Search Results - "Budde, Heike"

Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis by Jaeger, Timo, Budde, Heike, Flohé, Leopold, Menge, Ulrich, Singh, Mahavir, Trujillo, Madia, Radi, Rafael

“…Drug resistance and virulence of Mycobacterium tuberculosis are in part related to the pathogen’s antioxidant defense systems. KatG − strains are resistant to…”
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Trypanosoma brucei and Trypanosoma cruzi Tryparedoxin Peroxidases Catalytically Detoxify Peroxynitrite via Oxidation of Fast Reacting Thiols by Trujillo, Madia, Budde, Heike, Piñeyro, María Dolores, Stehr, Matthias, Robello, Carlos, Flohé, Leopold, Radi, Rafael

“…Macrophage activation is one of the hallmarks observed in trypanosomiasis, and the parasites must cope with the resulting oxidative burden, which includes the…”
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Peroxiredoxins in antioxidant defense and redox regulation by Flohé, Leopold, Budde, Heike, Hofmann, Birgit

“…Peroxiredoxins constitute a family of peroxidases that lack prosthetic groups or catalytically active heteroatoms. Instead, their peroxidatic activity is due…”
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Paleocene origin of a streamlined digestive symbiosis in leaf beetles by García-Lozano, Marleny, Henzler, Christine, Porras, Miguel Ángel González, Pons, Inès, Berasategui, Aileen, Lanz, Christa, Budde, Heike, Oguchi, Kohei, Matsuura, Yu, Pauchet, Yannick, Goffredi, Shana, Fukatsu, Takema, Windsor, Donald, Salem, Hassan

“…Timing the acquisition of a beneficial microbe relative to the evolutionary history of its host can shed light on the adaptive impact of a partnership. Here,…”
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Synthesis of phosphatidylcholine with defined fatty acid in the sn-1 position by lipase-catalyzed esterification and transesterification reaction by Adlercreutz, Dietlind, Budde, Heike, Wehtje, Ernst

“…The incorporation of caproic acid in the sn‐1 position of phosphatidylcholine (PC) catalyzed by lipase from Rhizopus oryzae was investigated in a water…”
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Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion by Castro, Helena, Sousa, Carla, Novais, Marta, Santos, Marta, Budde, Heike, Cordeiro-da-Silva, Anabela, Flohé, Leopold, Tomás, Ana M.

“…Tryparedoxins are components of the hydroperoxide detoxification cascades of Kinetoplastida, where they mediate electron transfer between trypanothione and a…”
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Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei brucei by Budde, Heike, Flohé, Leopold, Hecht, Hans-Jürgen, Hofmann, Birgit, Stehr, Matthias, Wissing, Josef, Lünsdorf, Heinrich

“…Tryparedoxin peroxidases (TXNPx) are peroxiredoxin-type enzymes that detoxify hydroperoxides in trypanosomatids. Reduction equivalents are provided by…”
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Tryparedoxin Peroxidase of Leishmania donovani: Molecular Cloning, Heterologous Expression, Specificity, and Catalytic Mechanism by Flohé, Leopold, Budde, Heike, Bruns, Karsten, Castro, Helena, Clos, Joachim, Hofmann, Birgit, Kansal-Kalavar, Sonia, Krumme, Dirk, Menge, Ulrich, Plank-Schumacher, Karin, Sztajer, Helena, Wissing, Joseph, Wylegalla, Claudia, Hecht, Hans-Jürgen

“…Tryparedoxin peroxidase (TXNPx) of Trypanosomatidae is the terminal peroxidase of a complex redox cascade that detoxifies hydroperoxides by NADPH (Nogoceke et…”
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Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantum by Castro, Helena, Budde, Heike, Flohé, Leopold, Hofmann, Birgit, Lünsdorf, Heinrich, Wissing, Joseph, Toms, Ana M

“…In Kinetoplastida, comprising the medically important parasites Trypanosoma brucei, T. cruzi, and Leishmania species, 2-Cys peroxiredoxins described to date…”
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Enzymes of the thiol-dependent hydroperoxide metabolism in pathogens as potential drug targets by Budde, Heike, Flohé, Leopold

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Verification of the interaction of a tryparedoxin peroxidase with tryparedoxin by ESI-MS/MS by Budde, Heike, Flohé, Leopold, Hofmann, Birgit, Nimtz, Manfred

“…Tryparedoxin peroxidases (TXNPx) catalyze hydroperoxide reduction by tryparedoxin (TXN) by an enzyme substitution mechanism presumed to involve three catalytic…”
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NMR Studies of the Interaction of Tryparedoxin with Redox-Inactive Substrate Homologues by Krumme, Dirk, Budde, Heike, Hecht, Hans-Jürgen, Menge, Ulrich, Ohlenschläger, Oliver, Ross, Anton, Wissing, Josef, Wray, Victor, Flohé, Leopold

“…Tryparedoxins (TXNs) are trypanothione-dependent peroxiredoxin oxidoreductases involved in hydroperoxide detoxification that have been shown to determine…”
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Structures of tryparedoxins revealing interaction with trypanothione by Hofmann, B, Budde, H, Bruns, K, Guerrero, S A, Kalisz, H M, Menge, U, Montemartini, M, Nogoceke, E, Steinert, P, Wissing, J B, Flohé, L, Hecht, H J

“…Tryparedoxins (TXNs) catalyse the reduction of peroxiredoxin-type peroxidases by the bis-glutathionyl derivative of spermidine, trypanothione, and are relevant…”
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Tryparedoxin Peroxidase of Leishmania donovani: Molecular Cloning, Heterologous Expression, Specificity, and Catalytic Mechanism: Volume 397, Number 2 (January 15, 2002), pages 324–335 by Flohé, Leopold, Budde, Heike, Bruns, Karsten, Castro, Helena, Clos, Joachim, Hofmann, Birgit, Kansal-Kalavar, Sonia, Krumme, Dirk, Menge, Ulrich, Plank-Schumacher, Karin, Sztajer, Helena, Wissing, Joseph, Wylegalla, Claudia, Hecht, Hans-Jürgen

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Tryparedoxin Peroxidase of Leishmania donovani: Molecular Cloning, Heterologous Expression, Specificity, and Catalytic Mechanism by Flohé, Leopold, Budde, Heike, Bruns, Karsten, Castro, Helena, Clos, Joachim, Hofmann, Birgit, Kansal-Kalavar, Sonia, Krumme, Dirk, Menge, Ulrich, Plank-Schumacher, Karin, Sztajer, Helena, Wissing, Joseph, Wylegalla, Claudia, Hecht, Hans-Jürgen

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