Cognition as a parameter in monitoring the effect of multiple sclerosis relapse treatment: A prospective controlled study

Cognition as a parameter in monitoring the effect of multiple sclerosis relapse treatment: A prospective controlled study

Cognitive evaluation was considered to be very important in the relapse period, on the basis of the presence of isolated cognitive attacks and the necessity of monitoring the patient both physically and cognitively. People with MS (pwMS) who were hospitalized during relapse were included in the stud...

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Published in:Clinical neurology and neurosurgery Vol. 238; p. 108173
Main Authors: Piri Cinar, B., Baba, C., Demir, S., Uzunkopru, C., Seferoglu, M., Gungor Dogan, I., Cilingir, V., Acikgoz, M., Bulbul, N.G., Sivaci, A.O., Cekic, S., Yigit, P., Eroglu, S., Beckmann, Y., Ozakbas, S.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-03-2024
Elsevier Limited
Subjects:
Chronic Disease
Cognition
Cognition & reasoning
Cognitive ability
Humans
Information processing
Memory
Multiple sclerosis
Multiple Sclerosis - psychology
Neuropsychological Tests
Patients
Prospective Studies
Recurrence
Relapse
Remission
Remission (Medicine)
Steroid treatment
Multiple sclerosis
Relapse
Cognition
Steroid treatment
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Summary:Cognitive evaluation was considered to be very important in the relapse period, on the basis of the presence of isolated cognitive attacks and the necessity of monitoring the patient both physically and cognitively. People with MS (pwMS) who were hospitalized during relapse were included in the study. All MS patients were evaluated by the neurologist with Expanded Disability Status Scale (EDSS), The 9 Hole Peg Test (9HPT) and the Timed 25-Foot Walk Test (T25-FWT). Additionally, all participants were examined cognitively with the Turkish version of the Brief International Cognitive Assessment for MS (BICAMS) battery. Also, schedules were indicated as during relapse before the treatment (pre-treatment) and the first month after relapse (1-month follow-up). A total of 140 MS patients (mean age; 34.98±10.09, mean disease duration; 6.05±5.29 years) and 86 healthy controls (mean age; 36.94±10.83) were included to the present study. The mean EDSS scores in pre-treatment in MS patients was 2.74±1.14 and decreased significantly in the 1-month follow-up (1.74±1.24; p<0.001). The mean SDMT score was lower by 8.76 points in MS patients than in HCs) in pre-treatment and 7.66 points in 1-month follow-up (p<0.001). The mean SDMT scores of all participants increased with measurement time gradually (p<0.001). In this study, it was detected which cognitive domains were affected after relapse treatment and cognitive changes in pwMS during relapse and remission periods compared to the healthy controls. All three BICAMS test scores significantly increased in one-month follow-up than the pre-treatment period. The results showed that CVLT-II and BVMT-R scores improved more in pwMS than in HCs, and also SDMT scores of pwMS showed a trend of increase, but was not a significant improvement. •Cognition should be evaluated in both relapse and remission periods.•It is important to expand the use of cognitive batteries in relapse period.•During relapse period, cognition should be evaluated as well as physical disability.
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ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2024.108173