Search Results - "Buerger, Claudia"

Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target by Buerger, Claudia

“…Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in…”
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Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation by Buerger, Claudia, Shirsath, Nitesh, Lang, Victoria, Berard, Alina, Diehl, Sandra, Kaufmann, Roland, Boehncke, Wolf-Henning, Wolf, Peter

“…Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR…”
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Cell Volume Regulation in the Epidermis by Jahn, Magdalena, Rauh, Oliver, Fauth, Torsten, Buerger, Claudia

“…In order to cope with external stressors such as changes in humidity and temperature or irritating substances, the epidermis as the outermost skin layer forms…”
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Localization of Rheb to the endomembrane is critical for its signaling function by Buerger, Claudia, DeVries, Ben, Stambolic, Vuk

“…Rheb, a small GTPase, has emerged as a key molecular switch that directly regulates the activity of the mammalian target of rapamycin (mTOR). Similar to other…”
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mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex by Ferreri, Antonio, Lang, Victoria, Kaufmann, Roland, Buerger, Claudia

“…In the basal, proliferative layer of healthy skin, the mTOR complex 1 (mTORC1) is activated, thus regulating proliferation while preventing differentiation…”
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PI3K/AKT/mTOR Signaling Network in Human Health and Diseases by Omolekan, Tolulope O, Chamcheu, Jean Christopher, Buerger, Claudia, Huang, Shile

“…Transduction of molecular signaling is a fundamental mechanism that allows a living cell to communicate internally with other cells and its environment through…”
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Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels by Trothe, Janina, Ritzmann, Dirk, Lang, Victoria, Scholz, Paul, Pul, Ümit, Kaufmann, Roland, Buerger, Claudia, Ertongur‐Fauth, Torsten

“…The barrier function of the human epidermis is constantly challenged by environmental osmotic fluctuations. Hypotonic stress triggers cell swelling, which is…”
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The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds by Roy, Tithi, Boateng, Samuel T, Uddin, Mohammad B, Banang-Mbeumi, Sergette, Yadav, Rajesh K, Bock, Chelsea R, Folahan, Joy T, Siwe-Noundou, Xavier, Walker, Anthony L, King, Judy A, Buerger, Claudia, Huang, Shile, Chamcheu, Jean Christopher

“…The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated…”
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Peptide Aptamers with Binding Specificity for the Intracellular Domain of the ErbB2 Receptor Interfere with AKT Signaling and Sensitize Breast Cancer Cells to Taxol by Kunz, Christian, Borghouts, Corina, Buerger, Claudia, Groner, Bernd

“…The ErbB2 receptor tyrosine kinase is overexpressed in ∼30% of breast tumor cases and its overexpression correlates with an unfavorable prognosis. A major…”
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Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR by Marshall, Christopher B, Ho, Jason, Buerger, Claudia, Plevin, Michael J, Li, Guang-Yao, Li, Zhihong, Ikura, Mitsuhiko, Stambolic, Vuk

“…Tuberous sclerosis complex 2 (TSC2), whose gene is frequently mutated in tuberous sclerosis, increases the guanosine triphosphatase (GTPase) activity of the…”
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Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells by Buerger, Claudia, Nagel-Wolfrum, Kerstin, Kunz, Christian, Wittig, Ilka, Butz, Karin, Hoppe-Seyler, Felix, Groner, Bernd

“…Receptor tyrosine kinases of the epidermal growth factor (EGF) receptor family regulate essential cellular functions such as proliferation, survival,…”
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Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro by Jahn, Magdalena, Lang, Victoria, Diehl, Sandra, Back, Robin, Kaufmann, Roland, Fauth, Torsten, Buerger, Claudia

“…Dermatological research relies on the availability of suitable models that most accurately reflect the in vivo situation. Primary keratinocytes obtained from…”
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IL-17E (IL-25) and IL-17A Differentially Affect the Functions of Human Keratinocytes by Borowczyk, Julia, Buerger, Claudia, Tadjrischi, Neschaat, Drukala, Justyna, Wolnicki, Michal, Wnuk, Dawid, Modarressi, Ali, Boehncke, Wolf-Henning, Brembilla, Nicolò Costantino

“…Our group has recently shown that keratinocyte-derived IL-17E (IL-25), one of six members of the IL-17 family, is overexpressed in lesional psoriatic skin and…”
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A Novel Epidermis Model Using Primary Hidradenitis Suppurativa Keratinocytes by Haferland, Isabel, Pinter, Andreas, Rossmanith, Tanja, Diehl, Sandra, Buerger, Claudia, Ickelsheimer, Tanja, Kaufmann, Roland, Koenig, Anke

“…Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Patients can present with inflammatory nodules, abscesses up to fistulas, or sinus tracts…”
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The Ca2+ channel TRPV4 is dispensable for Ca2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines by Ritzmann, Dirk, Jahn, Magdalena, Heck, Susanne, Jung, Cristina, Cesetti, Tiziana, Couturier, Nathalie, Rudolf, Rüdiger, Reuscher, Naemi, Buerger, Claudia, Rauh, Oliver, Fauth, Torsten

“…•Volume regulation upon hypotonic stress involves Ca2+ influx in keratinocytes.•Loss-of-function study to clarify role of TRPV4 as volume sensor in…”
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Mechanism of anti‐inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa by Haferland, Isabel, Wallenwein, Chantal M., Ickelsheimer, Tanja, Diehl, Sandra, Wacker, Matthias G., Schiffmann, Susanne, Buerger, Claudia, Kaufmann, Roland, Koenig, Anke, Pinter, Andreas

“…Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the hair follicles leading to painful lesions, associated with increased levels of…”
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Interleukin-1β Interferes with Epidermal Homeostasis through Induction of Insulin Resistance: Implications for Psoriasis Pathogenesis by Buerger, Claudia, Richter, Beatrice, Woth, Kathrin, Salgo, Rebekka, Malisiewicz, Bartosz, Diehl, Sandra, Hardt, Katja, Boehncke, Sandra, Boehncke, Wolf-Henning

“…Response pathways of the metabolic and the immune system have been evolutionary conserved, resulting in a high degree of integrated regulation. Insulin is a…”
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Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice by Bürger, Claudia, Shirsath, Nitesh, Lang, Victoria, Diehl, Sandra, Kaufmann, Roland, Weigert, Andreas, Han, Ying-Ying, Ringel, Christian, Wolf, Peter

“…The mTOR (mechanistic target of rapamycin) inhibitor rapamycin has long been known for its immune suppressive properties, but it has shown limited therapeutic…”
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PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells by Lee, Sophia Boyoung, Doberstein, Kai, Baumgarten, Peter, Wieland, Anja, Ungerer, Christopher, Bürger, Claudia, Hardt, Katja, Boehncke, Wolf-Henning, Pfeilschifter, Josef, Mihic-Probst, Daniela, Mittelbronn, Michel, Gutwein, Paul

“…PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and…”
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The Ca 2+ channel TRPV4 is dispensable for Ca 2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines by Ritzmann, Dirk, Jahn, Magdalena, Heck, Susanne, Jung, Cristina, Cesetti, Tiziana, Couturier, Nathalie, Rudolf, Rüdiger, Reuscher, Naemi, Buerger, Claudia, Rauh, Oliver, Fauth, Torsten

“…Cell swelling as a result of hypotonic stress is counteracted in mammalian cells by a process called regulatory volume decrease (RVD). We have recently…”
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