Search Results - "Bujdoso, Raymond"

The emergence of classical BSE from atypical/Nor98 scrapie by Huor, Alvina, Espinosa, Juan Carlos, Vidal, Enric, Cassard, Hervé, Douet, Jean-Yves, Lugan, Séverine, Aron, Naima, Marín-Moreno, Alba, Lorenzo, Patricia, Aguilar-Calvo, Patricia, Badiola, Juan, Bolea, Rosa, Pumarola, Martí, Benestad, Sylvie L., Orge, Leonore, Thackray, Alana M., Bujdoso, Raymond, Torres, Juan-Maria, Andreoletti, Olivier

“…Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and,…”
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Direct Observation of Murine Prion Protein Replication in Vitro by Sang, Jason C, Meisl, Georg, Thackray, Alana M, Hong, Liu, Ponjavic, Aleks, Knowles, Tuomas P. J, Bujdoso, Raymond, Klenerman, David

“…Prions are believed to propagate when an assembly of prion protein (PrP) enters a cell and replicates to produce two or more fibrils, leading to an exponential…”
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Emergence of multiple prion strains from single isolates of ovine scrapie by THACKRAY, Alana M, HOPKINS, Lee, LOCKEY, Richard, SPIROPOULOS, John, BUJDOSO, Raymond

“…The infectious agent associated with prion diseases such as ovine scrapie shows strain diversity. Ovine prion strains have typically been identified by their…”
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Molecular and Transmission Characteristics of Primary-Passaged Ovine Scrapie Isolates in Conventional and Ovine PrP Transgenic Mice by THACKRAY, Alana M, HOPKINS, Lee, SPIROPOULOS, John, BUJDOSO, Raymond

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Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay by Thackray, Alana M, Hopkins, Lee, Bujdoso, Raymond

“…PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates…”
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The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity [version 1; peer review: 2 approved] by Thackray, Alana M, Andréoletti, Olivier, Bujdoso, Raymond

“…Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed…”
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Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage by Beck, Katy E, Thorne, Leigh, Lockey, Richard, Vickery, Christopher M, Terry, Linda A, Bujdoso, Raymond, Spiropoulos, John

“…According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can…”
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Mouse-Adapted Ovine Scrapie Prion Strains Are Characterized by Different Conformers of PrPSc by THACKRAY, Alana M, HOPKINS, Lee, KLEIN, Michael A, BUJDOSO, Raymond

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Accelerated Prion Disease in the Absence of Interleukin-10 by THACKRAY, Alana M, MCKENZIE, Andrew N, KLEIN, Michael A, LAUDER, Angus, BUJDOSO, Raymond

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Chronic Subclinical Prion Disease Induced by Low-Dose Inoculum by Thackray, Alana M, Klein, Michael A, Aguzzi, Adriano, Bujdoso, Raymond

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Genetic vaccination with Flt3-L and GM-CSF as adjuvants： Enhancement of cellular and humoral immune responses that results in protective immunity in a murine model of hepatitis C virus infection by Encke, Jens, Bernardin, Jomo, Geib, Jasmin, Barbakadze, Gocha, Bujdoso, Raymond, Stremmel, Wolfgang

“…AIM： To investigate whether transfection of plasmid DNA encoding these cytokines enhances both humoral and cellular immune responses to hepatitis C virus （HCV）…”
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Alteration of B-Cell Subsets Enhances Neuroinvasion in Mouse Scrapie Infection by von Poser-Klein, Christine, Flechsig, Eckhard, Hoffmann, Tanja, Schwarz, Petra, Harms, Harry, Bujdoso, Raymond, Aguzzi, Adriano, Klein, Michael A

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Subclinical Prion Disease Induced by Oral Inoculation by Thackray, Alana M, Klein, Michael A, Bujdoso, Raymond

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PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency by Thackray, Alana M., Bujdoso, Raymond

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Elevated PrPC Expression Predisposes to Increased HSV-1 Pathogenicity by Thackray, Alana M, Bujdoso, Raymond

“…PrPC is a ubiquitously expressed glycophos-phatidylinositol-linked cell-surface glycoprotein found primarily in neural tissue. Although its normal function has…”
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A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila by Thackray, Alana, Andréoletti, Olivier, Spiropoulos, John, Bujdoso, Raymond

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Mammalian prion propagation in PrP transgenic Drosophila by Thackray, Alana, Andréoletti, Olivier, Bujdoso, Raymond

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Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein by Thackray, Alana M, Madec, Jean-Yves, Wong, Edmond, Morgan-Warren, Robert, Brown, David R, Baron, Thierry, Bujdoso, Raymond

“…Prion-related protein (PrP) is a glycosylphosphatidylinositol-linked cell-surface protein expressed by a wide variety of cells, including those of the nervous…”
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A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila by Thackray, Alana M., Andréoletti, Olivier, Spiropoulos, John, Bujdoso, Raymond

“…Prions are transmissible protein pathogens most reliably detected by a bioassay in a suitable host, typically mice. However, the mouse bioassay is slow and…”
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Prion disease modelled in Drosophila by Bujdoso, Raymond, Smith, Andrew, Fleck, Oliver, Spiropoulos, John, Andréoletti, Olivier, Thackray, Alana M.

“…Prion diseases are fatal neurodegenerative conditions of humans and various vertebrate species that are transmissible between individuals of the same or…”
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