Retinal Sensitivity and Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Glaucoma

Purpose To define the relationship between retinal light sensitivity and peripapillary retinal nerve fiber layer (RNFL) thickness as measured using the Stratus optical coherence tomograph (OCT). Design Prospective study. Methods setting: Institutional. study population: A total of 126 healthy subjec...

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Bibliographic Details
Published in:	American journal of ophthalmology Vol. 144; no. 5; pp. 733 - 740.e1
Main Authors:	Miglior, Stefano, Riva, Ivano, Guareschi, Magda, Di Matteo, Federico, Romanazzi, Filippo, Buffagni, Laura, Rulli, Eliana
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-11-2007 Elsevier Elsevier Limited
Subjects:	Adult Age Aged Biological and medical sciences Female Glaucoma Glaucoma and intraocular pressure Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Light Male Medical sciences Middle Aged Miscellaneous Nerve Fibers - pathology Ocular Hypertension - diagnosis Ocular Hypertension - physiopathology Ophthalmology Optic Disk - pathology Optic Nerve Diseases - diagnosis Optic Nerve Diseases - physiopathology Optics Prospective Studies Regression analysis Retina - physiopathology Retinal Ganglion Cells - pathology Tomography Tomography, Optical Coherence Variables Visual Field Tests Visual Fields Glaucoma Protozoa Optical coherence tomography Retina Layer thickness Eye disease Sensitivity Glaucoma (eye) Ciliata Ophthalmology Nerve fiber Retinal Optical fiber
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Summary:	Purpose To define the relationship between retinal light sensitivity and peripapillary retinal nerve fiber layer (RNFL) thickness as measured using the Stratus optical coherence tomograph (OCT). Design Prospective study. Methods setting: Institutional. study population: A total of 126 healthy subjects, 42 patients with ocular hypertension (OHT) and 64 patients with primary open-angle glaucoma (POAG) were examined by the 24/II program of the Humphrey Field Analyzer (Carl Zeiss Meditec, Inc, Dublin, California, USA), and the Fast RNFL Thickness examination of the OCT. Individual visual field (VF) test scores and peripapillary RNFL thickness measurements were grouped into six topographically corresponding sectors whose mean values were then calculated. One eye per patient was randomly chosen. main outcome measures: The correlations between mean retinal sensitivity (expressed both in decibel and unlogged scales) and RNFL thickness were described with linear and logarithmic regression analyses. Results With reference to all 232 individuals, the equation that best explained the model was logarithmic when using the decibel scale, and either linear or logarithmic when using the unlogged scale. A statistically significant, age-adjusted correlation between function and structure was found in most sectors both using the decibel (logarithmic regression analysis r2 0.24 to 0.61, P < .001), and the unlogged scale ( r2 0.37 to 0.53, P < .001 in both linear and logarithmic regression analyses). Conclusions When using the decibel scale, the logarithmic equation may better explain the function/structure relationship between retinal sensitivity and OCT-measured RNFL thickness along a wide spectrum of glaucoma continuum. These results support the need to combine functional and structural tests in the detection of early glaucoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9394 1879-1891
DOI:	10.1016/j.ajo.2007.06.035