Search Results - "Bulitta, J"

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections by Tängdén, T., Ramos Martín, V., Felton, T. W., Nielsen, E. I., Marchand, S., Brüggemann, R. J., Bulitta, J. B., Bassetti, M., Theuretzbacher, U., Tsuji, B. T., Wareham, D. W., Friberg, L. E., De Waele, J. J., Tam, V. H., Roberts, Jason A.

“…Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing. The pharmacokinetics (PK) and pharmacodynamics (PD) of…”
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Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections by PROKOCIMER, P, BIEN, P, SURBER, J, MEHRA, P, DEANDA, C, BULITTA, J. B, COREY, G. R

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Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach by Garonzik, Samira M, Lenhard, Justin R, Forrest, Alan, Holden, Patricia N, Bulitta, Jϋrgen B, Tsuji, Brian T

“…Our objective was to study the pharmacodynamics of daptomycin in the presence of varying concentrations of human serum (HS) in vitro to quantify the fraction…”
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Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii by Smith, N.M., Lenhard, J.R., Boissonneault, K.R., Landersdorfer, C.B., Bulitta, J.B., Holden, P.N., Forrest, A., Nation, R.L., Li, J., Tsuji, B.T.

“…Increased rates of carbapenem-resistant strains of Acinetobacter baumannii have forced clinicians to rely upon last-line agents, such as the polymyxins, or…”
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Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers by BULITTA, J. B, DUFFULL, S. B, KINZIG-SCHIPPERS, M, HOLZGRABE, U, STEPHAN, U, DRUSANO, G. L, SÖRGEL, F

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In pursuit of the triple crown: mechanism-based pharmacodynamic modelling for the optimization of three-drug combinations against KPC-producing Klebsiella pneumoniae by Onufrak, N.J., Smith, N.M., Satlin, M.J., Bulitta, J.B., Tan, X., Holden, P.N., Nation, R.L., Li, J., Forrest, A., Tsuji, B.T., Bulman, Z.P.

“…Optimal combination therapy for Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) is unknown. The present study sought to characterize…”
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Population Pharmacokinetic Comparison and Pharmacodynamic Breakpoints of Ceftazidime in Cystic Fibrosis Patients and Healthy Volunteers by BULITTA, J. B, LANDERSDORFER, C. B, HILTTNER, S. J, DRUSANO, G. L, KINZIG, M, HOLZGRABE, U, STEPHAN, U, SÖRGEL, F

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Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units by Roos, Juliana F., Bulitta, Jurgen, Lipman, Jeffrey, Kirkpatrick, Carl M. J.

“…Objectives: (i) To develop a population pharmacokinetics (PK) model for cefepime in patients in intensive care units (ICUs). (ii) To assess the…”
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Evaluation of enrofloxacin use in koalas (Phascolarctos cinereus) via population pharmacokinetics and Monte Carlo simulation by Black, L. A, Landersdorfer, C. B, Bulitta, J. B, Griffith, J. E, Govendir, M

“…Clinically normal koalas (n = 6) received a single dose of intravenous enrofloxacin (10 mg/kg). Serial plasma samples were collected over 24 h, and…”
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Comparable Population Pharmacokinetics and Pharmacodynamic Breakpoints of Cefpirome in Cystic Fibrosis Patients and Healthy Volunteers by BULITTA, J. B, KINZIG, M, LANDERSDORFER, C. B, HOLZGRABE, U, STEPHAN, U, SÖRGEL, F

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New Semiphysiological Absorption Model To Assess the Pharmacodynamic Profile of Cefuroxime Axetil Using Nonparametric and Parametric Population Pharmacokinetics by BULITTA, J. B, LANDERSDORFER, C. B, KINZIG, M, HOLZGRABE, U, SORGEL, F

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Pharmacokinetics and pharmacodynamics of antibiotics in intensive care by Sörgel, F, Höhl, R, Glaser, R, Stelzer, C, Munz, M, Vormittag, M, Kinzig, M, Bulitta, J, Landersdorfer, C, Junger, A, Christ, M, Wilhelm, M, Holzgrabe, U

“…Optimized dosage regimens of antibiotics have remained obscure since their introduction. During the last two decades pharmacokinetic(PK)-pharmacodynamic(PD)…”
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Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration by Roberts, Jason A, Udy, Andrew A, Bulitta, Juergen B, Stuart, Janine, Jarrett, Paul, Starr, Therese, Lassig-Smith, Melissa, Roberts, Natasha A, Dunlop, Rachel, Hayashi, Yoshiro, Wallis, Steven C, Lipman, Jeffrey

“…Doripenem is a newer carbapenem with little data available to guide effective dosing during renal replacement therapy in critically ill patients. The objective…”
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Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis by Koh, T J, Bulitta, C J, Fleming, J V, Dockray, G J, Varro, A, Wang, T C

“…Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most colorectal cancers and lead to activation of beta-catenin. Whereas…”
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Pharmacokinetics of ertapenem in colorectal tissue by Wittau, M, Scheele, J, Bulitta, J B, Mayer, B, Kaever, V, Burhenne, H, Henne-Bruns, D, Isenmann, R, Brockschmidt, C

“…There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was…”
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ABT-773: Pharmacokinetics and Interactions with Ranitidine and Sucralfate by PLETZ, M. W, PREECHACHATCHAVAL, V, BULITTA, J, ALLEWELT, M, BURKHARDT, O, LODE, H

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Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element by Bulitta, Clemens J, Fleming, John V, Raychowdhury, Raktima, Taupin, Douglas, Rosenberg, Ian, Wang, Timothy C

“…Trefoil factor 2 (TFF2)/spasmolytic polypeptide (SP) is a highly stable peptide which is abundantly expressed and secreted by mucous cells of the stomach and…”
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Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter by Raychowdhury, Raktima, Fleming, John V, McLaughlin, John T, Bulitta, Clemens J, Wang, Timothy C

“…In human gastric cancer cells the human histidine decarboxylase gene is regulated by gastrin through two overlapping cis-acting elements known as gastrin…”
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Mutation analysis of the cationic trypsinogen gene in patients with pancreatic cancer by Hengstler, J G, Bauer, A, Wolf, H K, Bulitta, C J, Tanner, B, Oesch, F, Gebhard, S, Boettger, T

“…Recently, an Arg to His mutation at residue 117 of the cationic trypsinogen gene (Arg117His) has been shown to be associated with hereditary pancreatitis (hp)…”
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Clinical consequences of molecular diagnosis in families with mismatch repair gene germline mutations by PISTORIUS, Steffen R, KRUPPA, Christian, HAAS, Stephan, PLASCHKE, Jens, KRUGER, Stefan, BULITTA, Clemens J, NAGEL, Michael, SAEGER, Hans-Detlev, SCHACKERT, Hans K

“…Hereditary nonpolyposis colorectal cancer (HNPCC), clinically defined by the Amsterdam criteria, is associated with mismatch repair gene germline mutations…”
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