Search Results - "Budinger, Scott"

The role of macrophages in the resolution of inflammation by Watanabe, Satoshi, Alexander, Michael, Misharin, Alexander V, Budinger, G R Scott

“…Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue…”
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Influenza virus-induced lung injury: pathogenesis and implications for treatment by Herold, Susanne, Becker, Christin, Ridge, Karen M, Budinger, G R Scott

“…The influenza viruses are some of the most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. In humans, infection…”
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Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung by Misharin, Alexander V, Morales-Nebreda, Luisa, Mutlu, Gökhan M, Budinger, G R Scott, Perlman, Harris

“…The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial role in lung pathology. The accurate identification and…”
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Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage by Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Morales-Nebreda, Luisa, Cheng, Yuan, Hogan, Erin, Yeldandi, Anjana, Chi, Monica, Piseaux, Raul, Ridge, Karen, Michael Hart, C., Chandel, Navdeep, Scott Budinger, G.R., Kamp, David W.

“…Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos…”
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Role of Hypoxia-Inducible Factors in Regulating Right Ventricular Function and Remodeling during Chronic Hypoxia-induced Pulmonary Hypertension by Smith, Kimberly A, Waypa, Gregory B, Dudley, V Joseph, Budinger, G R Scott, Abdala-Valencia, Hiam, Bartom, Elizabeth, Schumacker, Paul T

“…Pulmonary hypertension (PH) and right ventricular (RV) hypertrophy frequently develop in patients with hypoxic lung disease. Chronic alveolar hypoxia (CH)…”
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A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages by Joshi, Nikita, Watanabe, Satoshi, Verma, Rohan, Jablonski, Renea P, Chen, Ching-I, Cheresh, Paul, Markov, Nikolay S, Reyfman, Paul A, McQuattie-Pimentel, Alexandra C, Sichizya, Lango, Lu, Ziyan, Piseaux-Aillon, Raul, Kirchenbuechler, David, Flozak, Annette S, Gottardi, Cara J, Cuda, Carla M, Perlman, Harris, Jain, Manu, Kamp, David W, Budinger, G R Scott, Misharin, Alexander V

“…Ontologically distinct populations of macrophages differentially contribute to organ fibrosis through unknown mechanisms.We applied lineage tracing,…”
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Lung transplantation for patients with severe COVID-19 by Bharat, Ankit, Querrey, Melissa, Markov, Nikolay S, Kim, Samuel, Kurihara, Chitaru, Garza-Castillon, Rafael, Manerikar, Adwaiy, Shilatifard, Ali, Tomic, Rade, Politanska, Yuliya, Abdala-Valencia, Hiam, Yeldandi, Anjana V, Lomasney, Jon W, Misharin, Alexander V, Budinger, G R Scott

“…Lung transplantation can potentially be a life-saving treatment for patients with nonresolving COVID-19-associated respiratory failure. Concerns limiting lung…”
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The heterogeneity of lung macrophages in the susceptibility to disease by Morales-Nebreda, Luisa, Misharin, Alexander V, Perlman, Harris, Budinger, G R Scott

“…Alveolar macrophages are specialised resident phagocytes in the alveolus, constituting the first line of immune cellular defence in the lung. As the lung…”
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Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice by Misharin, Alexander V., Cuda, Carla M., Saber, Rana, Turner, Jason D., Gierut, Angelica K., Haines, G. Kenneth, Berdnikovs, Sergejs, Filer, Andrew, Clark, Andrew R., Buckley, Christopher D., Mutlu, Gökhan M., Budinger, G.R. Scott, Perlman, Harris

“…Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here,…”
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SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis by Jablonski, Renea P., Kim, Seok‐Jo, Cheresh, Paul, Williams, David B., Morales‐Nebreda, Luisa, Cheng, Yuan, Yeldandi, Anjana, Bhorade, Sangeeta, Pardo, Annie, Selman, Moises, Ridge, Karen, Gius, David, Scott Budinger, G. R., Kamp, David W.

