Search Results - "Bugter, Jeroen M"

TMEM59 potentiates Wnt signaling by promoting signalosome formation by Gerlach, Jan P., Jordens, Ingrid, Tauriello, Daniele V. F., van ’t Land-Kuper, Ineke, Bugter, Jeroen M., Noordstra, Ivar, van der Kooij, Johanneke, Low, Teck Y., Pimentel-Muiños, Felipe X., Xanthakis, Despina, Fenderico, Nicola, Rabouille, Catherine, Heck, Albert J. R., Egan, David A., Maurice, Madelon M.

“…Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its…”
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Mutations and mechanisms of WNT pathway tumour suppressors in cancer by Bugter, Jeroen M., Fenderico, Nicola, Maurice, Madelon M.

“…Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human cancer. Sustained WNT–β-catenin pathway activation endows cancer…”
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Publisher Correction: Mutations and mechanisms of WNT pathway tumour suppressors in cancer by Bugter, Jeroen M., Fenderico, Nicola, Maurice, Madelon M.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer by Spit, Maureen, Fenderico, Nicola, Jordens, Ingrid, Radaszkiewicz, Tomasz, Lindeboom, Rik GH, Bugter, Jeroen M, Cristobal, Alba, Ootes, Lars, van Osch, Max, Janssen, Eline, Boonekamp, Kim E, Hanakova, Katerina, Potesil, David, Zdrahal, Zbynek, Boj, Sylvia F, Medema, Jan Paul, Bryja, Vitezslav, Koo, Bon‐Kyoung, Vermeulen, Michiel, Maurice, Madelon M

“…Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt…”
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USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer by Reissland, Michaela, Hartmann, Oliver, Tauch, Saskia, Bugter, Jeroen M, Prieto-Garcia, Cristian, Schulte, Clemens, Loebbert, Sinah, Solvie, Daniel, Bitman-Lotan, Eliya, Narain, Ashwin, Jacomin, Anne-Claire, Schuelein-Voelk, Christina, Fuss, Carmina T, Pahor, Nikolett, Ade, Carsten, Buck, Viktoria, Potente, Michael, Li, Vivian, Beliu, Gerti, Wiegering, Armin, Grossmann, Tom, Eilers, Martin, Wolf, Elmar, Maric, Hans, Rosenfeldt, Mathias, Maurice, Madelon M, Dikic, Ivan, Gallant, Peter, Orian, Amir, Diefenbacher, Markus E

“…The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here,…”
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E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors by Bugter, Jeroen M, van Kerkhof, Peter, Jordens, Ingrid, Janssen, Eline, Tran Ngoc Minh, Thi, Iglesias van Montfort, Daniel, Jamieson, Cara, Maurice, Madelon M

“…The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by inducing endocytosis of members of the Frizzled (FZD) family, the primary…”
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Abstract LB301: BRAFV600E drives WNT signalling in colorectal cancer via aberrant DNA methylation by Bouazzaoui, Layla El, Bugter, Jeroen M., Küçükköse, Emre, Verheem, André, Post, Jasmin B., Fenderico, Nicola, Rinkes, Inne H. Borel, Snippert, Hugo J., Maurice, Madelon M., Kranenburg, Onno

“…Objective: The BRAF V600E mutation drives the generation of an aggressive subtype of colorectal cancer (CRC). Although activation of WNT signalling is a…”
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RNF 43 truncations trap CK 1 to drive niche‐independent self‐renewal in cancer by Spit, Maureen, Fenderico, Nicola, Jordens, Ingrid, Radaszkiewicz, Tomasz, Lindeboom, Rik GH, Bugter, Jeroen M, Cristobal, Alba, Ootes, Lars, van Osch, Max, Janssen, Eline, Boonekamp, Kim E, Hanakova, Katerina, Potesil, David, Zdrahal, Zbynek, Boj, Sylvia F, Medema, Jan Paul, Bryja, Vitezslav, Koo, Bon‐Kyoung, Vermeulen, Michiel, Maurice, Madelon M

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