Search Results - "Bukosza, Nora"

Lymphatic exosomes promote dendritic cell migration along guidance cues by Brown, Markus, Johnson, Louise A, Leone, Dario A, Majek, Peter, Vaahtomeri, Kari, Senfter, Daniel, Bukosza, Nora, Schachner, Helga, Asfour, Gabriele, Langer, Brigitte, Hauschild, Robert, Parapatics, Katja, Hong, Young-Kwon, Bennett, Keiryn L, Kain, Renate, Detmar, Michael, Sixt, Michael, Jackson, David G, Kerjaschki, Dontscho

“…Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study, we report that LECs also release…”
Get full text

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis by Boehm, Michael, Bukosza, Eva Nora, Huttary, Nicole, Herzog, Rebecca, Aufricht, Christoph, Kratochwill, Klaus, Gebeshuber, Christoph A

“…Focal and Segmental Glomerulosclerosis (FSGS) is a severe glomerulopathy that frequently leads to end stage renal disease. Only a subset of patients responds…”
Get full text

Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation by Tod, Pál, Bukosza, Eva Nora, Róka, Beáta, Kaucsár, Tamás, Fintha, Attila, Krenács, Tibor, Szénási, Gábor, Hamar, Péter

“…(1) Background: Successful treatment of acute kidney injury (AKI)-induced chronic kidney disease (CKD) is unresolved. We aimed to characterize the time-course…”
Get full text

ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS by Bukosza, Eva Nora, Kornauth, Christoph, Hummel, Karin, Schachner, Helga, Huttary, Nicole, Krieger, Sigurd, Nöbauer, Katharina, Oszwald, André, Razzazi Fazeli, Ebrahim, Kratochwill, Klaus, Aufricht, Christoph, Szénási, Gabor, Hamar, Peter, Gebeshuber, Christoph A

“…The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and…”
Get full text

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice by Kölling, Malte, Kaucsar, Tamas, Schauerte, Celina, Hübner, Anika, Dettling, Angela, Park, Joon-Keun, Busch, Martin, Wulff, Xaver, Meier, Matthias, Scherf, Kristian, Bukosza, Nóra, Szénási, Gábor, Godó, Mária, Sharma, Amit, Heuser, Michael, Hamar, Peter, Bang, Claudia, Haller, Hermann, Thum, Thomas, Lorenzen, Johan M.

“…Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are powerful regulators of the genome, and global expression profiling revealed…”
Get full text

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats by Bukosza, Eva Nora, Kaucsár, Tamás, Godó, Mária, Lajtár, Enikő, Tod, Pál, Koncsos, Gábor, Varga, Zoltán V, Baranyai, Tamás, Nguyen, Minh Tu, Schachner, Helga, Sőti, Csaba, Ferdinandy, Péter, Giricz, Zoltán, Szénási, Gábor, Hamar, Péter

“…Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired…”
Get full text

Podocyte RNA sequencing reveals Wnt- and ECM-associated genes as central in FSGS by Bukosza, Eva Nora, Kratochwill, Klaus, Kornauth, Christoph, Schachner, Helga, Aufricht, Christoph, Gebeshuber, Christoph A

“…Loss of podocyte differentiation can cause nephrotic-range proteinuria and Focal and Segmental Glomerulosclerosis (FSGS). As specific therapy is still lacking,…”
Get full text

Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress by Koncsos, Gábor, Varga, Zoltán V, Baranyai, Tamás, Boengler, Kerstin, Rohrbach, Susanne, Li, Ling, Schlüter, Klaus-Dieter, Schreckenberg, Rolf, Radovits, Tamás, Oláh, Attila, Mátyás, Csaba, Lux, Árpád, Al-Khrasani, Mahmoud, Komlódi, Tímea, Bukosza, Nóra, Máthé, Domokos, Deres, László, Barteková, Monika, Rajtík, Tomáš, Adameová, Adriana, Szigeti, Krisztián, Hamar, Péter, Helyes, Zsuzsanna, Tretter, László, Pacher, Pál, Merkely, Béla, Giricz, Zoltán, Schulz, Rainer, Ferdinandy, Péter

“…Although incidence and prevalence of prediabetes are increasing, little is known about its cardiac effects. Therefore, our aim was to investigate the effect of…”
Get more information

Selegiline reduces adiposity induced by high‐fat, high‐sucrose diet in male rats by Nagy, Csilla Terézia, Koncsos, Gábor, Varga, Zoltán V, Baranyai, Tamás, Tuza, Sebestyén, Kassai, Ferenc, Ernyey, Aliz Judit, Gyertyán, István, Király, Kornél, Oláh, Attila, Radovits, Tamás, Merkely, Béla, Bukosza, Nóra, Szénási, Gábor, Hamar, Péter, Mathé, Domokos, Szigeti, Krisztián, Pelyhe, Csilla, Jelemenský, Marek, Onódi, Zsófia, Helyes, Zsuzsanna, Schulz, Rainer, Giricz, Zoltán, Ferdinandy, Péter

