Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system

Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system

The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity of sensitivity...

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Bibliographic Details
Published in:Journal of Chromatography A Vol. 771; no. 1; pp. 119 - 125
Main Authors: Tiller, P.R., Cunniff, J., Land, A.P., Schwartz, J., Jardine, I., Wakefield, M., Lopez, L., Newton, J.F., Burton, R.D., Folk, B.M., Buhrman, D.L., Price, P., Wu, D.
Format: Journal Article Conference Proceeding
Language:English
Published: Amsterdam Elsevier B.V 30-05-1997
Elsevier
Subjects:
Analysis
Biological and medical sciences
Calibration
Chromatography, Liquid - methods
Detection, LC
Gas Chromatography-Mass Spectrometry - methods
General pharmacology
Humans
Hydrocortisone - blood
Liquid chromatography-mass spectrometry
Mass Spectrometry - methods
Medical sciences
Pharmacology. Drug treatments
Reproducibility of Results
Sensitivity and Specificity
SR 27417
Steroids
Testosterone - blood
Thiazoles - analysis
Detection, LC
SR 27417
Liquid chromatography-mass spectrometry
Steroids
Trace analysis
Human
Steroid
Corticosteroid
Biological fluid
Chemical analysis
Coupled method
Thiazole derivatives
Benzene derivatives
HPLC chromatography
Blood
Blood plasma
Pyridine derivatives
Mass spectrometry MS/MS
Quantitative analysis
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Description
Summary:The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity of sensitivity of LC-MS-MS to quantitate trace level components within complex matrices, in particular human plasma. One assay undergoes a validation procedure and demonstrates the utility of this new technology for drug quantitation within a regulated environment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9673
DOI:10.1016/S0021-9673(97)00147-7