Search Results - "Bukong, Terence N."

Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro‐RNA 155 in Alcoholic Liver Disease by Babuta, Mrigya, Furi, Istvan, Bala, Shashi, Bukong, Terence N., Lowe, Patrick, Catalano, Donna, Calenda, Charles, Kodys, Karen, Szabo, Gyongyi

“…Cellular homeostais, that is normally maintained through autophagy, is disrupted in alcoholic liver disease (ALD). Because autophagy and exosome biogenesis…”
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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90 by Bukong, Terence N, Momen-Heravi, Fatemeh, Kodys, Karen, Bala, Shashi, Szabo, Gyongyi

“…Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited therapeutic benefits. Evidence suggests that exosomes can transfer genetic…”
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Versican: a novel modulator of hepatic fibrosis by Bukong, Terence N, Maurice, Sean B, Chahal, Barinder, Schaeffer, David F, Winwood, Paul J

“…Little is known about the deposition and turnover of proteoglycans in liver fibrosis, despite their abundance in the extracellular matrix. Versican plays…”
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Alcohol Facilitates HCV RNA Replication Via Up-Regulation of miR-122 Expression and Inhibition of Cyclin G1 in Human Hepatoma Cells by Hou, Wei, Bukong, Terence N., Kodys, Karen, Szabo, Gyongyi

“…Background Clinical studies demonstrate synergistic liver damage by alcohol and hepatitis C virus (HCV); however, the mechanisms by which alcohol promotes HCV…”
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Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway by Marban, Céline, McCabe, Aine, Bukong, Terence N, Hall, William W, Sheehy, Noreen

“…In contrast with human T-cell leukemia virus type 1 (HTLV-1) that causes ATL (adult T-cell leukemia), HTLV-2 has not been causally linked to malignant disease…”
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Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice by Ganz, Michal, Bukong, Terence N, Csak, Timea, Saha, Banishree, Park, Jin-Kyu, Ambade, Aditya, Kodys, Karen, Szabo, Gyongyi

“…Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple 'hits' have been reported to contribute to NAFLD progression to non-alcoholic…”
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Human ezrin‐moesin‐radixin proteins modulate hepatitis C virus infection by Bukong, Terence N., Kodys, Karen, Szabo, Gyongyi

“…Host cytoskeletal proteins of the ezrin‐moesin‐radixin (EMR) family have been shown to modulate single‐stranded RNA virus infection through regulating stable…”
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Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease by Bukong, Terence N., Iracheta‐Vellve, Arvin, Saha, Banishree, Ambade, Aditya, Satishchandran, Abhishek, Gyongyosi, Benedek, Lowe, Patrick, Catalano, Donna, Kodys, Karen, Szabo, Gyongyi

“…The spectrum of alcoholic liver disease (ALD) is a major cause of mortality with limited therapies available. Because alcohol targets numerous signaling…”
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Ethanol facilitates hepatitis C virus replication via up‐regulation of GW182 and heat shock protein 90 in human hepatoma cells by Bukong, Terence N., Hou, Wei, Kodys, Karen, Szabo, Gyongyi

“…Alcohol use and hepatitis C virus (HCV) infection synergize to cause liver damage, and microRNA‐122 (miR‐122) appears to play a key role in this process…”
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Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice by Bukong, Terence N., Iracheta-Vellve, Arvin, Gyongyosi, Benedek, Ambade, Aditya, Catalano, Donna, Kodys, Karen, Szabo, Gyongyi

“…Background Binge drinking is increasingly recognized as an important cause of liver disease with limited therapeutic options for patients. Binge alcohol use,…”
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Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease by Adejumo, Adeyinka C., Ajayi, Tokunbo O., Adegbala, Oluwole M., Adejumo, Kelechi L., Alliu, Samson, Akinjero, Akintunde M., Onyeakusi, Nnaemeka E., Ojelabi, Ogooluwa, Bukong, Terence N.

“…Background Abusive alcohol use has well‐established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS),…”
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Higher odds of irritable bowel syndrome among hospitalized patients using cannabis: a propensity-matched analysis by Adejumo, Adeyinka C, Ajayi, Tokunbo O, Adegbala, Oluwole M, Bukong, Terence N

“…BACKGROUNDThe endogenous cannabinoid system modulates many brain–gut and gut–brain physiologic pathways, which are postulated to be dysfunctional in irritable…”
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Alcohol and HCV: implications for liver cancer by Szabo, Gyongyi, Saha, Banishree, Bukong, Terence N

“…Liver cancers are one of the deadliest known malignancies which are increasingly becoming a major public health problem in both developed and developing…”
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Sa1028 Human Ezrin-Moesin-Radixin Proteins Modulate Hepatitis C Virus Infection by Bukong, Terence N, Kodys, Karen, Szabo, Gyongyi

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miR-155 Dependent Dysregulation of Autophagy in Hepatocytes and Macrophages Drives the Development of Ald By Exploiting the Exosomal Pathway by Furi, Istvan, Bukong, Terence N, Bala, Shashi, Lowe, Patrick, Iracheta-Vellve, Arvin, Kodys, Karen, Ambade, Aditya, Szabo, Gyongyi

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Reduced Neutrophil Extracellular Trap Formation and their Impaired Clearance by Macrophages Exacerbates Liver Injury in Alcoholic Liver Disease by Bukong, Terence N, Saha, Banishree, Iracheta-Vellve, Arvin, Adejumo, Adeyinka C, Furi, Istvan, Ambade, Aditya, Gyongyosi, Benedek, Lowe, Patrick, Catalano, Donna, Kodys, Karen, Szabo, Gyongyi

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Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes by Bukong, Terence N., Lo, Tracie, Szabo, Gyongyi, Dolganiuc, Angela

“…Background/Aims Liver diseases are common in the United States and often require liver transplantation; however, donated organs are limited and thus…”
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A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry by Bukong, Terence N., Kodys, Karen, Szabo, Gyongyi

“…Hepatitis C virus infection of hepatocytes is a multistep process involving the interaction between viral and host cell molecules. Recently, we identified…”
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801 Calcium-Dependent Signaling, via Calcineurin and NFAT, Is Key to Steatosis in Alcoholic Liver Disease (ALD) in Mice by Bukong, Terence N, Lo, Tracie C, Sato, Keisaku, Dolganiuc, Angela

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Su1716 Large-Conductance Calcium-Activated Potassium (MaxiK) Channels Protect From Progression of Hepatic Steatosis (HS) to Steatohepatitis (HS) in Alcoholic Liver Disease (ALD) in Mice by Bukong, Terence N, Lo, Tracie Chui, Sato, Keisaku, Tournade, Christopher D, Dolganiuc, Angela

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