Search Results - "Buhard, O"

Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency by Cohen, R., Buhard, O., Cervera, P., Hain, E., Dumont, S., Bardier, A., Bachet, J.-B., Gornet, J.-M., Lopez-Trabada, D., Dumont, S., Kaci, R., Bertheau, P., Renaud, F., Bibeau, F., Parc, Y., Vernerey, D., Duval, A., Svrcek, M., André, Thierry

“…Patients treated with chemotherapy for microsatellite unstable (MSI) and/or mismatch repair deficient (dMMR) cancer metastatic colorectal cancer (mCRC) exhibit…”
Get full text

Prediction of response to immune checkpoint blockade in patients with metastatic colorectal cancer with microsatellite instability by Ratovomanana, T., Nicolle, R., Cohen, R., Diehl, A., Siret, A., Letourneur, Q., Buhard, O., Perrier, A., Guillerm, E., Coulet, F., Cervera, P., Benusiglio, P., Labrèche, K., Colle, R., Collura, A., Despras, E., Le Rouzic, P., Renaud, F., Cros, J., Alentorn, A., Touat, M., Ayadi, M., Bourgoin, P., Prunier, C., Tournigand, C., Fouchardière, C. de la, Tougeron, D., Jonchère, V., Bennouna, J., de Reynies, A., Fléjou, J.-F., Svrcek, M., André, T., Duval, A.

“…Mismatch repair-deficient (dMMR) tumors displaying microsatellite instability (MSI) represent a paradigm for the success of immune checkpoint inhibitor…”
Get full text

Assessment of local clinical practice for testing of mismatch repair deficiency in metastatic colorectal cancer: The need for new diagnostic guidelines prior to immunotherapy by Cohen, R, Hain, E, Buhard, O, Guilloux, A, Bardier, A, Kaci, R, Bertheau, P, Renaud, F, Bibeau, F, Fléjou, J-F, André, T, Svrcek, M, Duval, A

Get full text

Tumours with loss of MSH6 expression are MSI-H when screened with a pentaplex of five mononucleotide repeats by You, J-F, Buhard, O, Ligtenberg, M J L, Kets, C M, Niessen, R C, Hofstra, R M W, Wagner, A, Dinjens, W N M, Colas, C, Lascols, O, Collura, A, Flejou, J-F, Duval, A, Hamelin, R

“…Background: Microsatellite instability (MSI) is commonly screened using a panel of two mononucleotide and three dinucleotide repeats as recommended by a…”
Get full text

TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription by CUILLIERE-DARTIGUES, P, EL-BCHIRI, J, KRIMI, A, BUHARD, O, FONTANGES, P, FLEJOU, J.-F, HAMELIN, R, DUVAL, A

“…TCF-4 is the main effector of the Wnt/Wingless signalling pathway. As with other TCF/LEF factors, numerous alternative splicings at its 3' end affect its…”
Get full text

Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract by MONGIAT-ARTUS, P, MIQUEL, C, PRAZ, F, VAN DER AA, M, BUHARD, O, HAMELIN, R, SOLIMAN, H, BANGMA, C, JANIN, A, TEILLAC, P, VAN DER KWAST, T

“…A subset of upper urinary tract urothelial cell carcinomas (UUC), arising sporadically or as a manifestation of hereditary non-polyposis colorectal cancer,…”
Get full text

No Evidence for Microsatellite Instability in Immunodeficiency‐Related Skin Cancers by Borie, C., Euvrard, S., Vérola, O., Buhard, O., Barete, S., Molina, J. M., Kanitakis, J., Kérob, D., Lebbé, C., Duval, A.

Get full text

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers by Svrcek, Magali, Buhard, Olivier, Colas, Chrystelle, Coulet, Florence, Dumont, Sylvie, Massaoudi, Illiasse, Lamri, Amel, Hamelin, Richard, Cosnes, Jacques, Oliveira, Carla, Seruca, Raquel, Gaub, Marie-Pierre, Legrain, Michèle, Collura, Ada, Lascols, Olivier, Tiret, Emmanuel, Fléjou, Jean-François, Duval, Alex

“…O(6)-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O(6)-guanine. Known as methylation tolerance, selection for mismatch repair…”
Get more information

537PAssessment of local clinical practice for testing of mismatch repair deficiency in metastatic colorectal cancer: The need for new diagnostic guidelines prior to immunotherapy by Cohen, R, Hain, E, Buhard, O, Guilloux, A, Bardier, A, Kaci, R, Bertheau, P, Renaud, F, Bibeau, F, Fléjou, J-F, André, T, Svrcek, M, Duval, A

