Search Results - "Buddika, Kasun"

The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance by Ariyapala, Ishara S, Buddika, Kasun, Hundley, Heather A, Calvi, Brian R, Sokol, Nicholas S

“…Abstract The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the…”
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Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye by Zhu, Jinjin, Ordway, Alison J, Weber, Lena, Buddika, Kasun, Kumar, Justin P

“…How different cells and tissues commit to and determine their fates has been a central question in developmental biology since the seminal embryological…”
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Canonical nucleators are dispensable for stress granule assembly in Drosophila intestinal progenitors by Buddika, Kasun, Ariyapala, Ishara S, Hazuga, Mary A, Riffert, Derek, Sokol, Nicholas S

“…Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Although SGs have been extensively…”
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Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity by Buddika, Kasun, Huang, Yi-Ting, Ariyapala, Ishara S., Butrum-Griffith, Alex, Norrell, Sam A., O’Connor, Alex M., Patel, Viraj K., Rector, Samuel A., Slovan, Mark, Sokolowski, Mallory, Kato, Yasuko, Nakamura, Akira, Sokol, Nicholas S.

“…The role of processing bodies (P-bodies), key sites of post-transcriptional control, in adult stem cells remains poorly understood. Here, we report that adult…”
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Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth by Luhur, Arthur, Buddika, Kasun, Ariyapala, Ishara Surangi, Chen, Shengyao, Sokol, Nicholas Samuel

“…Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain…”
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NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing by Feng, Wei, Beer, Joanne C., Hao, Qinyu, Ariyapala, Ishara S., Sahajan, Aparna, Komarov, Andrei, Cha, Katie, Moua, Mason, Qiu, Xiaolei, Xu, Xiaomei, Iyengar, Shweta, Yoshimura, Thu, Nagaraj, Rajini, Wang, Li, Yu, Ming, Engel, Kate, Zhen, Lucas, Xue, Wen, Lee, Chen-jung, Park, Chan Ho, Peng, Cheng, Zhang, Kaiyuan, Grzybowski, Adrian, Hahm, Johnnie, Schmidt, Susanne V., Odainic, Alexandru, Spitzer, Jasper, Buddika, Kasun, Kuo, Dwight, Fang, Lei, Zhang, Bingqing, Chen, Steve, Latz, Eicke, Yin, Yiyuan, Luo, Yuling, Ma, Xiao-Jun

“…The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast…”
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Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development by Li, Hongde, Rai, Madhulika, Buddika, Kasun, Sterrett, Maria C, Luhur, Arthur, Mahmoudzadeh, Nader H, Julick, Cole R, Pletcher, Rose C, Chawla, Geetanjali, Gosney, Chelsea J, Burton, Anna K, Karty, Jonathan A, Montooth, Kristi L, Sokol, Nicholas S, Tennessen, Jason M

“…The dramatic growth that occurs during larval development requires rapid conversion of nutrients into biomass. Many larval tissues respond to these…”
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Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions by Luhur, Arthur, Mariyappa, Daniel, Klueg, Kristin M, Buddika, Kasun, Tennessen, Jason M, Zelhof, Andrew C

“…Successful cell culture relies on media containing xenogenic components such as fetal bovine serum to support continuous cell proliferation. Here, we report a…”
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Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster by Mahmoudzadeh, Nader H., Heidarian, Yasaman, Tourigny, Jason P., Fitt, Alexander J., Beebe, Katherine, Li, Hongde, Luhur, Arthur, Buddika, Kasun, Mungcal, Liam, Kundu, Anirban, Policastro, Robert A., Brinkley, Garrett J., Zentner, Gabriel E., Nemkov, Travis, Pepin, Robert, Chawla, Geetanjali, Sudarshan, Sunil, Rodan, Aylin R., D'Alessandro, Angelo, Tennessen, Jason M.

“…The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite…”
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Identification and Characterization of Breakpoints and Mutations on Drosophila melanogaster Balancer Chromosomes by Miller, Danny E, Kahsai, Lily, Buddika, Kasun, Dixon, Michael J, Kim, Bernard Y, Calvi, Brian R, Sokol, Nicholas S, Hawley, R Scott, Cook, Kevin R

“…Abstract Balancers are rearranged chromosomes used in Drosophila melanogaster to maintain deleterious mutations in stable populations, preserve sets of linked…”
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I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells by Buddika, Kasun, Xu, Jingjing, Ariyapala, Ishara S, Sokol, Nicholas S

“…The adult intestinal epithelium is a model system for stem cell biology, but its utility is limited by current biochemical methods that lack cell type…”
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The Identity and Function of Cytoplasmic Messenger Ribonucleoprotein Complexes in Intestinal Progenitors of Adult Drosophila by Jayawardhana Koomangodage, Kasun Buddika

“…Tissue resident stem cells allow certain mature organs to expand or shrink depending on environmental triggers. These dynamic tissue behaviors are driven by…”
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I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells by Buddika, Kasun, Xu, Jingjing, Ariyapala, Ishara S, Sokol, Nicholas S

“…The adult Drosophila intestinal epithelium is a model system for stem cell biology, but its utility is limited by current biochemical methods that lack cell…”
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Canonical nucleators are dispensable for stress granule assembly in intestinal progenitors by Buddika, Kasun, Ariyapala, Ishara S, Hazuga, Mary A, Riffert, Derek, Sokol, Nicholas S

“…Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Extensively characterized in cultured cells,…”
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