Search Results - "Bukkapatnam, Sanjana"

Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma by Knitz, Michael W., Darragh, Laurel B., Bickett, Thomas E., Bhatia, Shilpa, Bukkapatnam, Sanjana, Gadwa, Jacob, Piper, Miles, Corbo, Sophia, Nguyen, Diemmy, Van Court, Benjamin, Oweida, Ayman, Karam, Sana D.

“…Resistance to radiation therapy (RT) remains an obstacle in HPV-negative head and neck squamous cell carcinomas (HNSCCs)—even with a combined RT-immunotherapy…”
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EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment by Bhatia, Shilpa, Nguyen, Diemmy, Darragh, Laurel B., Van Court, Benjamin, Sharma, Jaspreet, Knitz, Michael W., Piper, Miles, Bukkapatnam, Sanjana, Gadwa, Jacob, Bickett, Thomas E., Bhuvane, Shiv, Corbo, Sophia, Wu, Brian, Lee, Yichien, Fujita, Mayumi, Joshi, Molishree, Heasley, Lynn E., Ferris, Robert L., Rodriguez, Olga, Albanese, Christopher, Kapoor, Mohit, Pasquale, Elena B., Karam, Sana D.

“…Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of…”
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Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma by Bhatia, Shilpa, Hirsch, Kellen, Bukkapatnam, Sanjana, Baig, Nimrah A, Oweida, Ayman, Griego, Anastacia, Calame, Dylan, Sharma, Jaspreet, Donson, Andrew, Foreman, Nicholas, Albanese, Christopher, Venkataraman, Sujatha, Vibhakar, Rajeev, Karam, Sana D

“…Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and…”
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Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration by Oweida, Ayman, Hararah, Mohammad K, Phan, Andy, Binder, David, Bhatia, Shilpa, Lennon, Shelby, Bukkapatnam, Sanjana, Van Court, Benjamin, Uyanga, Nomin, Darragh, Laurel, Kim, Hyun Min, Raben, David, Tan, Aik Choon, Heasley, Lynn, Clambey, Eric, Nemenoff, Raphael, Karam, Sana D

“…Radiotherapy (RT) can transform the immune landscape and render poorly immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response…”
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Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers by Bhatia, Shilpa, Sharma, Jaspreet, Bukkapatnam, Sanjana, Oweida, Ayman, Lennon, Shelby, Phan, Andy, Milner, Dallin, Uyanga, Nomin, Jimeno, Antonio, Raben, David, Somerset, Hilary, Heasley, Lynn, Karam, Sana D

“…The clinical success of targeted therapies such as cetuximab and radiotherapy (RT) is hampered by the low response rates and development of therapeutic…”
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Abstract 5035: Blockade of EphB4-ephrin-B2 interaction remodels the tumor immune microenvironment in head and neck cancers by Bhatia, Shilpa, Oweida, Ayman, Lennon, Shelby, Darragh, Laurel, Bukkapatnam, Sanjana, Court, Benjamin Van, Raben, David, Serkova, Natalie, Jimeno, Antonio, Clambey, Eric, Pasquale, Elena, Karam, Sana

“…Abstract Introduction: Identifying targets in the tumor microenvironment (TME) that act as barriers to an effective anti-tumor immune response has become an…”
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Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor by Bhatia, Shilpa, Griego, Anastacia, Lennon, Shelby, Oweida, Ayman, Sharma, Jaspreet, Rohmer, Christina, Uyanga, Nomin, Bukkapatnam, Sanjana, Van Court, Benjamin, Raben, David, Young, Christian, Heasley, Lynn, Karam, Sana D

“…Eph proteins have emerged as critical drivers affecting tumor growth and progression in human malignancies. Our The Cancer Genome Atlas (TCGA) data analysis…”
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Abstract 2946: Role of EphB3 receptor in mediating head and neck tumor growth, cell migration, and response to PI3K inhibitor by Bhatia, Shilpa, Griego, Anastacia, Lennon, Shelby, Oweida, Ayman, Sharma, Jaspreet, Rohmer, Christina, Uyanga, Nomin, Bukkapatnam, Sanjana, Court, Benjamin Van, Raben, David, Young, Christian, Heasley, Lynn, Karam, Sana D.

“…Abstract Introduction: Eph proteins have emerged as critical drivers affecting tumor growth and progression in human malignancies. Dysregulated expression of…”
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Abstract 4169: Inhibition of EphB4-ephrin-B2 signaling results in enhanced sensitivity to cetuximab-radiation therapy in head and neck cancers by Bhatia, Shilpa, Sharma, Jaspreet, Bukkapatnam, Sanjana, Oweida, Ayman, Lennon, Shelby, Gill, Parkash, Jimeno, Antonio, Raben, David, Heasley, Lynn, Karam, Sana D.

“…Abstract Introduction: The management of locally-advanced head and neck cancer patients relies on the combination treatment involving 7 weeks of radiation…”
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The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme by Bhatia, Shilpa, Bukkapatnam, Sanjana, Van Court, Benjamin, Phan, Andy, Oweida, Ayman, Gadwa, Jacob, Mueller, Adam C., Piper, Miles, Darragh, Laurel, Nguyen, Diemmy, Gilani, Ahmed, Knitz, Michael, Bickett, Thomas, Green, Adam, Venkataraman, Sujatha, Vibhakar, Rajeev, Cittelly, Diana, Karam, Sana D.

“…The aggressive nature of glioblastoma multiforme (GBM) may be attributed to the dysregulation of pathways driving both proliferation and invasion. EphrinB2, a…”
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Abstract 4173: Inhibition of EphB4-ephrinB2 signaling increases efficacy of radiation in pancreatic ductal adenocarcinoma by Lennon, Shelby, Bhatia, Shilpa, Oweida, Ayman, Sharma, Jaspreet, Phan, Andy, Bukkapatnam, Sanjana, Uyanga, Nomin, Pitts, Todd, Leong, Stephen, Goodman, Karyn, Raben, David, Pasquale, Elena, Martinez-Torrecuadrada, Jorge, Karam, Sana

“…Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the United States. Survival rates are…”
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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC by Gadwa, Jacob, Amann, Maria, Bickett, Thomas E., Knitz, Michael W., Darragh, Laurel B., Piper, Miles, Van Court, Benjamin, Bukkapatnam, Sanjana, Pham, Tiffany T., Wang, Xiao-Jing, Saviola, Anthony J., Deak, Laura Codarri, Umaña, Pablo, Klein, Christian, D’Alessandro, Angelo, Karam, Sana D.

“…The implementation of cancer immunotherapies has seen limited clinical success in head and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which…”
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Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs by Darragh, Laurel B, Nguyen, Alexander, Pham, Tiffany T, Idlett-Ali, Shaquia, Knitz, Michael W, Gadwa, Jacob, Bukkapatnam, Sanjana, Corbo, Sophia, Olimpo, Nicholas A, Nguyen, Diemmy, Van Court, Benjamin, Neupert, Brooke, Yu, Justin, Ross, Richard B, Corbisiero, Michaele, Abdelazeem, Khalid N M, Maroney, Sean P, Galindo, David C, Mukdad, Laith, Saviola, Anthony, Joshi, Molishree, White, Ruth, Alhiyari, Yazeed, Samedi, Von, Van Bokhoven, Adrie, St John, Maie, Karam, Sana D

“…Perineural invasion (PNI) and nerve density within the tumor microenvironment (TME) have long been associated with worse outcomes in head and neck squamous…”
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