Search Results - "Bukanova, Julia"

Factors promoting the release of picrotoxin from the trap in the GABA(A) receptor pore by Bukanova, Julia V., Solntseva, Elena I., Skrebitsky, Vladimir G.

“…Picrotoxin (PTX), a convulsant of plant origin, has been used in many studies as research tool. PTX is the open channel blocker of the GABAA receptor (GABAAR)…”
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Pregnane neurosteroids exert opposite effects on GABA and glycine‐induced chloride current in isolated rat neurons by Solntseva, Elena I., Bukanova, Julia V., Skrebitsky, Vladimir G., Kudova, Eva

“…The ability of endogenous neurosteroids (NSs) with pregnane skeleton modified at positions C‐3 and C‐5 to modulate the functional activity of inhibitory…”
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Positive allosteric modulators of GABAA receptor restore chloride current from blockade by competitive antagonists in a ligand-dependent manner by Bukanova, Julia V., Kondratenko, Rodion V., Solntseva, Elena I.

“…γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter. GABA receptor type A (GABAAR) possesses binding sites for a large group of pharmacological…”
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Corticosteroids as Selective and Effective Modulators of Glycine Receptors by Solntseva, Elena I., Bukanova, Julia V., Kondratenko, Rodion, Kudova, Eva

“…The mechanism of the negative impact of corticosteroids on the induction and progress of mental illness remains unclear. In this work, we studied the effects…”
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Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes by Bukanova, Julia V, Solntseva, Elena I, Kudova, Eva

“…The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds - ) to influence the functional activity of…”
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The mechanisms of potentiation and inhibition of GABA A receptors by non-steroidal anti-inflammatory drugs, mefenamic and niflumic acids by Rossokhin, Alexey V, Sharonova, Irina N, Dvorzhak, Anton, Bukanova, Julia V, Skrebitsky, Vladimir G

“…Fenamates mefanamic and niflumic acids (MFA and NFA) induced dual potentiating and inhibitory effects on GABA currents recorded in isolated cerebellar Purkinje…”
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Use-dependent inhibition of glycine-activated chloride current in rat neurons by β-amyloid peptide pretreated with hexafluoroisopropanol by Solntseva, Elena I, Bukanova, Julia V

“…Hexafluoroisopropanol (HFIP) is a nonpolar organic solvent that is often used to prepare β-amyloid peptide (Aβ) samples. In this work, we compare the effects…”
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The mechanisms of potentiation and inhibition of GABAA receptors by non-steroidal anti-inflammatory drugs, mefenamic and niflumic acids by Rossokhin, Alexey V., Sharonova, Irina N., Dvorzhak, Anton, Bukanova, Julia V., Skrebitsky, Vladimir G.

“…Fenamates mefanamic and niflumic acids (MFA and NFA) induced dual potentiating and inhibitory effects on GABA currents recorded in isolated cerebellar Purkinje…”
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Modulation of GABA and glycine receptors in rat pyramidal hippocampal neurones by 3α5β-pregnanolone derivatives by Bukanova, Julia V., Solntseva, Elena I., Kolbaev, Sergey N., Kudova, Eva

“…The ability of pregnanolone glutamate (PA-Glu), pregnanolone hemisuccinate (PA-hSuc) and pregnanolone hemipimelate (PA-hPim), neuroactive steroids with a…”
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Epipregnanolone as a Positive Modulator of GABAA Receptor in Rat Cerebellar and Hippocampus Neurons by Bukanova, Julia, Solntseva, Elena, Kondratenko, Rodion, Kudova, Eva

“…Epipregnanolone (3β-hydroxy-5β-pregnan-20-one, Epi) is an endogenous steroid with important physiological effects and high affinity for GABAA receptors. The…”
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Glycine receptor in hippocampal neurons as a target for action of extracellular cyclic nucleotides by Bukanova, Julia V, Solntseva, Elena I, Kondratenko, Rodion V, Skrebitsky, Vladimir G

“…Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are well known intracellular second messengers. At present study, we describe…”
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Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABAA receptors by Tikhonova, Tatyana A., Rassokhina, Irina V., Kondrakhin, Eugeny A., Fedosov, Mikhail A., Bukanova, Julia V., Rossokhin, Alexey V., Sharonova, Irina N., Kovalev, Georgy I., Zavarzin, Igor V., Volkova, Yulia A.

