Search Results - "Buhrlage, Sara J"

Akkermansia muciniphila phospholipid induces homeostatic immune responses by Bae, Munhyung, Cassilly, Chelsi D., Liu, Xiaoxi, Park, Sung-Moo, Tusi, Betsabeh Khoramian, Chen, Xiangjun, Kwon, Jaeyoung, Filipčík, Pavel, Bolze, Andrew S., Liu, Zehua, Vlamakis, Hera, Graham, Daniel B., Buhrlage, Sara J., Xavier, Ramnik J., Clardy, Jon

“…Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these…”
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry by Ritorto, Maria Stella, Ewan, Richard, Perez-Oliva, Ana B., Knebel, Axel, Buhrlage, Sara J., Wightman, Melanie, Kelly, Sharon M., Wood, Nicola T., Virdee, Satpal, Gray, Nathanael S., Morrice, Nicholas A., Alessi, Dario R., Trost, Matthias

“…Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have…”
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A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia by Yang, Guang, Zhou, Yangsheng, Liu, Xia, Xu, Lian, Cao, Yang, Manning, Robert J., Patterson, Christopher J., Buhrlage, Sara J., Gray, Nathanael, Tai, Yu-Tzu, Anderson, Kenneth C., Hunter, Zachary R., Treon, Steven P.

“…Myeloid differentiation factor 88 (MYD88) L265P somatic mutation is highly prevalent in Waldenström macroglobulinemia (WM) and supports malignant growth…”
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Inhibition of USP10 induces degradation of oncogenic FLT3 by Weisberg, Ellen L, Schauer, Nathan J, Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C, Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M, Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S, Griffin, James D, Buhrlage, Sara J

“…An inhibitor of the deubiquitinase (DUB) USP10 regulates the degradation of oncogenic FLT3, thus defining USP10 as a DUB for FLT3 and providing a therapeutic…”
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Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells by Mistry, Helena, Hsieh, Grace, Buhrlage, Sara J, Huang, Min, Park, Eunmi, Cuny, Gregory D, Galinsky, Ilene, Stone, Richard M, Gray, Nathanael S, D'Andrea, Alan D, Parmar, Kalindi

“…Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the…”
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HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib by Yang, Guang, Buhrlage, Sara J., Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G., Patterson, Christopher J., Brown, Jennifer R., Castillo, Jorge J., Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R., Gray, Nathanael, Treon, Steven P.

“…Activating mutations in MYD88 are present in ∼95% of patients with Waldenström macroglobulinemia (WM), as well as other B-cell malignancies including activated…”
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Accelerating inhibitor discovery for deubiquitinating enzymes by Chan, Wai Cheung, Liu, Xiaoxi, Magin, Robert S., Girardi, Nicholas M., Ficarro, Scott B., Hu, Wanyi, Tarazona Guzman, Maria I., Starnbach, Cara A., Felix, Alejandra, Adelmant, Guillaume, Varca, Anthony C., Hu, Bin, Bratt, Ariana S., DaSilva, Ethan, Schauer, Nathan J., Jaen Maisonet, Isabella, Dolen, Emma K., Ayala, Anthony X., Marto, Jarrod A., Buhrlage, Sara J.

“…Deubiquitinating enzymes (DUBs) are an emerging drug target class of ~100 proteases that cleave ubiquitin from protein substrates to regulate many cellular…”
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Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes by Doherty, Laura M, Mills, Caitlin E, Boswell, Sarah A, Liu, Xiaoxi, Hoyt, Charles Tapley, Gyori, Benjamin, Buhrlage, Sara J, Sorger, Peter K

“…Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove ubiquitin conjugates from proteins, thereby regulating…”
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Strategies for Competitive Activity‐Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization by Zhu, He, Sharafi, Mona, Teh, Wei Pin, Bratt, Ariana S., Buhrlage, Sara J., Marto, Jarrod A.

“…Since its introduction by Cravatt and colleagues in 1999, activity‐based protein profiling (ABPP) has become widely utilized throughout academia, government,…”
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Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases by Banerjee, Sourav, Buhrlage, Sara J, Huang, Hai-Tsang, Deng, Xianming, Zhou, Wenjun, Wang, Jinhua, Traynor, Ryan, Prescott, Alan R, Alessi, Dario R, Gray, Nathanael S

“…The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1)…”
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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability by Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen

“…Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in…”
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Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay by Varca, Anthony C., Casalena, Dominick, Auld, Douglas, Buhrlage, Sara J.

“…Identification of selective deubiquitinase (DUB) inhibitors is critical for probe development to further understand and explore DUB biological function. Here,…”
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Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma by Matthews, Julie Marie, Bhatt, Shruti, Patricelli, Matthew P., Nomanbhoy, Tyzoon K., Jiang, Xiaoyu, Natkunam, Yasodha, Gentles, Andrew J., Martinez, Ezequiel, Zhu, Daxing, Chapman, Jennifer Rose, Cortizas, Elena, Shyam, Ragini, Chinichian, Shideh, Advani, Ranjana, Tan, Li, Zhang, Jianming, Choi, Hwan Geun, Tibshirani, Robert, Buhrlage, Sara J., Gratzinger, Dita, Verdun, Ramiro, Gray, Nathanael S., Lossos, Izidore S.

“…Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, yet 40% to 50% of patients will eventually succumb to their disease,…”
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Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors by Schauer, Nathan J, Magin, Robert S, Liu, Xiaoxi, Doherty, Laura M, Buhrlage, Sara J

“…Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate ubiquitination dynamics. Since their discovery, genetic and functional studies…”
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Repurposing of Kinase Inhibitors for Treatment of COVID-19 by Weisberg, Ellen, Parent, Alexander, Yang, Priscilla L., Sattler, Martin, Liu, Qingsong, Liu, Qingwang, Wang, Jinhua, Meng, Chengcheng, Buhrlage, Sara J., Gray, Nathanael, Griffin, James D.

“…The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for…”
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Proteomic approaches to study ubiquitinomics by Sahu, Indrajit, Zhu, He, Buhrlage, Sara J., Marto, Jarrod A.

“…As originally described some 40 years ago, protein ubiquitination was thought to serve primarily as a static mark for protein degradation. In the ensuing…”
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development by Donovan, Katherine A., Ferguson, Fleur M., Bushman, Jonathan W., Eleuteri, Nicholas A., Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D., Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P., Ghobrial, Irene M., Ma, Michelle W., Che, Jianwei, Buhrlage, Sara J., Sim, Taebo, Gray, Nathanael S., Fischer, Eric S.

“…Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug…”
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Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors by Buhrlage, Sara J, Bates, Caleb A, Rowe, Steven P, Minter, Aaron R, Brennan, Brian B, Majmudar, Chinmay Y, Wemmer, David E, Al-Hashimi, Hashim, Mapp, Anna K

“…Small molecules that reconstitute the binding mode(s) of a protein and in doing so elicit a programmed functional response offer considerable advantages in the…”
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Crystal structure of human IRAK1 by Wang, Li, Qiao, Qi, Ferrao, Ryan, Shen, Chen, Hatcher, John M., Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao

“…Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating innate immune responses against…”
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DUB to the rescue by Teh, Wei Pin, Zhu, He, Marto, Jarrod A., Buhrlage, Sara J.

“…Henning et al. (2022) report development of a novel class of agents, bivalent deubiquitinase (DUB)-targeting chimeras (DUBTACs), that can selectively stabilize…”
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