Search Results - "Buil, Maria Antonia"

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Esteve, Cristina, Ferrer, Manel, Forns, Pilar, Gómez, Elena, González, Jacob, Lozoya, Estrella, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for…”
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Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure–Activity Relationships by Gràcia, Jordi, Buil, Maria Antonia, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Gavaldà, Amadeu, Hernández, Begoña, Segarra, Victor, Lehner, Martin D, Moreno, Imma, Pagès, Lluís, Roberts, Richard S, Serrat, Jordi, Sevilla, Sara, Taltavull, Joan, Andrés, Miriam, Cabedo, Judit, Vilella, Dolors, Calama, Elena, Carcasona, Carla, Miralpeix, Montserrat

“…Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl…”
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Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists by Buil, Maria Antonia, Calbet, Marta, Castillo, Marcos, Castro, Jordi, Esteve, Cristina, Ferrer, Manel, Forns, Pilar, González, Jacob, López, Sara, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…Monocyclic and bicyclic ring systems were investigated as the “core” section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists…”
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2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castillo, Marcos, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Esteve, Cristina, Gómez, Elena, González, Jacob, Mir, Marta, Petit, Silvia, Roberts, Richard S., Vidal, Bernat, Vidal, Laura, Vilaseca, Pere, Zanuy, Miriam

“…A knowledge-based design strategy led to the discovery of several new series of potent and orally bioavailable CRTh2 antagonists where a bicyclic…”
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2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Domènech, Teresa, Eichhorn, Peter, Ferrer, Manel, Gómez, Elena, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR…”
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Discovery of novel quaternary ammonium derivatives of (3 R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists by Prat, Maria, Buil, María Antonia, Fernández, Maria Dolors, Castro, Jordi, Monleón, Juan Manuel, Tort, Laia, Casals, Gaspar, Ferrer, Manuel, Huerta, Josep Maria, Espinosa, Sònia, López, Manuel, Segarra, Victor, Gavaldà, Amadeu, Miralpeix, Montserrat, Ramos, Israel, Vilella, Dolors, González, Marisa, Córdoba, Mònica, Cárdenas, Alvaro, Antón, Francisca, Beleta, Jorge, Ryder, Hamish

“…Novel quaternary ammonium derivatives of N, N-disubstituted (3 R)-quinuclidinyl carbamates have been identified as potent M 3 muscarinic antagonists with long…”
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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists by Prat, Maria, Buil, María Antonia, Fernández, Maria Dolors, Tort, Laia, Monleón, Juan Manuel, Casals, Gaspar, Ferrer, Manuel, Castro, Jordi, Gavaldà, Amadeu, Miralpeix, Montserrat, Ramos, Israel, Vilella, Dolors, Huerta, Josep Maria, Espinosa, Sònia, Hernández, Begoña, Segarra, Victor, Córdoba, Mònica

“…Novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides have been identified as potent M3 muscarinic antagonists with a long duration of action in…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists by Andrés, Miriam, Buil, Maria Antonia, Calbet, Marta, Casado, Oscar, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Ferrer, Manel, Forns, Pilar, Moreno, Imma, Petit, Silvia, Roberts, Richard S.

“…Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed…”
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