Search Results - "Bugge, Anne"

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand by Yang, Linda, Chang, Chih-Chuan, Sun, Zhe, Madsen, Dennis, Zhu, Haisun, Padkjær, Søren B, Wu, Xiaoai, Huang, Tao, Hultman, Karin, Paulsen, Sarah J, Wang, Jishu, Bugge, Anne, Frantzen, Jane Boesen, Nørgaard, Per, Jeppesen, Jacob Fuglsbjerg, Yang, Zhiru, Secher, Anna, Chen, Haibin, Li, Xun, John, Linu Mary, Shan, Bing, He, Zhenhua, Gao, Xiang, Su, Jing, Hansen, Kristian T, Yang, Wei, Jørgensen, Sebastian Beck

“…GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor that mediates GDF15's effects via central…”
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Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism by Feng, Dan, Liu, Tao, Sun, Zheng, Bugge, Anne, Mullican, Shannon E, Alenghat, Theresa, Liu, X. Shirley, Lazar, Mitchell A

“…Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the…”
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Measuring respiratory activity of adipocytes and adipose tissues in real time by Bugge, Anne, Dib, Lea, Collins, Sheila

“…The realization that obesity and its associated diseases have become one of modern society's major challenges to the health of the world's population has…”
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LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes[S] by Dib, Lea, Bugge, Anne, Collins, Sheila

“…Liver X receptors (LXRs) are transcription factors known for their role in hepatic cholesterol and lipid metabolism. Though highly expressed in fat, the role…”
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Life-threatening danger assessments of penetrating injuries in Eastern Danish clinical forensic medicine by Jakobsen, Lykke Schrøder, Christensen, Marie Toftdahl, Lundemose, Sissel Banner, Munkholm, Julie, Bugge, Anne Birgitte Dyhre, Lynnerup, Niels, Banner, Jytte

“…Clinical forensic assessments of injuries’ life-threatening danger may have an impact on the legal aftermath following a violent assault. The pursuit of…”
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The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease by Werge, Mikkel Parsberg, McCann, Adrian, Galsgaard, Elisabeth Douglas, Holst, Dorte, Bugge, Anne, Albrechtsen, Nicolai J Wewer, Gluud, Lise Lotte

“…The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately 25% of the global population may have NAFLD. NAFLD is associated…”
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Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients by Monfeuga, Thomas, Norlin, Jenny, Bugge, Anne, Gaalsgaard, Elisabeth D, Prada-Medina, Cesar A, Latta, Markus, Veidal, Sanne S, Petersen, Pia S, Feigh, Michael, Holst, Dorte

“…The metabolic benefits of GLP-1 receptor (GLP-1R) agonists on glycemic and weight control are well established as therapy for type 2 diabetes and obesity…”
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Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation by Bugge, Anne, Mandrup, Susanne

“…The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The…”
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The PPARγ2 A/B-Domain Plays a Gene-Specific Role in Transactivation and Cofactor Recruitment by Bugge, Anne, Grøntved, Lars, Aagaard, Mads M, Borup, Rehannah, Mandrup, Susanne

“…We have previously shown that adenoviral expression of peroxisome proliferator-activated receptors (PPARs) leads to rapid establishment of transcriptionally…”
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HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation by Nebbioso, Angela, Dell'Aversana, Carmela, Bugge, Anne, Sarno, Roberta, Valente, Sergio, Rotili, Dante, Manzo, Fabio, Teti, Diana, Mandrup, Susanne, Ciana, Paolo, Maggi, Adriana, Mai, Antonello, Gronemeyer, Hinrich, Altucci, Lucia

“…Epigenetic deregulation contributes to diseases including cancer, neurodegeneration, osteodystrophy, cardiovascular defects, and obesity. For this reason,…”
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Establishing post mortem criteria for the metabolic syndrome: an autopsy based cross-sectional study by Christensen, Martin Roest, Bugge, Anne, Malik, Mariam Elmegaard, Thomsen, Jørgen Lange, Lynnerup, Niels, Rungby, Jørgen, Banner, Jytte

“…Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an…”
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PPAR agonists, - Could tissue targeting pave the way? by Bugge, Anne, Holst, Dorte

“…Over the last couple of decades, the PPAR family of transcription factors has received much attention from the pharmaceutical industry due to their profound…”
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Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function by Bugge, Anne, Feng, Dan, Everett, Logan J, Briggs, Erika R, Mullican, Shannon E, Wang, Fenfen, Jager, Jennifer, Lazar, Mitchell A

“…The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects are modest and it has been considered to be a secondary regulator of…”
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Targeted metabolomics reveals alterations in one-carbon metabolism in NAFLD patients by Werge, Mikkel, McCann, Adrian, Galsgaard, Elisabeth, Holst, Dorte, Bugge, Anne, Gluud, Lise Lotte

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The nuclear receptor Rev-erbα controls circadian thermogenic plasticity by Gerhart-Hines, Zachary, Feng, Dan, Emmett, Matthew J., Everett, Logan J., Loro, Emanuele, Briggs, Erika R., Bugge, Anne, Hou, Catherine, Ferrara, Christine, Seale, Patrick, Pryma, Daniel A., Khurana, Tejvir S., Lazar, Mitchell A.

“…The nuclear receptor Rev-erbα, a powerful repressor of transcription, is shown to link circadian and thermogenic networks by regulating the function of brown…”
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“Nutrition or no nutrition?”: Chylothorax or leakage of total parenteral nutrition? by Zasada, Inga Alicja, Banner, Jytte, Bugge, Anne

“…Total parenteral nutrition (TPN) using a central line is an invasive and widely used procedure associated with several complications. Pleural effusion…”
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Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs by Christoffersen, Berit Ø., Skyggebjerg, Rikke Bjerring, Bugge, Anne, Kirk, Rikke Kaae, Vestergaard, Bill, Uldam, Henriette Kold, Fels, Johannes Josef, Pyke, Charles, Sensfuss, Ulrich, Sanfridson, Annika, Clausen, Trine Ryberg

“…Background/Objectives Cholecystokinin (CCK) is a regulator of appetite and energy intake in man. The aim of this study was to determine the effect of NN9056, a…”
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Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates by Nyborg, Niels Chresten Berg, Kirk, Rikke Kaae, de Boer, Anne Sietske, Andersen, David Wederkinck, Bugge, Anne, Wulff, Birgitte Schjellerup, Thorup, Inger, Clausen, Trine Ryberg

“…Cholecystokinin (CCK) may potentially be used to treat obesity. However, it is well-known to induce acute pancreatitis and pancreas neoplasia in rodents, but…”
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Cloning and characterization of the porcine gastrin/cholecystokinin type 2 receptor by Bugge, Anne, Jansen, Peter Gildsig, Maria, Leonardo De, Sanni, Samra Joke, Clausen, Trine Ryberg

“…The gastrointestinal hormone cholecystokinin (CCK) regulates digestive processes and satiety in addition to centrally mediated effects on nociception and…”
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FRI-305-Long acting GLP-1/Glucagon co-agonist ameliorates steatosis, inflammation and fibrogenesis in a rodent model of NASH by Norlin, Jenny Egecioglu, Galsgaard, Elisabeth, Bugge, Anne, Hansen, Thomas, Lau, Jesper, Raun, Kirsten, Latta, Markus Robert, Holst, Dorte

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