Search Results - "Bukrinsky, Michael I"

Lipid rafts and pathogens: the art of deception and exploitation by Bukrinsky, Michael I., Mukhamedova, Nigora, Sviridov, Dmitri

“…Lipid rafts, solid regions of the plasma membrane enriched in cholesterol and glycosphingolipids, are essential parts of a cell. Functionally, lipid rafts…”
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Mpox (Monkeypox) Virus and Its Co-Infection with HIV, Sexually Transmitted Infections, or Bacterial Superinfections: Double Whammy or a New Prime Culprit? by Liu, Benjamin M, Rakhmanina, Natella Y, Yang, Zhilong, Bukrinsky, Michael I

“…Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022-2023, due to Clade IIb mpox virus (MPXV),…”
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Trained Immunity and HIV Infection by Sviridov, Dmitri, Miller, Yury I., Bukrinsky, Michael I.

“…Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for…”
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Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system by Schenck, Jessica K, Karl, Molly T, Clarkson-Paredes, Cheryl, Bastin, Ashley, Pushkarsky, Tatiana, Brichacek, Beda, Miller, Robert H, Bukrinsky, Michael I

“…HIV-associated neurocognitive disorders (HAND) are a spectrum of cognitive impairments that continue to affect approximately half of all HIV-positive…”
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Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A by Damsker, Jesse M., Bukrinsky, Michael I., Constant, Stephanie L.

“…The recruitment and trafficking of leukocytes are essential aspects of the inflammatory process. Although chemokines are thought to be the main regulators of…”
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Editorial On “Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy” by Golubovskaya, Vita, Bukrinsky, Michael I, Grizzi, Fabio

“…The term “Exosomes” defines small extracellular vesicles, ranging from 30 to 150 nm in diameter, secreted by most eukaryotic cells into surrounding body fluids…”
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Targeting the chemotactic function of CD147 reduces collagen-induced arthritis by Damsker, Jesse M, Okwumabua, Ifeanyi, Pushkarsky, Tatiana, Arora, Kamalpreet, Bukrinsky, Michael I, Constant, Stephanie L

“…CD147 is a type I transmembrane glycoprotein expressed on a wide variety of cell types, including all leucocytes. While CD147 is best known as a potent inducer…”
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HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni by Suttiprapa, Sutas, Rinaldi, Gabriel, Tsai, Isheng J, Mann, Victoria H, Dubrovsky, Larisa, Yan, Hong-Bin, Holroyd, Nancy, Huckvale, Thomas, Durrant, Caroline, Protasio, Anna V, Pushkarsky, Tatiana, Iordanskiy, Sergey, Berriman, Matthew, Bukrinsky, Michael I, Brindley, Paul J

“…Schistosomiasis is the most important helminthic disease of humanity in terms of morbidity and mortality. Facile manipulation of schistosomes using…”
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Extracellular Cyclophilins Contribute to the Regulation of Inflammatory Responses by Arora, Kamalpreet, Gwinn, William M, Bower, Molly A, Watson, Alan, Okwumabua, Ifeanyi, MacDonald, H. Robson, Bukrinsky, Michael I, Constant, Stephanie L

“…The main regulators of leukocyte trafficking during inflammatory responses are chemokines. However, another class of recently identified chemotactic agents is…”
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Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors by Adzhubei, Alexei A., Kulkarni, Amol, Tolstova, Anna P., Anashkina, Anastasia A., Sviridov, Dmitri, Makarov, Alexander A., Bukrinsky, Michael I.

“…[Display omitted] HIV-1 infection impairs cellular cholesterol efflux by downmodulating the cholesterol transporter ABCA1, leading to metabolic co-morbidities…”
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The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications by Ballout, Rami A., Sviridov, Dmitri, Bukrinsky, Michael I., Remaley, Alan T.

“…Drug repurposing is potentially the fastest available option in the race to identify safe and efficacious drugs that can be used to prevent and/or treat…”
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Atherosclerosis in subjects newly diagnosed with human immunodeficiency virus infection by Kirichenko, Tatiana V, Myasoedova, Veronika A, Shimonova, Tatiana E, Melnichenko, Alexandra A, Sviridov, Dmitri, Sobenin, Igor A, Mazus, Alexey I, Orekhov, Alexander N, Bukrinsky, Michael I

“…HIV infection is associated with the increased risk of cardiovascular disease (CVD), even in patients successfully treated with the combination antiretroviral…”
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Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention by Gwinn, William M, Damsker, Jesse M, Falahati, Rustom, Okwumabua, Ifeanyi, Kelly-Welch, Ann, Keegan, Achsah D, Vanpouille, Christophe, Lee, James J, Dent, Lindsay A, Leitenberg, David, Bukrinsky, Michael I, Constant, Stephanie L

“…Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon…”
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Vpr-Host Interactions During HIV-1 Viral Life Cycle by Zhao, Richard Y., Li, Ge, Bukrinsky, Michael I.

“…Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is a multifunctional viral protein that plays important role at multiple stages of the HIV-1…”
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Cyclosporin Derivative Discriminates between Extracellular and Intracellular Cyclophilins by Malešević, Miroslav, Kühling, Jan, Erdmann, Frank, Balsley, Molly A, Bukrinsky, Michael I, Constant, Stephanie L, Fischer, Gunter

“…Trimesic acid amide serves as a scaffold for a lipophilic cyclophilin inhibitor, a fluorescent rhodamine dye (TAMRA), and a (D‐Glu)6 oligopeptide residue…”
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Cell Surface Expression of CD147/EMMPRIN Is Regulated by Cyclophilin 60 by Pushkarsky, Tatiana, Yurchenko, Vyacheslav, Vanpouille, Christophe, Brichacek, Beda, Vaisman, Iosif, Hatakeyama, Shigetsugu, Nakayama, Keiichi I., Sherry, Barbara, Bukrinsky, Michael I.

“…CD147, also known as extracellular matrix metalloproteinase inducer, is a regulator of matrix metalloproteinase production and also serves as a signaling…”
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Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance by Pushkarsky, Tatiana, Ward, Adam, Ivanov, Andrey, Lin, Xionghao, Sviridov, Dmitri, Nekhai, Sergei, Bukrinsky, Michael I.

“…HIV-associated neurocognitive disorders (HAND) is a term used to describe a variety of neurological impairments observed in HIV-infected individuals. The…”
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Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus by Weinstein, Raymond S, Weinstein, Michael M, Alibek, Kenneth, Bukrinsky, Michael I, Brichacek, Beda

“…At present, the relatively sudden appearance and explosive spread of HIV throughout Africa and around the world beginning in the 1950s has never been…”
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Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells by Dubrovsky, Larisa, Brichacek, Beda, Prashant, N M, Pushkarsky, Tatiana, Mukhamedova, Nigora, Fleetwood, Andrew J, Xu, Yangsong, Dragoljevic, Dragana, Fitzgerald, Michael, Horvath, Anelia, Murphy, Andrew J, Sviridov, Dmitri, Bukrinsky, Michael I

“…A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a…”
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Modelling interaction between HIV-1 Nef and calnexin by Adzhubei, Alexei A, Anashkina, Anastasia A, Tkachev, Yaroslav V, Kravatsky, Yury V, Pushkarsky, Tatiana, Kulkarni, Amol, Makarov, Alexander A, Bukrinsky, Michael I

“…BACKGROUND:HIV-associated atherosclerosis is a major co-morbidity due in part to systemic effects of the virus on cholesterol metabolism. HIV protein Nef plays…”
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