The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes

The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes

We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a single shot of Co 60 at a dose of 2 Gy on the 7-month-old male mice of the ICR line in 30 days after the irradiation. The aim of this study was to characterize the behavior of animal...

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Bibliographic Details
Published in:Cellular and molecular neurobiology Vol. 43; no. 7; pp. 3723 - 3741
Main Authors: Kolesnikova, I. A., Lalkovičova, M., Severyukhin, Yu. S., Golikova, K. N., Utina, D. M., Pronskikh, E. V., Despotović, Sanja Z., Gaevsky, V. N., Pirić, D., Masnikosa, R., Budennaya, N. N.
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2023
Springer Nature B.V
Subjects:
Age
Behavior
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central nervous system
Gamma rays
Hematology
Ionizing radiation
Leukocytes
Neurobiology
Neurosciences
Open-field behavior
Original Research
Peripheral blood
Radiation
γ Radiation
Gamma irradiation
Patho-morphology
Behavior
Neurodegeneration
Long-term effects
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Summary:We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a single shot of Co 60 at a dose of 2 Gy on the 7-month-old male mice of the ICR line in 30 days after the irradiation. The aim of this study was to characterize the behavior of animals using the Open Field test, immuno-hematological status, and morpho-functional changes in the central nervous system of mice. Irradiated animals displayed significantly different behavior in the OF in comparison with the control group. The radiation damage was confirmed by assessing the ratio of leukocytes in the peripheral blood of mice at a later date after exposure to Co 60 . After irradiation, a decrease in the glioneuronal complex was observed in the irritated group as well as histological changes of brain cells. To sum up, not only was the hematological status of mice altered upon the total gamma irradiation, but also their behavior, which was most probably due to significant alterations in the CNS. Graphical Abstract Study of influence of ionizing radiation on female mice, comparison between different age groups. Open Field test on the 30 days after 2 Gy of γ-rays and histological analysis indicated changes in behavioral patterns, leucocytes, and brain tissue.
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ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-023-01381-1