Search Results - "Bueler, Hansruedi"

Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain by Büeler, Hansruedi

“…Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the…”
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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease by Bueeler, Hansruedi

“…Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars…”
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A Model for Gene Therapy of Human Hereditary Lymphedema by Karkkainen, Marika J., Saaristo, Anne, Jussila, Lotta, Karila, Kaisa A., Lawrence, Elizabeth C., Pajusola, Katri, Bueler, Hansruedi, Eichmann, Anne, Kauppinen, Risto, Kettunen, Mikko I., Ylä-Herttuala, Seppo, Finegold, David N., Ferrell, Robert E., Alitalo, Kari

“…Primary human lymphedema (Milroy's disease), characterized by a chronic and disfiguring swelling of the extremities, is associated with heterozygous…”
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Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus by Agnihotri, Sandeep Kumar, Shen, Ruifang, Li, Jihong, Gao, Xu, Büeler, Hansruedi

“…ABSTRACT Emerging evidence suggests that mitochondrial dynamics regulates adult hippocampal neurogenesis (AHN). Although abnormal AHN has been linked to…”
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Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction by Sulg, Marilin, Kirjavainen, Anna, Pajusola, Katri, Bueler, Hansruedi, Ylikoski, Jukka, Laiho, Marikki, Pirvola, Ulla

“…J. Neurochem. (2010) 112, 1513-1526. Previous studies have shown that the maintenance of post-mitotic state is critical for the life-long survival of the inner…”
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Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death by Sun, Liuke, Shen, Ruifang, Agnihotri, Sandeep K., Chen, Yun, Huang, Zhiwei, Büeler, Hansruedi

“…Neuroinflammation is involved in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a…”
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Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1 by Sun, Liuke, Büeler, Hansruedi

“…Mutations of PTEN-induced kinase 1 (PINK1) cause recessive familial Parkinson's disease. Cells lacking PINK1 display mitochondrial deficits and increased…”
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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein by Büeler, Hansruedi, Fischer, Marek, Lang, Yolande, Bluethmann, Horst, Lipp, Hans-Peter, DeArmond, Stephen J, Prusiner, Stanley B, Aguet, Michel, Weissmann, Charles

“…PrPC is a host protein anchored to the outer surface of neurons and to a lesser extent of lymphocytes and other cells. The transmissible agent (prion)…”
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Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons by Wang, Ruishan, Li, Jing Jing, Diao, Shiyong, Kwak, Young-Don, Liu, Li, Zhi, Lianteng, Büeler, Hansruedi, Bhat, Narayan R., Williams, Robert W., Park, Edwards A., Liao, Francesca-Fang

“…Classic cardio-metabolic risk factors such as hypertension, stroke, diabetes, and hypercholesterolemia all increase the risk of Alzheimer’s disease. We found…”
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Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease by Triplett, Judy C., Zhang, Zhaoshu, Sultana, Rukhsana, Cai, Jian, Klein, Jon B., Büeler, Hansruedi, Butterfield, David Allan

“…Parkinson's disease (PD) is an age‐related, neurodegenerative motor disorder characterized by progressive degeneration of dopaminergic neurons in the…”
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PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice by Agnihotri, Sandeep K., Sun, Liuke, Yee, Benjamin K., Shen, Ruifang, Akundi, Ravi S., Zhi, Lianteng, Duncan, Marilyn J., Cass, Wayne A., Büeler, Hansruedi

“…•PINK1 loss and chronic stress jointly inhibit adult hippocampal neurogenesis (AHN).•AHN deficits per se do not cause abnormal affective behavior in PINK1−/−…”
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Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T‐cell development and function by Ellis, Gavin I., Zhi, Lianteng, Akundi, Ravi, Büeler, Hansruedi, Marti, Francesc

“…Mutations in PTEN‐induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early‐onset Parkinsonism, compromise mitochondrial integrity and…”
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Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice by Akundi, Ravi S, Huang, Zhenyu, Eason, Joshua, Pandya, Jignesh D, Zhi, Lianteng, Cass, Wayne A, Sullivan, Patrick G, Büeler, Hansruedi

“…PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial…”
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Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice by Sanchez, Gonzalo, Varaschin, Rafael K, Büeler, Hansruedi, Marcogliese, Paul C, Park, David S, Trudeau, Louis-Eric

“…Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the…”
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PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis by Akundi, Ravi S, Zhi, Lianteng, Büeler, Hansruedi

“…Abstract Mutations in the PARK6 gene coding for PTEN-induced kinase 1 (PINK1) cause recessive early-onset Parkinsonism. Although PINK1 and Parkin promote the…”
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Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission by Zhu, Dantong, Han, Fengtong, Sun, Liuke, Agnihotri, Sandeep K, Hu, Ying, Büeler, Hansruedi

“…Mitochondrial metabolism and dynamics (fission and fusion) critically regulate cell survival and proliferation, and abnormalities in these pathways are…”
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Transduction Profiles of Recombinant Adeno-Associated Virus Vectors Derived from Serotypes 2 and 5 in the Nigrostriatal System of Rats by Paterna, Jean-Charles, Feldon, Joram, Büeler, Hansruedi

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways by Saini, Nidhi, Oelhafen, Sandra, Hua, Haiqing, Georgiev, Oleg, Schaffner, Walter, Büeler, Hansruedi

“…Abstract The mechanisms underlying neuron death in Parkinson's disease are unknown, but both genetic defects and environmental factors are implicated in its…”
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Cell-Type-Specific Characteristics Modulate the Transduction Efficiency of Adeno-Associated Virus Type 2 and Restrain Infection of Endothelial Cells by Pajusola, Katri, Gruchala, Marcin, Joch, Hana, Lüscher, Thomas F, Ylä-Herttuala, Seppo, Büeler, Hansruedi

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dopamine-Dependent Neurodegeneration in Rats Induced by Viral Vector-Mediated Overexpression of the Parkin Target Protein, CDCrel-1 by Dong, Zhizhong, Ferger, Boris, Paterna, Jean-Charles, Vogel, Denise, Furler, Sven, Osinde, Maribel, Feldon, Joram, Büeler, Hansruedi

“…Mutations in the parkin gene are linked to autosomal-recessive juvenile parkinsonism (AR-JP). Parkin functions as a ubiquitin protein ligase in the degradation…”
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