Search Results - "Bugelski, P"

CNTO 530 : Molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice by BUGELSKI, P. J, CAPOCASALE, R. J, VOLK, A, NESSPOR, T, JAMES, I. E, HUANG, C, MAKROPOULOS, D, MARSHALL, D, FISHER, P. W, LU, J, ACHUTHANANDAM, R, SPINKA-DOMS, T, KWOK, D, GRADEN, D

“…CNTO 530 is a 58 kD antibody Fc domain fusion protein, created using Centocor's MIMETIBODY platform, that contains two EMP1 sequences as a pharmacophore. CNTO…”
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Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock‐in mice by SNYDER, L. A., RUDNICK, K. A., TAWADROS, R., VOLK, A., TAM, S. H., ANDERSON, G. M., BUGELSKI, P. J., YANG, J.

“…Background: Tissue factor (TF) is expressed widely at the subluminal surface of blood vessels and serves as the primary cellular initiator of the extrinsic…”
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Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system by O'Brien, P J, Slaughter, M R, Swain, A, Birmingham, J M, Greenhill, R W, Elcock, F, Bugelski, P J

“…Repeated dosing of acetaminophen (paracetamol) to rats is reported to decrease their sensitivity to its hepatotoxic effects, which are associated with…”
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Maximization of signal derived from cDNA microarrays by Wildsmith, S E, Archer, G E, Winkley, A J, Lane, P W, Bugelski, P J

“…Microarray technology is a powerful tool for generating expression data on a large number of genes simultaneously. However, as for any assay, it must be…”
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Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys by Hart, Timothy K., Cook, Richard M., Zia-Amirhosseini, Parnian, Minthorn, Elisabeth, Sellers, Teresa S., Maleeff, Beverly E., Eustis, Scot, Schwartz, Lester W., Tsui, Ping, Appelbaum, Edward R., Martin, Elise C., Bugelski, Peter J., Herzyk, Danuta J.

“…Background: Allergic respiratory diseases are characterized by large numbers of eosinophils and their reactive products in airways and blood; these are…”
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Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model by BERMAN, Dora M, CABRERA, Over, HORNINGER, Denison, LARK, Michael, DAVIS, Janet E, ALEJANDRO, Rodolfo, BERGGREN, Per-Olof, ZIMMERMAN, Mark, O'NEIL, John J, RICORDI, Camillo, KENYON, Norma S, KENYAN, Norman M, MILLER, Joshua, TAM, Susan H, KHANDEKAR, Vrinda S, PICHA, Kristen M, SODERMAN, Avery R, JORDAN, Robert E, BUGELSKI, Peter J

“…Tissue factor (TF) expression on islets can result in an instant blood-mediated inflammatory reaction (IBMIR) that contributes to early islet loss. We tested…”
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Comparison of adipose tissue changes following administration of rosiglitazone in the dog and rat by Toseland, C. D. N., Campbell, S., Francis, I., Bugelski, P. J., Mehdi, N.

“…Summary Rosiglitazone (BRL‐49653‐C), a thiazolidinedione, is a potent agonist for the nuclear hormone receptor peroxisome proliferator‐activated receptor gamma…”
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A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells by LaBranche, C C, Sauter, M M, Haggarty, B S, Vance, P J, Romano, J, Hart, T K, Bugelski, P J, Marsh, M, Hoxie, J A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Binding of Soluble CD4 Proteins to Human Immunodeficiency Virus Type 1 and Infected Cells Induces Release of Envelope Glycoprotein gp120 by Hart, Timothy K., Kirsh, Richard, Ellens, Harma, Sweet, Raymond W., Lambert, Dennis M., Petteway, Stephen R., Leary, Jeffry, Bugelski, Peter J.

“…Human immunodeficiency virus (HIV) infects cells after binding of the viral envelope glycoprotein gp120 to the cell surface recognition marker CD4. gp120 is…”
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Evaluation of Alamar Blue Reduction for the In Vitro Assay of Hepatocyte Toxicity by Slaughter, M.R, Bugelski, P.J, O'Brien, P.J

“…Alamar Blue (AB) reduction is a promising new in vitro assay which is simple to conduct and amenable to repeated measurements and high-throughput screening;…”
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Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice by HERZYK, Danuta J, GORE, Elizabeth R, POLSKY, Rodd, NADWODNY, Kimberly L, MAIER, Curtis C, LIU, Susan, HART, Timothy K, HARMSEN, Allen G, BUGELSKI, Peter J

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Practical aspects of including functional endpoints in developmental toxicity studies. Case study: immune function in HuCD4 transgenic mice exposed to anti-CD4 MAb in utero by Herzyk, D J, Bugelski, P J, Hart, T K, Wier, P J

“…Keliximab is a human-cynomolgus monkey chimeric (Primatized) monoclonal antibody with specificity for human and chimpanzee CD4. As the preclinical safety…”
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Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies by Bugelski, P J, Herzyk, D J, Rehm, S, Harmsen, A G, Gore, E V, Williams, D M, Maleeff, B E, Badger, A M, Truneh, A, O'Brien, S R, Macia, R A, Wier, P J, Morgan, D G, Hart, T K

“…The preclinical safety assessment of biopharmaceuticals necessitates that studies be conducted in species in which the products are pharmacologically active…”
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Evidence of foam cell and cholesterol crystal formation in macrophages incubated with oxidized LDL by fluorescence and electron microscopy by Klinkner, AM, Waites, CR, Kerns, WD, Bugelski, PJ

“…Macrophage-derived foam cells are a prominent component of developing atherosclerotic lesions. We describe an in vitro model of foam cell formation which…”
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A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology by BUGELSKI, Peter J, ATIF, Uzma, MOLTON, Sarah, TOEG, Ilana, LORD, Peter G, MORGAN, D. Gwyn

“…Recent advances in combinatorial chemistry and high throughput screens for pharmacologic activity have created an increasing demand for in vitro high…”
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ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats by Rabinovici, R, Bugelski, P J, Esser, K M, Hillegass, L M, Vernick, J, Feuerstein, G

“…We recently reported that the combined administration of lipopolysaccharide (LPS) and platelet-activating factor (PAF) in rats, at doses that are completely…”
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Differential Gene Expression in Rats Following Subacute Exposure to the Anticonvulsant Sodium Valproate by Plant, N., Barber, P., Horner, E., Cockburn, C.-L., Gibson, G., Bugelski, P., Lord, P.

“…Sodium valproate (VPA) is clinically employed as an anticonvulsant and, to a lesser extent, as a mood stabilizer. While the incidence of toxicity associated…”
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Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120 by YUNG-KANG FU, HART, T. K, JONAK, Z. L, BUGELSKI, P. J

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Chemometric strategies for normalisation of gene expression data obtained from cDNA microarrays by Wu, W., Wildsmith, S.E., Winkley, A.J., Yallop, R., Elcock, F.J., Bugelski, P.J.

“…DNA microarray technology is emerging as an important method in Functional Genomics. Microarrays enable rapid, large scale gene expression analysis but the…”
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Temporal relation between neutrophil accumulation and myocardial reperfusion injury by Smith, 3rd, E F, Egan, J W, Bugelski, P J, Hillegass, L M, Hill, D E, Griswold, D E

“…Infiltration of polymorphonuclear leukocytes (PMN) is associated with the progression of myocardial infarction and reperfusion injury. However, little is known…”
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