“…ABSTRACT Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pulmonary fibrosis and asbestosis. Sirtuin 3…”
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Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung by Duch, Matthew C, Budinger, G. R. Scott, Liang, Yu Teng, Soberanes, Saul, Urich, Daniela, Chiarella, Sergio E, Campochiaro, Laura A, Gonzalez, Angel, Chandel, Navdeep S, Hersam, Mark C, Mutlu, Gökhan M

“…To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the…”
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity by Weinberg, Frank, Hamanaka, Robert, Wheaton, William W, Weinberg, Samuel, Joseph, Joy, Lopez, Marcos, Kalyanaraman, Balaraman, Mutlu, Gökhan M, Budinger, G.R. Scott, Chandel, Navdeep S

“…Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative phosphorylation and therefore rely on high…”
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Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19 by Gao, Catherine A, Markov, Nikolay S, Stoeger, Thomas, Pawlowski, Anna, Kang, Mengjia, Nannapaneni, Prasanth, Grant, Rogan A, Pickens, Chiagozie, Walter, James M, Kruser, Jacqueline M, Rasmussen, Luke, Schneider, Daniel, Starren, Justin, Donnelly, Helen K, Donayre, Alvaro, Luo, Yuan, Budinger, G R Scott, Wunderink, Richard G, Misharin, Alexander V, Singer, Benjamin D

“…BACKGROUNDDespite guidelines promoting the prevention and aggressive treatment of ventilator-associated pneumonia (VAP), the importance of VAP as a driver of…”
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Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts by Cerier, Emily, Kurihara, Chitaru, Kaiho, Taisuke, Toyoda, Takahide, Manerikar, Adwaiy, Kandula, Viswajit, Thomae, Benjamin, Yagi, Yuriko, Yeldandi, Anjana, Kim, Samuel, Avella-Patino, Diego, Pandolfino, John, Perlman, Harris, Singer, Benjamin, Scott Budinger, G.R., Lung, Kalvin, Alexiev, Borislav, Bharat, Ankit

“…Growing evidence implicates complement in the pathogenesis of primary graft dysfunction (PGD). We hypothesized that early complement activation postreperfusion…”
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Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling by Shigemura, Masahiko, Lecuona, Emilia, Angulo, Martín, Homma, Tetsuya, Rodríguez, Diego A, Gonzalez-Gonzalez, Francisco J, Welch, Lynn C, Amarelle, Luciano, Kim, Seok-Jo, Kaminski, Naftali, Budinger, G R Scott, Solway, Julian, Sznajder, Jacob I

“…The elevation of carbon dioxide (CO ) in tissues and the bloodstream (hypercapnia) occurs in patients with severe lung diseases, including chronic obstructive…”
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Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice by Coates, Bria M, Staricha, Kelly L, Koch, Clarissa M, Cheng, Yuan, Shumaker, Dale K, Budinger, G R Scott, Perlman, Harris, Misharin, Alexander V, Ridge, Karen M

“…Healthy children are more likely to die of influenza A virus (IAV) infection than healthy adults. However, little is known about the mechanisms underlying the…”
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Alveolar epithelial regeneration in the aging lung by Han, SeungHye, Budinger, G R Scott, Gottardi, Cara J

“…Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic…”
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Donor-Derived Ureaplasma is a Potentially Lethal Infection in Lung Allograft Recipients by Bharat, Ankit, Budinger, G.R. Scott, Ison, Michael G

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Tenascin-C drives persistence of organ fibrosis by Bhattacharyya, Swati, Wang, Wenxia, Morales-Nebreda, Luisa, Feng, Gang, Wu, Minghua, Zhou, Xiaodong, Lafyatis, Robert, Lee, Jungwha, Hinchcliff, Monique, Feghali-Bostwick, Carol, Lakota, Katja, Budinger, G. R. Scott, Raparia, Kirtee, Tamaki, Zenshiro, Varga, John

“…The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like…”
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SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment by Cheresh, Paul, Kim, Seok-Jo, Jablonski, Renea, Watanabe, Satoshi, Lu, Ziyan, Chi, Monica, Helmin, Kathryn A, Gius, David, Budinger, G R Scott, Kamp, David W

“…Alveolar epithelial cell (AEC) mitochondrial (mt) DNA damage and fibrotic monocyte-derived alveolar macrophages (Mo-AMs) are implicated in the pathobiology of…”
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