Enhanced and copper concentration dependent virucidal effect against SARS-CoV-2 of electrospun poly(vinylidene difluoride) filter materials

Virucidal filter materials were prepared by electrospinning a solution of 28 wt % poly(vinylidene difluoride) in N,N-dimethylacetamide without and with the addition of 0.25 wt %, 0.75 wt %, 2.0 wt %, or 3.5 wt % Cu(NO3)2 · 2.5H2O as virucidal agent. The fabricated materials had a uniform and defect...

Full description

Saved in:

Bibliographic Details
Published in:	iScience Vol. 27; no. 6; p. 109835
Main Authors:	Bulgarin, Hanna, Thomberg, Thomas, Lust, Andres, Nerut, Jaak, Koppel, Miriam, Romann, Tavo, Palm, Rasmus, Månsson, Martin, Vana, Marko, Junninen, Heikki, Külaviir, Marian, Paiste, Päärn, Kirsimäe, Kalle, Punapart, Marite, Viru, Liane, Merits, Andres, Lust, Enn
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 21-06-2024 Elsevier
Subjects:	engineering materials science materials science engineering
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Virucidal filter materials were prepared by electrospinning a solution of 28 wt % poly(vinylidene difluoride) in N,N-dimethylacetamide without and with the addition of 0.25 wt %, 0.75 wt %, 2.0 wt %, or 3.5 wt % Cu(NO3)2 · 2.5H2O as virucidal agent. The fabricated materials had a uniform and defect free fibrous structure and even distribution of copper nanoclusters. X-ray diffraction analysis showed that during the electrospinning process, Cu(NO3)2 · 2.5H2O changed into Cu2(NO3)(OH)3. Electrospun filter materials obtained by electrospinning were essentially macroporous. Smaller pores of copper nanoclusters containing materials resulted in higher particle filtration than those without copper nanoclusters. Electrospun filter material fabricated with the addition of 2.0 wt % and 3.5 wt % of Cu(NO3)2 · 2.5H2O in a spinning solution showed significant virucidal activity, and there was 2.5 ± 0.35 and 3.2 ± 0.30 logarithmic reduction in the concentration of infectious SARS-CoV-2 within 12 h, respectively. The electrospun filter materials were stable as they retained virucidal activity for three months. [Display omitted] •Cu containing fibrous materials were prepared by electrospinning method•Cu(NO3)2 · 2.5H2O transformed into Cu2(NO3)(OH)3 during electrospinning process•Cu nanoclusters containing material showed very high filtration efficiency•Cu containing material showed very high virudical activity against SARS-CoV-2 Engineering; Materials science
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2589-0042 2589-0042
DOI:	10.1016/j.isci.2024.109835