Search Results - "Buehler, Christof"

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR by Seifert, Jan-Marcus, Bauer, Roman, Uhl, Volker, Auer, Manfred, Meisner, Nicole-Claudia, Ottl, Johannes, Harrer, Nathalie, Naegeli, Hans-Ulrich, Moss, Serge, Hintersteiner, Martin, Mueller, Kurt, Oberer, Lukas, Woisetschlaeger, Maximilian, Buehler, Christof, Guenat, Christian

“…Careful regulation of mRNA half-lives is a fundamental mechanism allowing cells to quickly respond to changing environmental conditions. The mRNA-binding Hu…”
Get full text

On-Bead Screens Sample Narrower Affinity Ranges of Protein-Ligand Interactions Compared to Equivalent Solution Assays by Hintersteiner, Martin, Buehler, Christof, Auer, Manfred

“…Conceptually, on‐bead screening is one of the most efficient high‐throughput screening (HTS) methods. One of its inherent advantages is that the solid support…”
Get full text

ICU Cockpit: a platform for collecting multimodal waveform data, AI-based computational disease modeling and real-time decision support in the intensive care unit by Boss, Jens Michael, Narula, Gagan, Straessle, Christian, Willms, Jan, Azzati, Jan, Brodbeck, Dominique, Luethy, Rahel, Suter, Susanne, Buehler, Christof, Muroi, Carl, Mack, David Jule, Seric, Marko, Baumann, Daniel, Keller, Emanuela

“…Abstract ICU Cockpit: a secure, fast, and scalable platform for collecting multimodal waveform data, online and historical data visualization, and online…”
Get full text

Multifocal multiphoton microscopy based on multianode photomultiplier tubes by Kim, Ki Hean, Buehler, Christof, Bahlmann, Karsten, Ragan, Timothy, Lee, Wei-Chung A, Nedivi, Elly, Heffer, Erica L, Fantini, Sergio, So, Peter T C

“…Multifocal multiphoton microscopy (MMM) enhances imaging speed by parallelization. It is not well understood why the imaging depth of MMM is significantly…”
Get full text

Novel 1:1 Labeling and Purification Process for C‑Terminal Thioester and Single Cysteine Recombinant Proteins Using Generic Peptidic Toolbox Reagents by Portal, Christophe F, Seifert, Jan-Marcus, Buehler, Christof, Meisner-Kober, Nicole-Claudia, Auer, Manfred

“…We developed a versatile set of chemical labeling reagents which allow dye ligation to the C-terminus of a protein or a single internal cysteine and target…”
Get full text

Covalent Fluorescence Labeling of His-Tagged Proteins on the Surface of Living Cells by Hintersteiner, Martin, Weidemann, Thomas, Kimmerlin, Thierry, Filiz, Nimet, Buehler, Christof, Auer, Manfred

“…Labeling His‐tagged proteins on living cells. NTA‐based covalent labeling reagents for His‐tagged proteins were designed by combining the oligo‐His directing…”
Get full text

Mitigating thermal mechanical damage potential during two-photon dermal imaging by Masters, Barry R, So, Peter T C, Buehler, Christof, Barry, Nicholas, Sutin, Jason D, Mantulin, William W, Gratton, Enrico

“…Two-photon excitation fluorescence microscopy allows in vivo high-resolution imaging of human skin structure and biochemistry with a penetration depth over 100…”
Get more information

Single-photon counting multicolor multiphoton fluorescence microscope by Buehler, Christof, Kim, Ki H, Greuter, Urs, Schlumpf, Nick, So, Peter T C

“…We present a multicolor multiphoton fluorescence microscope with single-photon counting sensitivity. The system integrates a standard multiphoton fluorescence…”
Get full text

Multi-photon excitation of intrinsic protein fluorescence and its application to pharmaceutical drug screening by Buehler, Christof, Dreessen, Joerg, Mueller, Kurt, So, Peter T C, Schilb, Alain, Hassiepen, Ulrich, Stoeckli, Kurt A, Auer, Manfred

“…The majority of proteins contain intrinsic fluorophores as natural sensors of molecular structures, dynamics, and interactions. The intrinsic protein…”
Get more information

Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo by Masters, B R, So, P T, Kim, K H, Buehler, C, Gratton, E

Get more information

Two-photon tissue optical biopsy by So, Peter, Ki, Kim H, Hsu, Lily, Dong, Chen Y, Christof, Buehler

“…Two-photon microscopy is a powerful technique that allows three dimensional imaging of tissue structures with sub-micron resoltion. This article provides a…”
Get full text

Single Bead Labeling Method for Combining Confocal Fluorescence On-Bead Screening and Solution Validation of Tagged One-Bead One-Compound Libraries by Hintersteiner, Martin, Kimmerlin, Thierry, Kalthoff, Frank, Stoeckli, Markus, Garavel, Geraldine, Seifert, Jan-Marcus, Meisner, Nicole-Claudia, Uhl, Volker, Buehler, Christof, Weidemann, Thomas, Auer, Manfred

“…Screening of one-bead one-compound libraries by incubating beads with fluorescently labeled target protein requires isolation and structure elucidation of a…”
Get full text

Confocal Nanoscanning, Bead Picking (CONA): PickoScreen Microscopes for Automated and Quantitative Screening of One-Bead One-Compound Libraries by Hintersteiner, Martin, Buehler, Christof, Uhl, Volker, Schmied, Mario, Müller, Jürgen, Kottig, Karsten, Auer, Manfred

“…Solid phase combinatorial chemistry provides fast and cost-effective access to large bead based libraries with compound numbers easily exceeding tens of…”
Get full text

Innovations in two-photon deep tissue microscopy by Buehler, C., Ki Hean Kim, Dong, C.Y., Masters, B.R., So, P.T.C.

“…The goal of this article is to provide a review of deep tissue studies based on two-photon microscopy. We will further explore three new developments that have…”
Get full text