Search Results - "Buist, H."

Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: Alternative approaches by Buist, H.E., Devito, S., Goldbohm, R.A., Stierum, R.H., Venhorst, J., Kroese, E.D.

“…•Amine-based post-combustion carbon capture may generate nitrosamines and nitramines.•Predictive models will save animals and allow safety testing to keep up…”
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Evaluation of inhalation TTC values with the database RepDose by Escher, S.E., Tluczkiewicz, I., Batke, M., Bitsch, A., Melber, C., Kroese, E.D., Buist, H.E., Mangelsdorf, I.

“…The thresholds of toxicological concern (TTCs) define limit values for substances of unknown toxicity below which dietary intake is considered to be of no…”
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Improvement of the Cramer classification for oral exposure using the database TTC RepDose – A strategy description by Tluczkiewicz, I., Buist, H.E., Martin, M.T., Mangelsdorf, I., Escher, S.E.

“…► Improvement of Cramer classification of the TTC concept by using the TTC RepDose DB. ► Strategy for better discrimination of Cramer classes 1–3 is developed…”
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Fatty acid desaturases: selecting the dehydrogenation channel by Buist, Peter H

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Revealing the Catalytic Potential of an Acyl-ACP Desaturase: Tandem Selective Oxidation of Saturated Fatty Acids by Whittle, Edward J., Tremblay, Amy E., Buist, Peter H., Shanklin, John

“…It is estimated that plants contain thousands of fatty acid structures, many of which arise by the action of membrane-bound desaturases and desaturase-like…”
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Topological Study of Mechanistic Diversity in Conjugated Fatty Acid Biosynthesis by Bhar, Palash, Reed, Darwin W., Covello, Patrick S., Buist, Peter H.

“…Variations on an oxidative theme: The precision with which FAD2‐type desaturases carry out CH activation reactions on flexible lipidic substrates is…”
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Characterization of the Regiochemistry and Cryptoregiochemistry of a Caenorhabditis elegans Fatty Acid Desaturase (FAT-1) Expressed in Saccharomyces cerevisiae by Meesapyodsuk, Dauenpen, Reed, Darwin W, Savile, Christopher K, Buist, Peter H, Ambrose, Stephen J, Covello, Patrick S

“…To characterize the fatty acid desaturase produced by the fat-1 gene from the nematode Caenorhabditis elegans, the functional expression of this enzyme was…”
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Castor Stearoyl-ACP Desaturase Can Synthesize a Vicinal Diol by Dioxygenase Chemistry by Whittle, Edward J, Cai, Yuanheng, Keereetaweep, Jantana, Chai, Jin, Buist, Peter H, Shanklin, John

“…In previous work, we identified a triple mutant of the castor ( ) stearoyl-Acyl Carrier Protein desaturase (T117R/G188L/D280K) that, in addition to introducing…”
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Configurational Analysis of Cyclopropyl Fatty Acids Isolated from Escherichia coli by Stuart, Laura J, Buck, James P, Tremblay, Amy E, Buist, Peter H

“…The absolute configuration of methyl lactobacillate and its 9,10 homologue, both isolated from Escherichia coli B−ATCC 11303, was found to be 11R,12S and…”
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Derivation of the minimal magnitude of the Critical Effect Size for continuous toxicological parameters from within-animal variation in control group data by Buist, H.E., von Bölcsházy, G. Frhr, Dammann, M., Telman, J., Rennen, M.A.J.

“…Assuming that temporal fluctuations in physiological parameters (e.g. haematology, biochemistry) in individual healthy non-exposed animals are non-adverse, the…”
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Fatty acid desaturation: variations on an oxidative theme by Behrouzian, Behnaz, Buist, Peter H

“…Significant progress in our understanding of the mechanism of fatty acid desaturation has been achieved. The site of initial oxidation has been determined for…”
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Borderline nuclear change, high-grade dyskaryosis not excluded: current concepts and impact on clinical practice by Soo Hoo, S., Patel, A., Buist, H., Galaal, K., Hemming, J. D., Naik, R.

“…S. S. Hoo, A. Patel, H. Buist, K. Galaal, J. D. Hemming and R. Naik Borderline nuclear change, high‐grade dyskaryosis not excluded: current concepts and impact…”
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The absolute configuration of methyl dihydrosterculate: an unusual phytofatty acid isolated from the seed oil of Litchi chinensis by Stuart, Laura J, Buist, Peter H

“…Graphic The absolute configuration of methyl dihydrosterculate isolated from the seed oil of Litchi chinensis was determined to be (9 R,10 S) by correlation of…”
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WITHDRAWN: Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: an alternative approach by Buist, H E, Bausch-Goldbohm, R A, Devito, S, Venhorst, J, Stierum, R H, Kroese, E D

“…This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier…”
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Mechanism of fatty acid desaturation: a bioorganic perspective by Behrouzian, B., Buist, P.H.

“…The desaturation of long chain fatty acids is a ubiquitous transformation which plays a critical role in the biosynthesis of lipids. Of particular interest to…”
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Commentary on F.E. Gomez et al., “Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes” by Buist, Peter H.

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Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange by Shields, Samuel, Buist, Peter, Manthorpe, Jeffrey

“…The total synthesis of isotopically labelled (9R,10S)-dihydro­sterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon…”
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Exotic biomodification of fatty acids by Buist, Peter H

“…Many biotransformations of mid- to long chain fatty acyl derivatives are intrinsically interesting because of their high selectivity and novel mechanisms…”
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Mechanistic Study of an Improbable Reaction:  Alkene Dehydrogenation by the Δ12 Acetylenase of Crepis alpina by REED, Darwin W., POLICHUK, Devin R., BUIST, Peter H., AMBROSE, Stephen J., SASATA, Robert J., SAVILE, Christopher K., ROSS, Andrew R. S., COVELLO, Patrick S.

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Exploring the hydroxylation-dehydrogenation connection: novel catalytic activity of castor stearoyl-ACP Delta(9) desaturase by Behrouzian, Behnaz, Savile, Christopher K, Dawson, Brian, Buist, Peter H, Shanklin, John

“…The novel product profile obtained by incubating chiral fluorinated substrate analogues with castor stearoyl-ACP Delta(9) desaturase has been rationalized…”
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