Search Results - "Buhles, William C."

Compassionate use: a story of ethics and science in the development of a new drug by Buhles, William C

“…This history chronicles the unusual development of the antiviral drug ganciclovir. The first compound with activity against human cytomegalovirus (CMV),…”
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Early Treatment with Ganciclovir to Prevent Cytomegalovirus Disease after Allogeneic Bone Marrow Transplantation by Goodrich, James M, Mori, Motomi, Gleaves, Curt A, Du Mond, Charles, Cays, Monica, Ebeling, Darlene F, Buhles, William C, DeArmond, Bernadette, Meyers, Joel D

“…CYTOMEGALOVIRUS (CMV) infection remains a formidable barrier to allogeneic bone marrow transplantation and continues to cause morbidity and mortality among…”
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High dose oral ganciclovir treatment for cytomegalovirus retinitis by Lalezari, Jacob P., Friedberg, Dorothy N., Bissett, Jack, Giordano, Michael F., Hardy, W.David, Drew, W.Lawrence, Hubbard, Larry D., Buhles, William C., Stempien, Mary Jean, Georgiou, Panos, Jung, Donald T., Robinson, Charles A.

“…Background: The oral formulation of ganciclovir is approved at a dose of 3.0 g/day for maintenance treatment of cytomegalovirus (CMV) retinitis following an…”
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Application of immunologic methods in clinical trials by Buhles, William C

“…Immunologic effects of a new pharmaceutical molecule are often studied by in vitro immune assays and in laboratory animal models. However, immunologic activity…”
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Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients : results of a placebo-controlled, double-blind trial by WINSTON, D. J, HO, W. G, BARTONI, K, DU MOND, C, EBELING, D. F, BUHLES, W. C, CHAMPLIN, R. E

“…To evaluate the efficacy and safety of ganciclovir for prevention of cytomegalovirus (CMV) infection and disease. A randomized, placebo-controlled,…”
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Increased Bone Marrow Production of Granulocytes and Mononuclear Phagocytes Induced by Mycobacterial Adjuvants: Improved Recovery of Leukopoiesis in Mice After Cyclophosphamide Treatment by Buhles, Jr, W C, Shifrine, M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Prevalence of Resistance in Patients Receiving Ganciclovir for Serious Cytomegalovirus Infection by Drew, W. Lawrence, Miner, Richard C., Busch, David F., Follansbee, Stephen E., Gullett, John, Mehalko, Steven G., Gordon, Shelly M., Owen, William F., Matthews, Thomas R., Buhles, William C., DeArmond, Bernadette

“…Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the development of drug-resistant virus…”
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Clinical Pharmacokinetics of Ganciclovir in Patients with Normal and Impaired Renal Function by Sommadossi, Jean-Pierre, Rae Bevan, Teck Ling, Lee, Frank, Barbara Mastre, Melvin D. Chaplin, Clinton Nerenberg, Stuart Koretz, William C. Buhles, Jr

“…The pharmacokinetics of ganciclovir was evaluated in 21 patients with life- or sight-threatening cytomegalovirus infections. Thirteen patients had normal renal…”
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Ganciclovir Treatment of Serious Cytomegalovirus Infection in Heart and Heart-Lung Transplant Recipients by Keay, Susan, Petersen, Eskild, Timothy Icenogle, Barry J. Zeluff, Tobias Samo, David Busch, Cheryl L. Newman, William C. Buhles, Jr, Merigan, Thomas C.

“…Experience with ganciclovir treatment of life- or sight-threatening cytomegalovirus (CMV) infections in 22 heart and heart-lung transplant recipients at six…”
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Preliminary report: effects of interleukin-1 on platelet counts by Tewari, A, Buhles, Jr, W C, Starnes, Jr, H F

“…Recombinant human interleukin-1 beta was given in 5 daily intravenous infusions to ten patients with metastatic malignant disorders as part of an…”
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Isolation of Rickettsia rickettsi in Primary Bone Marrow Cell and Circulating Monocyte Cultures Derived from Experimentally Infected Guinea Pigs by Buhles, Jr, W C, Huxsoll, D L, Elisberg, B L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia by Nemunaitis, J, Appelbaum, FR, Lilleby, K, Buhles, WC, Rosenfeld, C, Zeigler, ZR, Shadduck, RK, Singer, JW, Meyer, W, Buckner, CD

“…A phase I trial was conducted with recombinant human interleukin-1 beta (rhIL-1 beta) in patients undergoing autologous bone marrow (BM) transplantation for…”
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Effect of food on the relative bioavailability of oral ganciclovir by Lavelle, J, Follansbee, S, Trapnell, C B, Buhles, W C, Griffy, K G, Jung, D, Dorr, A, Connor, J

“…The steady-state pharmacokinetics of oral ganciclovir in the fasting versus fed state were studied in 20 patients infected with human immunodeficiency virus…”
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GM-CSF with ganciclovir for the treatment of CMV retinitis in AIDS by Grossberg, H S, Bonnem, E M, Buhles, Jr, W C

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Oral ganciclovir for cytomegalovirus infections by Follansbee, S E, Stempien, M J, Buhles, W C

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Letters to the Editor by Shifrine, Moshe, Buhles, William C.

“…Abstract Sir: Two recent publications by Fidler, Brodey, and Bech-Nielsen (1, 2) (one of them published in the J. of Immunology) address themselves to the…”
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Phase I Study of Recombinant Interleukin-1β in Patients Undergoing Autologous Bone Marrow Transplant for Acute Myelogenous Leukemia by Nemunaitis, John, Appelbaum, Frederick R., Lilleby, Kathy, Buhles, William C., Rosenfeld, Craig, Zeigler, Zella R., Shadduck, Richard K., Singer, Jack W., Meyer, Wally, Buckner, C.Dean

“…A phase I trial was conducted with recombinant human interleukin-1β (rhIL-1β) in patients undergoing autologous bone marrow (BM) transplantation for acute…”
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Tropical Canine Pancytopenia: Clinical, Hematologic, and Serologic Response of Dogs to Ehrlichia canis Infection, Tetracycline Therapy, and Challenge Inoculation by Buhles, William C., Huxsoll, David L., Ristic, Miodrag

“…For further elucidation of the pathogenesis of tropical canine pancytopenia (TCP), 14 German shepherd dogs were evaluated following infection with Ehrlichia…”
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Letters to the Editor by Shifrine, Moshe, Buhles, William C., Jr

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Adjuvant Protection against Bacterial Infection in Granulocytopenic Mice by Buhles, William C., Shifrine, Moshe

“…The hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased…”
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