“…Background and Purpose Incidence and severity of obesity are increasing worldwide, however, efficient and safe pharmacological treatments are not yet…”
Get full text

Delayed Contralateral Nephrectomy Halted Post-Ischemic Renal Fibrosis Progression and Inhibited the Ischemia-Induced Fibromir Upregulation in Mice by Róka, Beáta, Tod, Pál, Kaucsár, Tamás, Bukosza, Éva Nóra, Vörös, Imre, Varga, Zoltán V., Petrovich, Balázs, Ágg, Bence, Ferdinandy, Péter, Szénási, Gábor, Hamar, Péter

“…(1) Background: Ischemia reperfusion (IR) is the leading cause of acute kidney injury (AKI) and results in predisposition to chronic kidney disease. We…”
Get full text

Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO) by Wolf, Dennis, Bukosza, Nora, Engel, David, Poggi, Marjorie, Jehle, Felix, Anto Michel, Nathaly, Chen, Yung-Chih, Colberg, Christian, Hoppe, Natalie, Dufner, Bianca, Boon, Louis, Blankenbach, Hermann, Hilgendorf, Ingo, von Zur Muhlen, Constantin, Reinöhl, Jochen, Sommer, Björn, Marchini, Timoteo, Febbraio, Mark A, Weber, Christian, Bode, Christoph, Peter, Karlheinz, Lutgens, Esther, Zirlik, Andreas

“…Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, α β ) is a classic adhesion receptor critically…”
Get more information

INFLAMMATION, BUT NOT RECRUITMENT, OF ADIPOSE TISSUE MACROPHAGES REQUIRES SIGNALING THROUGH MAC-1 IN DIET-INDUCED OBESITY (DIO) by Wolf, Dennis, Michel, Nathaly Anto, Nora, Bukosza, Engel, David, Poggi, Marjorie, Weber, Christian, Bode, Christoph, Peter, Karlheinz, Lutgens, Esther, Zirlik, Andreas

“…[...]specific inhibition of Mac-1's adhesive interaction to its biased agonist CD40L by the novel peptide inhibitor cM7 reduced T cell activation, but hardly…”
Get full text

Interruption of classic CD40L-CD40 signalling but not of the novel CD40L-Mac-1 interaction limits arterial neointima formation in mice by Willecke, F, Tiwari, S, Rupprecht, B, Wolf, D, Hergeth, S, Hoppe, N, Dufner, B, Schulte, L, Anto Michel, N, Bukosza, N, Marchini, T, Jäckel, M, Stachon, P, Hilgendorf, I, Zeschky, K, Schleicher, R, Langer, H F, von Zur Muhlen, C, Bode, C, Peter, K, Zirlik, A

“…The co-stimulatory immune molecule CD40L figures prominently in a variety of inflammatory conditions including arterial disease. Recently, we made the…”
Get more information

FP059THE KIDNEY IS RELATIVELY RESISTANT TO OBESITY-RELATED COMORBIDITY IN PREDIABETIC LONG EVANS RATS FED A HIGH FAT DIET by Bukosza, Eva Nora, Kaucsár, Tamás, Godó, Mária, Lajtár, Enikő, Tod, Pál, Koncsos, Gábor, Varga, Zoltán, Nguyen, Minhtu, Schachner, Helga, Sőti, Csaba, Giricz, Zoltán, Szénási, Gábor, Hamar, Peter

Get full text

Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice by Wolf, Dennis, Jehle, Felix, Michel, Nathaly Anto, Bukosza, Eva Nora, Rivera, Jennifer, Chen, Yung Chih, Hoppe, Natalie, Dufner, Bianca, Rodriguez, Alexandra Ortiz, Colberg, Christian, Nieto, Leandro, Rupprecht, Benjamin, Wiedemann, Ansgar, Schulte, Lisa, Peikert, Alexander, Bassler, Nicole, Lozhkin, Andrey, Hergeth, Sonja Patricia, Stachon, Peter, Hilgendorf, Ingo, Willecke, Florian, von zur Mühlen, Constantin, von Elverfeldt, Dominik, Binder, Christoph J, Aichele, Peter, Varo, Nerea, Febbraio, Mark A, Libby, Peter, Bode, Christoph, Peter, Karlheinz, Zirlik, Andreas

“…BACKGROUND—Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis. Here, we tested the…”
Get full text

MP248RENAL FIBROSIS PROGRESSION IS HALTED BY DELAYED REMOVAL OF THE INTACT KIDNEY AFTER UNILATERAL RENAL ISCHEMIA IN MICE by Bukosza, Nóra É., Kaucsár, Tamás, Godó, Mária, Tod, Pál, Szénási, Gábor, Hamar, Péter

Get full text