PCR diagnosis of sequences of a novel human herpes virus type 8 in patients with Kaposi sarcoma in Russia

Associations of a new human herpesvirus type 8 (HHV-8) with different forms of Kaposi's sarcoma (KS) in Russia have been studied. Search for this virus genetic information has been carried out in biopsy specimens of benign and malignant tumors other than KS, and probable sites of HHV-8 latency...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 45; no. 4; p. 13
Main Authors:	Galetskiĭ, S A, Kadyrova, E L, Kozyrev, Iu L, Molochkov, A V, Seniuta, N B, Shakhgil'dian, V I, Kravchenko, A V, Budoragin, E S, Chistiakova, I A, Lezvinskaia, E M, Kazantseva, I A, Samsonov, V A, Molochkov, V A, Gurtsevich, V E
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-2000
Subjects:	Blotting, Southern DNA, Viral - genetics Female Herpesvirus 8, Human - genetics Humans Male Polymerase Chain Reaction Sarcoma, Kaposi - genetics Sarcoma, Kaposi - virology
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Summary:	Associations of a new human herpesvirus type 8 (HHV-8) with different forms of Kaposi's sarcoma (KS) in Russia have been studied. Search for this virus genetic information has been carried out in biopsy specimens of benign and malignant tumors other than KS, and probable sites of HHV-8 latency in human body have been checked. HHV-8 sequences were detected by polymerase chain reaction (PCR). HHV-8 sequences were most often detected in idiopathic (80.6%), AIDS-associated (80%), and immunosuppressive (100%) KS. The results indicate a selective association of HHV-8 with KS. No probable sites of the virus latency were detected in peripheral blood cells of patients with KS and in the prostate of patients with chronic prostatitis. The only exception was the husband of a patient with KS: HHV-8 sequences were detected in his prostatic secretion by nested PCR.
ISSN:	0507-4088