Get full text

Multipopulation Analysis of Polymorphisms in Five Mononucleotide Repeats Used to Determine the Microsatellite Instability Status of Human Tumors by BUHARD, Olivier, CATTANEO, Francesca, FU WONG, Yick, SO FAN YIM, FRIEDMAN, Eitan, FLEJOU, Jean-Francois, DUVAL, Alex, HAMELIN, Richard

“…Human gastrointestinal tumors with inactivated DNA mismatch repair system (microsatellite instability [MSI] tumors) have distinct molecular and…”
Get full text

Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis by Buhard, Olivier, Suraweera, Nirosha, Lectard, Aude, Duval, Alex, Hamelin, Richard

“…Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to…”
Get full text

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers by El-Bchiri, Jamila, Buhard, Olivier, Penard-Lacronique, Virginie, Thomas, Gilles, Hamelin, Richard, Duval, Alex

“…The nonsense-mediated decay (NMD) system normally targets mRNAs with premature termination codons (PTCs) for rapid degradation. We investigated for a putative…”
Get full text

Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers by Wong, Yick Fu, Cheung, Tak Hong, Lo, Keith Wing Kit, Yim, So Fan, Chan, Loucia Kit Yin, Buhard, Olivier, Duval, Alex, Chung, Tony Kwok Hung, Hamelin, Richard

“…The aim of this study was to find the optimal set of microsatellite markers for diagnosis of the microsatellite instability (MSI) phenotype in endometrial…”
Get full text

Mononucleotide repeats BAT‐26 and BAT‐25 accurately detect MSI‐H tumors and predict tumor content: Implications for population screening by Brennetot, Caroline, Buhard, Olivier, Jourdan, Florence, Flejou, Jean‐François, Duval, Alex, Hamelin, Richard

“…Tumors with a defective DNA mismatch repair system (MSI‐H tumors) have distinct molecular and clinicopathologic profiles compared with mismatch…”
Get full text

Loss of MGMT expression as a pre-neoplastic event favoring the emergence of MSI colorectal cancers by Svrcek, M., Buhard, O., Dumont, S., Colas, C., Coulet, F., Cosnes, J., Tiret, E., Fléjou, J., Duval, A.

“…Abstract only…”
Get full text

The Mutator Pathway Is a Feature of Immunodeficiency-Related Lymphomas by Duval, Alex, Raphael, Martine, Brennetot, Caroline, Poirel, Helene, Buhard, Olivier, Aubry, Alban, Martin, Antoine, Krimi, Amor, Leblond, Veronique, Gabarre, Jean, Davi, Frederic, Charlotte, Frederic, Berger, Francoise, Gaidano, Gianluca, Capello, Daniela, Canioni, Danielle, Bordessoule, Dominique, Feuillard, Jean, Gaulard, Philippe, Delfau, Marie Helene, Ferlicot, Sophie, Eclache, Virginie, Prevot, Sophie, Guettier, Catherine, Lefevre, Pascale Cornillet, Adotti, Francoise, Hamelin, Richard, Dausset, Jean

“…The mutator phenotype caused by defects in the mismatch repair system is observed in a subset of solid neoplasms characterized by widespread microsatellite…”
Get full text

Infrequent Microsatellite Instability in Urothelial Cell Carcinoma of the Bladder in Young Patients by Mongiat-Artus, Pierre, Miquel, Catherine, van der Aa, Madelon, Buhard, Olivier, Hamelin, Richard, Bangma, Chris, Teillac, Pierre, van der Kwast, Theodorus, Praz, Françoise

“…Defects in the DNA mismatch repair result in microsatellite instability (MSI), which characterise most tumours related to the hereditary non-polyposis…”
Get full text

MICROSATELLITE INSTABILITY AND MUTATION ANALYSIS OF CANDIDATE GENES IN UROTHELIAL CELL by Mongiat Artus, P., Miquel, C., Van der Aa, M., Buhard, O., Hamelin, R., Soliman, H., Bangma, C., Janin, A., Teillac, P., Van der Kwast, T., Praz, F.

Get full text

MSH2 gene dosage mediates azathioprine-induced carcinogenesis in mice by Chalastanis, A., Penard-Lacronique, V., Svrcek, M., Defaweux, Valérie, Antoine, Nadine, Buhard, O., Dumont, S., Fabiani, B., Renault, I., Tubacher, E., Fléjou, J. F., te Riele, H., Duval, A., Muleris, M.

Get full text