, Oscar, Lim, Kok Yong, Guo, Zhongxian, Cotruvo, Joseph A, Fisher, Jeffrey W, Yang, Xiaoxia, Delker, Don, Snyder, Shane A, Cummings, Brian S

“…Abstract Bromate (BrO3− ) is a ubiquitous by-product of using ozone to disinfect water containing bromide (Br− ). The reactivity of BrO3− with biological…”
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Determinants of Whether or Not Mixtures of Disinfection By-Products are Similar by Bull, Richard J., Rice, Glenn, Teuschler, Linda K.

“…Reactive chemicals have been used to disinfect drinking waters for over a century. In the 1970s, it was first observed that the reaction of these chemicals…”
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