Search Results - "Buddington, Randal"

Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake by Buddington, Randal K, Kapadia, Cavita, Neumer, Franka, Theis, Stephan

“…Inadequate dietary fiber intake contributes to the prevalent irregularity and constipation in Western countries. Although eating adequate amounts of fibers…”
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Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia by Iskusnykh, Igor Y., Buddington, Randal K., Chizhikov, Victor V.

“…Preterm birth is a leading cause of long-term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of…”
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Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC/Pard3a molecular pathway by Iskusnykh, Igor Y., Fattakhov, Nikolai, Buddington, Randal K., Chizhikov, Victor V.

“…Intrauterine growth restriction (IUGR) affects ~10% of human pregnancies, results in infants born small for gestational age (SGA), and is associated with motor…”
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Allergic Reactions to E. coli Asparaginase are Associated with Decreased Asparaginase Activity in an Indonesian Pediatric Population with ALL by Sari, Nur Melani, Berbudi, Afiat, Susanah, Susi, Reniarti, Lelani, Supriyadi, Eddy, Kaspers, Gertjan J L, Buddington, Randal K, Howard, Scott, Idjradinata, Ponpon

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A preterm pig model of lung immaturity and spontaneous infant respiratory distress syndrome by Caminita, Frank, van der Merwe, Marie, Hance, Brittany, Krishnan, Ramesh, Miller, Sarah, Buddington, Karyl, Buddington, Randal K

“…Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia remain the leading causes of preterm infant morbidity, mortality, and lifelong disability…”
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K V 7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure by Peixoto-Neves, Dieniffer, Kanthakumar, Praghalathan, Afolabi, Jeremiah M, Soni, Hitesh, Buddington, Randal K, Adebiyi, Adebowale

“…K 7 channels, the voltage-gated K channels encoded by KCNQ genes, mediate heterogeneous vascular responses in rodents. Postnatal changes in the functional…”
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Preterm birth disrupts the development of feeding and breathing coordination by Mayerl, Christopher J, Gould, Francois D H, Bond, Laura E, Stricklen, Bethany M, Buddington, Randal K, German, Rebecca Z

“…All mammals must breathe and breathe continuously from birth. Similarly, all mammals, including infants, have high functional demands for feeding. However, the…”
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Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice by Wong, Thomas, Bloomer, Richard J, Benjamin, Rodney L, Buddington, Randal K

“…The principal dietary sources of sulfur, the amino acids methionine and cysteine, may not always be consumed in adequate amounts to meet sulfur requirements…”
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The Risk of Necrotizing Enterocolitis Differs Among Preterm Pigs Fed Formulas With Either Lactose or Maltodextrin by Buddington, Randal K., Davis, Samantha L., Buddington, Karyl K.

“…ABSTRACT Objectives: When breast milk is unavailable for preterm infants, formulas are needed that won't increase the risk of necrotizing enterocolitis (NEC)…”
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Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species by Matthews, Anberitha T., Soni, Hitesh, Robinson-Freeman, Katherine E., John, Theresa A., Buddington, Randal K., Adebiyi, Adebowale

“…Doxorubicin (DOX), a category D pregnancy drug, is a chemotherapeutic agent that has been shown in animal studies to induce fetal toxicity, including renal…”
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Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing by Ibarra, Manuel, Combs, Ryan, Taylor, Zachary L., Ramsey, Laura B., Mikkelsen, Torben, Buddington, Randal K., Heldrup, Jesper, Barreto, Jason N., Guscott, Martin, Lowe, Jennifer, Hurmiz, Charles, Marada, Suresh, Howard, Scott C., Schaiquevich, Paula

“…Aims High‐dose methotrexate (HDMTX) is an essential part of the treatment of several adult and paediatric malignancies. Despite meticulous supportive care…”
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Adenosine A 1 receptor-operated calcium entry in renal afferent arterioles is dependent on postnatal maturation of TRPC3 channels by Soni, Hitesh, Peixoto-Neves, Dieniffer, Buddington, Randal K, Adebiyi, Adebowale

“…Adenosine, a regulator of cardiovascular development and renal function, constricts renal afferent arterioles by inducing intracellular Ca concentration ([Ca ]…”
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Nutrient Intake and Physical Exercise Significantly Impact Physical Performance, Body Composition, Blood Lipids, Oxidative Stress, and Inflammation in Male Rats by Bloomer, Richard J, Schriefer, John Henry M, Gunnels, Trint A, Lee, Sang-Rok, Sable, Helen J, van der Merwe, Marie, Buddington, Randal K, Buddington, Karyl K

“…Humans consuming a purified vegan diet known as the "Daniel Fast" realize favorable changes in blood lipids, oxidative stress, and inflammatory biomarkers,…”
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A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs by Buddington, Randal K, Chizhikov, Victor V, Iskusnykh, Igor Y, Sable, Helen J, Sable, Jeffrey J, Holloway, Zade R, Blumenfeld Katzir, Tamar, van der Merwe, Marie, Yakimkova, Taisiya, Buddington, Karyl K, Lifshitz, Yael, Tessler, Shoshi, Gilbert, Ariel

“…The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for…”
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Selective and Concentrative Enteropancreatic Recirculation of Antibiotics by Pigs by Buddington, Karyl K, Pierzynowski, Stefan G, Holmes, William E, Buddington, Randal K

“…Antibiotics that are efficacious for infectious pancreatitis are present in pancreatic exocrine secretion (PES) after intravenous administration and above…”
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Multiple Asparaginase Infusions Cause Increasingly Severe Acute Hyperammonemia by Buddington, Randal K, Buddington, Karyl K, Howard, Scott C

“…Adverse reactions during and shortly after infusing asparaginase for the treatment of acute lymphoblastic leukemia can increase in severity with later doses,…”
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Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea by Moon, Changsuk, Zhang, Weiqiang, Ren, Aixia, Arora, Kavisha, Sinha, Chandrima, Yarlagadda, Sunitha, Woodrooffe, Koryse, Schuetz, John D., Valasani, Koteswara Rao, de Jonge, Hugo R., Shanmukhappa, Shiva Kumar, Shata, Mohamed Tarek M., Buddington, Randal K., Parthasarathi, Kaushik, Naren, Anjaparavanda P.

“…Diarrhea is one of the most common adverse side effects observed in ∼7% of individuals consuming Food and Drug Administration (FDA)-approved drugs. The…”
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Effects of Phosphatidylserine Source of Docosahexaenoic Acid on Cerebellar Development in Preterm Pigs by Chizhikov, Daniel, Buddington, Randal K, Iskusnykh, Igor Y

“…Preterm birth, a major contributor to infant mortality and morbidity, impairs development of the cerebellum, the brain region involved in cognitive processing…”
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Growth Responses of Preterm Pigs Fed Formulas with Different Protein Levels and Supplemented with Leucine or β-Hydroxyl β-Methylbutyrate by Buddington, Randal K, Howard, Scott C, Lee, Harold W, Buddington, Karyl K

“…Growth after preterm birth is an important determinant of long-term outcomes. Yet, many preterm infants suffer ex utero growth retardation. We evaluated…”
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Paracellular Filtration Secretion Driven by Mechanical Force Contributes to Small Intestinal Fluid Dynamics by Buddington, Randal K, Wong, Thomas, Howard, Scott C

“…Studies of fluid secretion by the small intestine are dominated by the coupling with ATP-dependent generation of ion gradients, whereas the contribution of…”
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