“…Structural basis for activity of benzo[d]imidazo[2,1-b]thiazoles were proposed using extensive molecular docking studies. [Display omitted] •Three series of…”
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Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABA A receptors by Tikhonova, Tatyana A, Rassokhina, Irina V, Kondrakhin, Eugeny A, Fedosov, Mikhail A, Bukanova, Julia V, Rossokhin, Alexey V, Sharonova, Irina N, Kovalev, Georgy I, Zavarzin, Igor V, Volkova, Yulia A

“…Structure-activity relationship studies were conducted in the search for 1,3-thiazole isosteric analogs of imidazopyridine drugs (Zolpidem, Alpidem). Three…”
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Block of GABA(A) receptor ion channel by penicillin: electrophysiological and modeling insights toward the mechanism by Rossokhin, Alexey V, Sharonova, Irina N, Bukanova, Julia V, Kolbaev, Sergey N, Skrebitsky, Vladimir G

“…GABA(A) receptors (GABA(A)R) mainly mediate fast inhibitory neurotransmission in the central nervous system. Different classes of modulators target GABA(A)R…”
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Block of GABAA receptor ion channel by penicillin: Electrophysiological and modeling insights toward the mechanism by Rossokhin, Alexey V., Sharonova, Irina N., Bukanova, Julia V., Kolbaev, Sergey N., Skrebitsky, Vladimir G.

“…GABAA receptors (GABAAR) mainly mediate fast inhibitory neurotransmission in the central nervous system. Different classes of modulators target GABAAR…”
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Donepezil in low micromolar concentrations modulates voltage-gated potassium currents in pyramidal neurons of rat hippocampus by Solntseva, Elena I., Bukanova, Julia V., Skrebitsky, Vladimir G.

“…► Antiamnestic donepezil. ► Voltage-gated potassium currents. ► Rat hippocampal neurons. Donepezil is a cholinesterase inhibitor widely used for the treatment…”
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Donepezil in a Narrow Concentration Range Augments Control and Impaired by Beta-Amyloid Peptide Hippocampal LTP in NMDAR-Independent Manner by Kapai, Nadezhda A., Bukanova, Julia V., Solntseva, Elena I., Skrebitsky, Vladimir G.

“…Acetylcholinesterase (AChE) inhibitor donepezil is widely used for the treatment of Alzheimer’s disease (AD). The mechanisms of therapeutic effects of the drug…”
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Donepezil is a strong antagonist of voltage-gated calcium and potassium channels in molluscan neurons by Solntseva, Elena I., Bukanova, Julia V., Marchenko, Evgeny, Skrebitsky, Vladimir G.

“…Donepezil is an acetylcholinesterase inhibitor used in Alzheimer’s disease therapy. The neuroprotective effect of donepezil has been demonstrated in a number…”
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The effects of ferric iron on voltage-gated potassium currents in molluscan neurons by Bukanova, Julia V, Solntseva, Elena I, Skrebitsky, Vladimir G

“…In isolated neurons of Helix pomatia, a two-microelectrode voltage clamp technique was used to study the effect of Fe on voltage-gated potassium currentsa…”
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Binding of Donepezil with External Mouth of K⁺-Channels of Molluscan Neurons by Solntseva, Elena I, Bukanova, Julia V, Marchenko, Evgeny V, Rossokhin, Alexey V, Skrebitsky, Vladimir G

“…Earlier, we have shown a strong inhibitory effect of donepezil on K⁺-current of molluscan neurons (Solntseva et al., Comp Biochem Physiol 144, 319-326, 2007)…”
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